FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200443799> ?p ?o ?g. }

• W4200443799 endingPage "116284" @default.
• W4200443799 startingPage "116284" @default.
• W4200443799 abstract "Fracture risk is most frequently assessed using Dual X-ray absorptiometry to measure areal bone mineral density (aBMD) and using the Fracture Risk Assessment Tool (FRAX). However, these approaches have limitations and additional bone measurements may enhance the predictive ability of these existing tools. Increased cortical porosity has been associated with incident fracture in some studies, but not in others. In this prospective study, we examined whether cortical bone structure of the proximal femur predicts incident fractures independent of aBMD and FRAX score.We pooled 211 postmenopausal women with fractures aged 54-94 years at baseline and 232 fracture-free age-matched controls based on a prior nested case-control study from the Tromsø Study in Norway. We assessed baseline femoral neck (FN) aBMD, calculated FRAX 10-year probability of major osteoporotic fracture (MOF), and quantified femoral subtrochanteric cortical parameters: porosity, area, thickness, and volumetric BMD (vBMD) from CT images using the StrAx1.0 software. Associations between bone parameters and any incident fracture, MOF and hip fracture were determined using Cox's proportional hazard models to calculate hazard ratio (HR) with 95% confidence interval.During a median follow-up of 7.2 years, 114 (25.7%) of 443 women suffered one or more incident fracture. Cortical bone structure did not predict any incident fracture or MOF after adjustment for age, BMI, and previous fracture. Each SD higher total cortical porosity, thinner cortices, and lower cortical vBMD predicted hip fracture with increased risk of 46-62% (HRs ranging from 1.46 (1.01-2.11) to 1.62 (1.02-2.57)). After adjustment for FN aBMD or FRAX score no association remained significant. Both lower FN aBMD and higher FRAX score predicted any incident fracture, MOF and hip fractures with HRs ranging from 1.45-2.56.This study showed that cortical bone measurements using clinical CT did not add substantial insight into fracture risk beyond FN aBMD and FRAX. We infer from these results that fracture risk related to the deteriorated bone structure seems to be largely captured by a measurement of FN aBMD and the FRAX tool." @default.
• W4200443799 created "2021-12-31" @default.
• W4200443799 creator A5010861098 @default.
• W4200443799 creator A5014835903 @default.
• W4200443799 creator A5022293720 @default.
• W4200443799 creator A5068424697 @default.
• W4200443799 creator A5091486515 @default.
• W4200443799 date "2022-02-01" @default.
• W4200443799 modified "2023-10-18" @default.
• W4200443799 title "Cortical bone structure of the proximal femur and incident fractures" @default.
• W4200443799 cites W1550627712 @default.
• W4200443799 cites W1587583539 @default.
• W4200443799 cites W1589683150 @default.
• W4200443799 cites W2003882637 @default.
• W4200443799 cites W2007752694 @default.
• W4200443799 cites W2021693450 @default.
• W4200443799 cites W2026218910 @default.
• W4200443799 cites W2029109473 @default.
• W4200443799 cites W2042988597 @default.
• W4200443799 cites W2049782133 @default.
• W4200443799 cites W2065231653 @default.
• W4200443799 cites W2065509691 @default.
• W4200443799 cites W2068947159 @default.
• W4200443799 cites W2072820122 @default.
• W4200443799 cites W2112667575 @default.
• W4200443799 cites W2116605720 @default.
• W4200443799 cites W2133304451 @default.
• W4200443799 cites W2337334960 @default.
• W4200443799 cites W2544291754 @default.
• W4200443799 cites W2579596656 @default.
• W4200443799 cites W2585105223 @default.
• W4200443799 cites W2591678938 @default.
• W4200443799 cites W2594042697 @default.
• W4200443799 cites W2759210399 @default.
• W4200443799 cites W2792726429 @default.
• W4200443799 cites W2801595462 @default.
• W4200443799 cites W2902807692 @default.
• W4200443799 cites W2910198883 @default.
• W4200443799 cites W2973632969 @default.
• W4200443799 doi "https://doi.org/10.1016/j.bone.2021.116284" @default.
• W4200443799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34875395" @default.
• W4200443799 hasPublicationYear "2022" @default.
• W4200443799 type Work @default.
• W4200443799 citedByCount "5" @default.
• W4200443799 countsByYear W42004437992022 @default.
• W4200443799 countsByYear W42004437992023 @default.
• W4200443799 crossrefType "journal-article" @default.
• W4200443799 hasAuthorship W4200443799A5010861098 @default.
• W4200443799 hasAuthorship W4200443799A5014835903 @default.
• W4200443799 hasAuthorship W4200443799A5022293720 @default.
• W4200443799 hasAuthorship W4200443799A5068424697 @default.
• W4200443799 hasAuthorship W4200443799A5091486515 @default.
• W4200443799 hasBestOaLocation W42004437991 @default.
• W4200443799 hasConcept C105702510 @default.
• W4200443799 hasConcept C126322002 @default.
• W4200443799 hasConcept C141071460 @default.
• W4200443799 hasConcept C159985019 @default.
• W4200443799 hasConcept C188816634 @default.
• W4200443799 hasConcept C192562407 @default.
• W4200443799 hasConcept C199343813 @default.
• W4200443799 hasConcept C207103383 @default.
• W4200443799 hasConcept C2775854910 @default.
• W4200443799 hasConcept C2776541429 @default.
• W4200443799 hasConcept C2776886416 @default.
• W4200443799 hasConcept C2777525943 @default.
• W4200443799 hasConcept C2778885795 @default.
• W4200443799 hasConcept C2779329777 @default.
• W4200443799 hasConcept C2780554211 @default.
• W4200443799 hasConcept C2781451080 @default.
• W4200443799 hasConcept C29694066 @default.
• W4200443799 hasConcept C2989005 @default.
• W4200443799 hasConcept C2994343686 @default.
• W4200443799 hasConcept C43369102 @default.
• W4200443799 hasConcept C44249647 @default.
• W4200443799 hasConcept C50382708 @default.
• W4200443799 hasConcept C71924100 @default.
• W4200443799 hasConceptScore W4200443799C105702510 @default.
• W4200443799 hasConceptScore W4200443799C126322002 @default.
• W4200443799 hasConceptScore W4200443799C141071460 @default.
• W4200443799 hasConceptScore W4200443799C159985019 @default.
• W4200443799 hasConceptScore W4200443799C188816634 @default.
• W4200443799 hasConceptScore W4200443799C192562407 @default.
• W4200443799 hasConceptScore W4200443799C199343813 @default.
• W4200443799 hasConceptScore W4200443799C207103383 @default.
• W4200443799 hasConceptScore W4200443799C2775854910 @default.
• W4200443799 hasConceptScore W4200443799C2776541429 @default.
• W4200443799 hasConceptScore W4200443799C2776886416 @default.
• W4200443799 hasConceptScore W4200443799C2777525943 @default.
• W4200443799 hasConceptScore W4200443799C2778885795 @default.
• W4200443799 hasConceptScore W4200443799C2779329777 @default.
• W4200443799 hasConceptScore W4200443799C2780554211 @default.
• W4200443799 hasConceptScore W4200443799C2781451080 @default.
• W4200443799 hasConceptScore W4200443799C29694066 @default.
• W4200443799 hasConceptScore W4200443799C2989005 @default.
• W4200443799 hasConceptScore W4200443799C2994343686 @default.
• W4200443799 hasConceptScore W4200443799C43369102 @default.
• W4200443799 hasConceptScore W4200443799C44249647 @default.
• W4200443799 hasConceptScore W4200443799C50382708 @default.

• next