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• W4200445863 abstract "•Integrins are heterodimers of α and β subunits. •Major integrin complexes expressed in megakaryocytes include αVβ3, α3β1, and α5β1. •Megakaryocyte integrins play key roles in this lineage development and function. •Some megakaryocyte and platelet pathologies are associated with dysregulated/mutated integrins. •Modulators of megakaryocyte integrin functions have therapeutic potential. Mature megakaryocytes, the platelet precursors, originate from hematopoietic stem cell progenitors, which, once committed to this lineage, undergo endomitosis leading to polyploidization. The process entails repeated rounds of DNA replication without cell division, yielding polyploid cells. Supporting the cell's developmental process and various cellular functions are integrin receptors, a conduit of communication between the extracellular environment and the cell actin cytoskeleton. Integrins are heterodimers of α and β subunits, where different combinations of the known 18 α and 8 β subunits confer specificity to the receptor. Integrin ligands range from extracellular matrices through soluble ligands, infectious agents, and counterreceptors, to cells. In this review, we describe the different integrins expressed on bone marrow megakaryocytes and their attributed roles in lineage development and cellular functions, including adhesion, spreading, proplatelet formation, and functional interaction with other cells. Pathologies associated with dysregulated megakaryocyte integrin expression are also reviewed. Mature megakaryocytes, the platelet precursors, originate from hematopoietic stem cell progenitors, which, once committed to this lineage, undergo endomitosis leading to polyploidization. The process entails repeated rounds of DNA replication without cell division, yielding polyploid cells. Supporting the cell's developmental process and various cellular functions are integrin receptors, a conduit of communication between the extracellular environment and the cell actin cytoskeleton. Integrins are heterodimers of α and β subunits, where different combinations of the known 18 α and 8 β subunits confer specificity to the receptor. Integrin ligands range from extracellular matrices through soluble ligands, infectious agents, and counterreceptors, to cells. In this review, we describe the different integrins expressed on bone marrow megakaryocytes and their attributed roles in lineage development and cellular functions, including adhesion, spreading, proplatelet formation, and functional interaction with other cells. Pathologies associated with dysregulated megakaryocyte integrin expression are also reviewed." @default.
• W4200445863 created "2021-12-31" @default.
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• W4200445863 creator A5056415659 @default.
• W4200445863 creator A5059780085 @default.
• W4200445863 date "2022-02-01" @default.
• W4200445863 modified "2023-10-15" @default.
• W4200445863 title "Integrins and their role in megakaryocyte development and function" @default.
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• W4200445863 doi "https://doi.org/10.1016/j.exphem.2021.11.007" @default.
• W4200445863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34910941" @default.
• W4200445863 hasPublicationYear "2022" @default.
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