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• W4200440671 startingPage "154" @default.
• W4200440671 abstract "During recent years, a number of new compounds against HER2 have reached clinics, improving the prognosis and quality of life of HER2-positive breast cancer patients. Nonetheless, resistance to standard-of-care drugs has motivated the development of novel agents, such as new antibody-drug conjugates (ADCs). The latter are a group of drugs that benefit from the potency of cytotoxic agents whose action is specifically guided to the tumor by the target-specific antibody. Two anti-HER2 ADCs have reached the clinic: trastuzumab-emtansine and, more recently, trastuzumab-deruxtecan. In addition, several other HER2-targeted ADCs are in preclinical or clinical development, some of them with promising signs of activity. In the present review, the structure, mechanism of action, and potential resistance to all these ADCs will be described. Specific attention will be given to discussing novel strategies to circumvent resistance to ADCs." @default.
• W4200440671 created "2021-12-31" @default.
• W4200440671 creator A5012181222 @default.
• W4200440671 creator A5013496439 @default.
• W4200440671 creator A5054921200 @default.
• W4200440671 creator A5074810713 @default.
• W4200440671 date "2021-12-29" @default.
• W4200440671 modified "2023-10-18" @default.
• W4200440671 title "Novel ADCs and Strategies to Overcome Resistance to Anti-HER2 ADCs" @default.
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