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• W4200445679 startingPage "114557" @default.
• W4200445679 abstract "Metabolomics, a technique that profiles global small molecules in biological samples, has been a pivotal tool for disease diagnosis and mechanism research. The sample type in metabolomics covers a wide range, including a variety of body fluids, tissues, and cells. However, little attention was paid to the smaller, relatively independent partition systems in cells, namely the organelles. The organelles are specific compartments/places where diverse metabolic activities are happening in an orderly manner. Metabolic disorders of organelles were found to occur in various pathological conditions such as inherited metabolic diseases, diabetes, cancer, and neurodegenerative diseases. However, at the cellular level, the metabolic outcomes of organelles and cytoplasm are superimposed interactively, making it difficult to describe the changes in subcellular compartments. Therefore, characterizing the metabolic pool in the compartmentalized system is of great significance for understanding the role of organelles in physiological functions and diseases. So far, there are very few research articles or reviews related to subcellular metabolomics. In this review, subcellular fractionation and metabolite analysis methods, as well as the application of subcellular metabolomics in the physiological and pathological studies are systematically reviewed, as a practical reference to promote the continued advancement in subcellular metabolomics." @default.
• W4200445679 created "2021-12-31" @default.
• W4200445679 creator A5027143310 @default.
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• W4200445679 creator A5063613049 @default.
• W4200445679 creator A5072914443 @default.
• W4200445679 date "2022-02-01" @default.
• W4200445679 modified "2023-10-18" @default.
• W4200445679 title "Subcellular metabolomics: Isolation, measurement, and applications" @default.
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