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• W4200439800 abstract "Abstract Although cellular senescence is increasingly recognized as driving multiple age-related co-morbidities through the senescence-associated secretory phenotype (SASP), in vivo senescent cell identification, particularly in bulk or single cell RNA-sequencing (scRNA-seq) data remains challenging. Here, we generated a novel gene set (SenMayo) and first validated its enrichment in bone biopsies from two aged human cohorts. SenMayo also identified senescent cells in aged murine brain tissue, demonstrating applicability across tissues and species. For direct validation, we demonstrated significant reductions in SenMayo in bone following genetic clearance of senescent cells in mice, with similar findings in adipose tissue from humans in a pilot study of pharmacological senescent cell clearance. In direct comparisons, SenMayo outperformed all six existing senescence/SASP gene sets in identifying senescent cells across tissues and in demonstrating responses to senescent cell clearance. We next used SenMayo to identify senescent hematopoietic or mesenchymal cells at the single cell level from publicly available human and murine bone marrow/bone scRNA-seq data and identified monocytic and osteolineage cells, respectively, as showing the highest levels of senescence/SASP genes. Using pseudotime and cellular communication patterns, we found senescent hematopoietic and mesenchymal cells communicated with other cells through common pathways, including the Macrophage Migration Inhibitory Factor (MIF) pathway, which has been implicated not only in inflammation but also in immune evasion, an important property of senescent cells. Thus, SenMayo identifies senescent cells across tissues and species with high fidelity. Moreover, using this senescence panel, we were able to characterize senescent cells at the single cell level and identify key intercellular signaling pathways associated with these cells, which may be particularly useful for evolving efforts to map senescent cells ( e.g ., SenNet). In addition, SenMayo represents a potentially clinically applicable panel for monitoring senescent cell burden with aging and other conditions as well as in studies of senolytic drugs." @default.
• W4200439800 created "2021-12-31" @default.
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• W4200439800 date "2021-12-11" @default.
• W4200439800 modified "2023-10-12" @default.
• W4200439800 title "A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues" @default.
• W4200439800 cites W1758822526 @default.
• W4200439800 cites W1970924670 @default.
• W4200439800 cites W1984883254 @default.
• W4200439800 cites W1984936995 @default.
• W4200439800 cites W2010417927 @default.
• W4200439800 cites W2024209230 @default.
• W4200439800 cites W2027000550 @default.
• W4200439800 cites W2049691960 @default.
• W4200439800 cites W2059556222 @default.
• W4200439800 cites W2064871936 @default.
• W4200439800 cites W2097049162 @default.
• W4200439800 cites W2108700752 @default.
• W4200439800 cites W2108887402 @default.
• W4200439800 cites W2111378495 @default.
• W4200439800 cites W2115852450 @default.
• W4200439800 cites W2123106337 @default.
• W4200439800 cites W2125764628 @default.
• W4200439800 cites W2127506701 @default.
• W4200439800 cites W2128807350 @default.
• W4200439800 cites W2130410032 @default.
• W4200439800 cites W2140930678 @default.
• W4200439800 cites W2150748567 @default.
• W4200439800 cites W2150940840 @default.
• W4200439800 cites W2152877666 @default.
• W4200439800 cites W2159675211 @default.
• W4200439800 cites W2256201617 @default.
• W4200439800 cites W2266900518 @default.
• W4200439800 cites W2403934794 @default.
• W4200439800 cites W2422879816 @default.
• W4200439800 cites W2467271588 @default.
• W4200439800 cites W2530549727 @default.
• W4200439800 cites W2560805164 @default.
• W4200439800 cites W2605674430 @default.
• W4200439800 cites W2747877289 @default.
• W4200439800 cites W2749511637 @default.
• W4200439800 cites W2750509325 @default.
• W4200439800 cites W2886406130 @default.
• W4200439800 cites W2888337141 @default.
• W4200439800 cites W2889594596 @default.
• W4200439800 cites W2893877805 @default.
• W4200439800 cites W2900546567 @default.
• W4200439800 cites W2909117878 @default.
• W4200439800 cites W2910111050 @default.
• W4200439800 cites W2912918280 @default.
• W4200439800 cites W2938366281 @default.
• W4200439800 cites W2946721812 @default.
• W4200439800 cites W2949800632 @default.
• W4200439800 cites W2952382191 @default.
• W4200439800 cites W2958555575 @default.
• W4200439800 cites W2961784779 @default.
• W4200439800 cites W2965258110 @default.
• W4200439800 cites W2974643180 @default.
• W4200439800 cites W2975355706 @default.
• W4200439800 cites W2980334082 @default.
• W4200439800 cites W2981455886 @default.
• W4200439800 cites W2997102017 @default.
• W4200439800 cites W2999743411 @default.
• W4200439800 cites W3000364256 @default.
• W4200439800 cites W3001542044 @default.
• W4200439800 cites W3005127469 @default.
• W4200439800 cites W3011207561 @default.
• W4200439800 cites W3012054349 @default.
• W4200439800 cites W3013790306 @default.
• W4200439800 cites W3014402470 @default.
• W4200439800 cites W3015013495 @default.
• W4200439800 cites W3015049822 @default.
• W4200439800 cites W3026206677 @default.
• W4200439800 cites W3033290823 @default.
• W4200439800 cites W3036659787 @default.
• W4200439800 cites W3042236956 @default.
• W4200439800 cites W3042406747 @default.
• W4200439800 cites W3042896257 @default.
• W4200439800 cites W3084134338 @default.
• W4200439800 cites W3095959901 @default.
• W4200439800 cites W3097963524 @default.
• W4200439800 cites W3107344158 @default.

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