Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200444359> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4200444359 abstract "The gene family of insect odorant receptors (ORs) has greatly expanded in the course of evolution. ORs allow insects to detect volatile chemicals and therefore play an important role in social interactions, the detection of enemies and preys, and during foraging. The sequences of several thousand ORs are known, but their specific function or ligands have been identified only for very few of them. To advance the functional characterization of ORs, we compiled, curated and aligned the sequences of 3,902 ORs from 21 insect species. We identified the amino acid positions that best predict the response to ligands using machine learning on sets of functionally characterized proteins from the fly Drosophila melanogaster, the mosquito Anopheles gambiae and the ant Harpegnathos saltator. We studied the conservation of these predicted relevant residues across all OR subfamilies and show that the subfamilies that expanded strongly in social insects exhibit high levels of conservation in their binding sites. This indicates that ORs of social insect families are typically finely tuned and exhibit a sensitivity to very similar odorants. Our novel approach provides a powerful tool to use functional information from a limited number of genes to investigate the functional evolution of large gene families." @default.
- W4200444359 created "2021-12-31" @default.
- W4200444359 creator A5002515650 @default.
- W4200444359 creator A5010178662 @default.
- W4200444359 creator A5021801715 @default.
- W4200444359 creator A5043082179 @default.
- W4200444359 creator A5055724941 @default.
- W4200444359 creator A5078521810 @default.
- W4200444359 creator A5079122723 @default.
- W4200444359 date "2021-12-10" @default.
- W4200444359 modified "2023-10-16" @default.
- W4200444359 title "Identification of functional residues using machine learning provides insights into the evolution of odorant receptor gene families in solitary and social insects" @default.
- W4200444359 doi "https://doi.org/10.1101/2021.12.10.472060" @default.
- W4200444359 hasPublicationYear "2021" @default.
- W4200444359 type Work @default.
- W4200444359 citedByCount "0" @default.
- W4200444359 crossrefType "posted-content" @default.
- W4200444359 hasAuthorship W4200444359A5002515650 @default.
- W4200444359 hasAuthorship W4200444359A5010178662 @default.
- W4200444359 hasAuthorship W4200444359A5021801715 @default.
- W4200444359 hasAuthorship W4200444359A5043082179 @default.
- W4200444359 hasAuthorship W4200444359A5055724941 @default.
- W4200444359 hasAuthorship W4200444359A5078521810 @default.
- W4200444359 hasAuthorship W4200444359A5079122723 @default.
- W4200444359 hasBestOaLocation W42004443591 @default.
- W4200444359 hasConcept C104317684 @default.
- W4200444359 hasConcept C14036430 @default.
- W4200444359 hasConcept C141231307 @default.
- W4200444359 hasConcept C158471640 @default.
- W4200444359 hasConcept C165287380 @default.
- W4200444359 hasConcept C18903297 @default.
- W4200444359 hasConcept C203014093 @default.
- W4200444359 hasConcept C2776041557 @default.
- W4200444359 hasConcept C2776802408 @default.
- W4200444359 hasConcept C2776998849 @default.
- W4200444359 hasConcept C2777612826 @default.
- W4200444359 hasConcept C2778048844 @default.
- W4200444359 hasConcept C2780104201 @default.
- W4200444359 hasConcept C54355233 @default.
- W4200444359 hasConcept C5911399 @default.
- W4200444359 hasConcept C70721500 @default.
- W4200444359 hasConcept C78458016 @default.
- W4200444359 hasConcept C86803240 @default.
- W4200444359 hasConceptScore W4200444359C104317684 @default.
- W4200444359 hasConceptScore W4200444359C14036430 @default.
- W4200444359 hasConceptScore W4200444359C141231307 @default.
- W4200444359 hasConceptScore W4200444359C158471640 @default.
- W4200444359 hasConceptScore W4200444359C165287380 @default.
- W4200444359 hasConceptScore W4200444359C18903297 @default.
- W4200444359 hasConceptScore W4200444359C203014093 @default.
- W4200444359 hasConceptScore W4200444359C2776041557 @default.
- W4200444359 hasConceptScore W4200444359C2776802408 @default.
- W4200444359 hasConceptScore W4200444359C2776998849 @default.
- W4200444359 hasConceptScore W4200444359C2777612826 @default.
- W4200444359 hasConceptScore W4200444359C2778048844 @default.
- W4200444359 hasConceptScore W4200444359C2780104201 @default.
- W4200444359 hasConceptScore W4200444359C54355233 @default.
- W4200444359 hasConceptScore W4200444359C5911399 @default.
- W4200444359 hasConceptScore W4200444359C70721500 @default.
- W4200444359 hasConceptScore W4200444359C78458016 @default.
- W4200444359 hasConceptScore W4200444359C86803240 @default.
- W4200444359 hasLocation W42004443591 @default.
- W4200444359 hasOpenAccess W4200444359 @default.
- W4200444359 hasPrimaryLocation W42004443591 @default.
- W4200444359 hasRelatedWork W2007083730 @default.
- W4200444359 hasRelatedWork W2028423171 @default.
- W4200444359 hasRelatedWork W2060450464 @default.
- W4200444359 hasRelatedWork W2134964329 @default.
- W4200444359 hasRelatedWork W2172076792 @default.
- W4200444359 hasRelatedWork W2408945988 @default.
- W4200444359 hasRelatedWork W4200444359 @default.
- W4200444359 hasRelatedWork W4236915199 @default.
- W4200444359 hasRelatedWork W4238688176 @default.
- W4200444359 hasRelatedWork W4283035092 @default.
- W4200444359 isParatext "false" @default.
- W4200444359 isRetracted "false" @default.
- W4200444359 workType "article" @default.