Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200437612> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4200437612 endingPage "5640" @default.
- W4200437612 startingPage "5627" @default.
- W4200437612 abstract "This study investigated the differential mechanisms of Rehmanniae Radix and Rehmanniae Radix Praeparata in improving diabetes in mice through AMPK-mediated NF-κB/NLRP3 signaling pathway. The diabetic mouse model was established with high-fat diet coupled with streptozotocin(STZ, intraperitoneal injection, 100 mg·kg~(-1), once a day for three consecutive days), after which the mice were randomly divided into model group, low-dose(5 g·kg~(-1)) and high-dose(15 g·kg~(-1)) Rehmanniae Radix groups, low-dose(5 g·kg~(-1)) and high-dose(15 g·kg~(-1)) Rehmanniae Radix Praeparata groups, catalpol group(250 mg·kg~(-1)), 5-hydroxymethylfurfural(5-HMF) group(250 mg·kg~(-1)), metformin group(250 mg·kg~(-1)), with the normal group also set. The organ indexes of heart,liver, spleen, lung, kidney and pancreas were calculated after four weeks of administration. The pathological changes and fibrosis of pancreas, kidney and liver in mice were observed by hematoxylin-eosin(HE) staining and Masson staining. Western blot was used to determine the expression levels of Toll-like receptor-4(TLR4), nuclear factor-κB(NF-κB), Nod-like receptor protein 3(NLRP3),interleukin-1β(IL-1β), adenosine monophosphate-activated protein kinase(AMPK), phosphorylated AMPK(p-AMPK) in the pancreas, kidney and liver of mice. Compared with the model group, the administration groups witnessed significant decrease in the liver,spleen, kidney, pancreas and fat indexes of diabetic mice, and there was no significant difference in heart and lung indexes. The pathological states and fibrosis of pancreatic, kidney and liver tissues were significantly improved after administration. Additionally, the expression levels of TLR4, NF-κB and NLRP3 in pancreas, kidney and liver of diabetic mice were significantly lowered. The expression levels of p-AMPK/AMPK were enhanced significantly in kidney and liver of mice in Rehmanniae Radix group while in pancreas, kidney and liver in Rehmanniae Radix Praeparata group. This suggests that Rehmanniae Radix and Rehmanniae Radix Praeparata differ in the mechanism of regulating energy metabolism of multiple organs and thereby exerting anti-inflammatory effects to alleviate symptoms of diabetic mice." @default.
- W4200437612 created "2021-12-31" @default.
- W4200437612 creator A5009438631 @default.
- W4200437612 creator A5013171331 @default.
- W4200437612 creator A5021636467 @default.
- W4200437612 creator A5023901114 @default.
- W4200437612 creator A5033915750 @default.
- W4200437612 creator A5051431915 @default.
- W4200437612 creator A5054449046 @default.
- W4200437612 creator A5061567700 @default.
- W4200437612 date "2021-11-01" @default.
- W4200437612 modified "2023-09-28" @default.
- W4200437612 title "[Rehmanniae Radix and Rehmanniae Radix Praeparata improve diabetes induced by high-fat diet coupled with streptozotocin in mice through AMPK-mediated NF-κB/NLRP3 signaling pathway]." @default.
- W4200437612 doi "https://doi.org/10.19540/j.cnki.cjcmm.20210323.302" @default.
- W4200437612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34951216" @default.
- W4200437612 hasPublicationYear "2021" @default.
- W4200437612 type Work @default.
- W4200437612 citedByCount "3" @default.
- W4200437612 countsByYear W42004376122023 @default.
- W4200437612 crossrefType "journal-article" @default.
- W4200437612 hasAuthorship W4200437612A5009438631 @default.
- W4200437612 hasAuthorship W4200437612A5013171331 @default.
- W4200437612 hasAuthorship W4200437612A5021636467 @default.
- W4200437612 hasAuthorship W4200437612A5023901114 @default.
- W4200437612 hasAuthorship W4200437612A5033915750 @default.
- W4200437612 hasAuthorship W4200437612A5051431915 @default.
- W4200437612 hasAuthorship W4200437612A5054449046 @default.
- W4200437612 hasAuthorship W4200437612A5061567700 @default.
- W4200437612 hasConcept C126322002 @default.
- W4200437612 hasConcept C134018914 @default.
- W4200437612 hasConcept C184235292 @default.
- W4200437612 hasConcept C185592680 @default.
- W4200437612 hasConcept C2779280383 @default.
- W4200437612 hasConcept C2780091579 @default.
- W4200437612 hasConcept C2780124434 @default.
- W4200437612 hasConcept C2780159080 @default.
- W4200437612 hasConcept C55493867 @default.
- W4200437612 hasConcept C555293320 @default.
- W4200437612 hasConcept C71924100 @default.
- W4200437612 hasConcept C97029542 @default.
- W4200437612 hasConceptScore W4200437612C126322002 @default.
- W4200437612 hasConceptScore W4200437612C134018914 @default.
- W4200437612 hasConceptScore W4200437612C184235292 @default.
- W4200437612 hasConceptScore W4200437612C185592680 @default.
- W4200437612 hasConceptScore W4200437612C2779280383 @default.
- W4200437612 hasConceptScore W4200437612C2780091579 @default.
- W4200437612 hasConceptScore W4200437612C2780124434 @default.
- W4200437612 hasConceptScore W4200437612C2780159080 @default.
- W4200437612 hasConceptScore W4200437612C55493867 @default.
- W4200437612 hasConceptScore W4200437612C555293320 @default.
- W4200437612 hasConceptScore W4200437612C71924100 @default.
- W4200437612 hasConceptScore W4200437612C97029542 @default.
- W4200437612 hasIssue "21" @default.
- W4200437612 hasLocation W42004376121 @default.
- W4200437612 hasOpenAccess W4200437612 @default.
- W4200437612 hasPrimaryLocation W42004376121 @default.
- W4200437612 hasRelatedWork W12036438 @default.
- W4200437612 hasRelatedWork W15493126 @default.
- W4200437612 hasRelatedWork W17481905 @default.
- W4200437612 hasRelatedWork W20222512 @default.
- W4200437612 hasRelatedWork W20583319 @default.
- W4200437612 hasRelatedWork W20847208 @default.
- W4200437612 hasRelatedWork W3156605 @default.
- W4200437612 hasRelatedWork W5596178 @default.
- W4200437612 hasRelatedWork W7312398 @default.
- W4200437612 hasRelatedWork W8518807 @default.
- W4200437612 hasVolume "46" @default.
- W4200437612 isParatext "false" @default.
- W4200437612 isRetracted "false" @default.
- W4200437612 workType "article" @default.