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- W4200441617 abstract "Nephrin is a protein identified in the glomerular podocyte slit diaphragm; therefore, the presence of nephrin in urine implies damage to podocytes. Nephrin has been widely studied in nephropathies and glomerular diseases in adults. This study aimed to determine the efficacy of nephrin as a biomarker in maternal urine for the prediction of preeclampsia. This prospective study included pregnant women who had been admitted for delivery at Seoul National University Bundang Hospital between March 2019 and May 2020. The target sample size was 50 patients with confirmed preeclampsia and 50 patients without any underlying diseases. Urine samples were obtained, and nephrin signaling was detected through the test strips using a lateral flow assay. Other relevant clinical data were also collected. The clinical characteristics including maternal age, rate of nulliparity, rate of twin pregnancies, height, weight, and rate of cesarean section were comparable between the control group and the preeclampsia group. Nephrin signals were classified into four groups. In the preeclampsia group, signals 0, 1, 2, and 3 were found in 18.4% (9/49), 44.9% (22/49), 24.5% (12/49), and 12.2% (6/49), respectively. This was significantly different from the control group, in which 84.3% (43/51) were found to be signal 0 (P< 0.001). The sensitivity, specificity, positive predictive value, and negative predictive value of positive signals (1, 2, and 3) to predict preeclampsia were 82%, 84%, 83%, and 83%, respectively. Nephrin signaling in maternal urine might be an easy and accurate screening test for the early detection of preeclampsia.View Large Image Figure ViewerDownload Hi-res image Download (PPT)" @default.
- W4200441617 created "2021-12-31" @default.
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- W4200441617 date "2022-01-01" @default.
- W4200441617 modified "2023-10-05" @default.
- W4200441617 title "Nephrin in maternal urine as a simple biomarker to predict preeclampsia" @default.
- W4200441617 doi "https://doi.org/10.1016/j.ajog.2021.11.207" @default.
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