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- W4200437705 abstract "Many endoparasitoids adopt several parasitic factors, such as venom, polydnavirus and teratocytes, to suppress the immune response of their associated hosts including melanization for successful parasitism. A teratocyte-specific expressed serpin gene, designated as CvT-serpin6, was identified from the parasitoid Cotesia vestalis. The immunoblot result suggested that CvT-serpin6 was secreted into extracellular space. qPCR results showed that CvT-serpin6 was mainly transcribed at later stages of parasitism, and the transcriptional abundance of CvT-serpin6 in teratocytes was significantly increased in response to the challenge of bacteria. Inhibitory assay indicated that recombinant CvT-serpin6 (rCvT-serpin6) could inhibit the activation of Plutella xylostella prophenoloxidase and ultimately resulted in the inhibition of melanization in P. xylostella haemolymph. Furthermore, we confirmed that rCvT-serpin6 could form SDS-stable complexes with activated PxPAP1 and PxPAP3 in a dose-dependent manner. Altogether, our results further shed insight into the molecular mechanisms that teratocytes involved in controlling host immune response." @default.
- W4200437705 created "2021-12-31" @default.
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- W4200437705 date "2021-12-28" @default.
- W4200437705 modified "2023-10-17" @default.
- W4200437705 title "A teratocyte‐specific serpin from the endoparasitoid wasp <i>Cotesia vestalis</i> inhibits the prophenoloxidase‐activating system of its host <i>Plutella xylostella</i>" @default.
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- W4200437705 doi "https://doi.org/10.1111/imb.12751" @default.
- W4200437705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34897868" @default.
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