Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200449156> ?p ?o ?g. }
- W4200449156 abstract "Despite substantial investment in research and treatment options, diabetes mellitus remains a pressing public health concern with potential epidemic proportions globally. There are reports that by the end of 2040, 642 million people will be suffering from diabetes. Also, according to an estimation, 1.6 million deaths were caused directly by diabetes in 2016. Diabetes is a metabolic disorder characterized by impaired glucose regulation in the body due to the destruction of pancreatic β-cells or insulin resistance. Genetic propensity, unhealthy and imbalanced diet, obesity and increasing urbanization are the common risk factors for diabetes. Besides this, it has been reported that environmental pollutants like organic pesticides, heavy metals, and air pollutants act as strong predisposing factors for diabetes owing to their highly bio-accumulative nature. These pollutants disturb glucose homeostasis either by up-regulating or down-regulating the expression of diabetic marker genes like insulin (INS), glucokinase (GCK). Unfortunately, the molecular mechanism about the role of pollutants in causing diabetes is not very clear. This mechanistic review provides evidence of different environmental determinants including persistent organic pollutants (POPs), air pollutants, toxic metals, etc. in inducing diabetes and proposes a framework for the possible mechanisms involved. It also illuminates the current status and future challenges which will not only broaden our understanding but can also be a reasonable platform for further investigation." @default.
- W4200449156 created "2021-12-31" @default.
- W4200449156 creator A5007951678 @default.
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- W4200449156 creator A5055985981 @default.
- W4200449156 creator A5074130748 @default.
- W4200449156 date "2022-11-01" @default.
- W4200449156 modified "2023-10-14" @default.
- W4200449156 title "Environmental Factors as Diabetic Mediators: A Mechanistic Approach" @default.
- W4200449156 cites W1520184516 @default.
- W4200449156 cites W1534360145 @default.
- W4200449156 cites W1585286042 @default.
- W4200449156 cites W1598767975 @default.
- W4200449156 cites W1664463503 @default.
- W4200449156 cites W1872276237 @default.
- W4200449156 cites W1964268690 @default.
- W4200449156 cites W1967908741 @default.
- W4200449156 cites W1969968971 @default.
- W4200449156 cites W1973042928 @default.
- W4200449156 cites W1973694342 @default.
- W4200449156 cites W1973870797 @default.
- W4200449156 cites W1976814223 @default.
- W4200449156 cites W1977183031 @default.
- W4200449156 cites W1978774658 @default.
- W4200449156 cites W1988849223 @default.
- W4200449156 cites W1990660160 @default.
- W4200449156 cites W1993104325 @default.
- W4200449156 cites W1994469077 @default.
- W4200449156 cites W2000392034 @default.
- W4200449156 cites W2001789499 @default.
- W4200449156 cites W2003978628 @default.
- W4200449156 cites W2004256935 @default.
- W4200449156 cites W2005395908 @default.
- W4200449156 cites W2005559789 @default.
- W4200449156 cites W2006351130 @default.
- W4200449156 cites W2008143869 @default.
- W4200449156 cites W2012423740 @default.
- W4200449156 cites W2013375584 @default.
- W4200449156 cites W2013612914 @default.
- W4200449156 cites W2014150292 @default.
- W4200449156 cites W2015969846 @default.
- W4200449156 cites W2016818302 @default.
- W4200449156 cites W2020048016 @default.
- W4200449156 cites W2024875082 @default.
- W4200449156 cites W2025261524 @default.
- W4200449156 cites W2025764080 @default.
- W4200449156 cites W2026020817 @default.
- W4200449156 cites W2026398980 @default.
- W4200449156 cites W2027364427 @default.
- W4200449156 cites W2028008706 @default.
- W4200449156 cites W2028514363 @default.
- W4200449156 cites W2028722438 @default.
- W4200449156 cites W2032048326 @default.
- W4200449156 cites W2032958713 @default.
- W4200449156 cites W2035278083 @default.
- W4200449156 cites W2037327705 @default.
- W4200449156 cites W2048860233 @default.
- W4200449156 cites W2049416168 @default.
- W4200449156 cites W2053987839 @default.
- W4200449156 cites W2055779552 @default.
- W4200449156 cites W2061962106 @default.
- W4200449156 cites W2062244719 @default.
- W4200449156 cites W2063671038 @default.
- W4200449156 cites W2065540930 @default.
- W4200449156 cites W2066752848 @default.
- W4200449156 cites W2066951928 @default.
- W4200449156 cites W2069254925 @default.
- W4200449156 cites W2071173492 @default.
- W4200449156 cites W2073378182 @default.
- W4200449156 cites W2075231037 @default.
- W4200449156 cites W2083812486 @default.
- W4200449156 cites W2084759031 @default.
- W4200449156 cites W2085994990 @default.
- W4200449156 cites W2087136462 @default.
- W4200449156 cites W2090367776 @default.
- W4200449156 cites W2091584793 @default.
- W4200449156 cites W2094899987 @default.
- W4200449156 cites W2097586518 @default.
- W4200449156 cites W2098325368 @default.
- W4200449156 cites W2098854866 @default.
- W4200449156 cites W2100229266 @default.
- W4200449156 cites W2101418369 @default.
- W4200449156 cites W2103348177 @default.
- W4200449156 cites W2105346598 @default.
- W4200449156 cites W2110052313 @default.
- W4200449156 cites W2110630581 @default.
- W4200449156 cites W2110921823 @default.
- W4200449156 cites W2111496733 @default.
- W4200449156 cites W2113490534 @default.
- W4200449156 cites W2116215510 @default.
- W4200449156 cites W2123900733 @default.
- W4200449156 cites W2126115073 @default.
- W4200449156 cites W2126333961 @default.
- W4200449156 cites W2126705024 @default.
- W4200449156 cites W2128409104 @default.
- W4200449156 cites W2129316761 @default.
- W4200449156 cites W2132003144 @default.
- W4200449156 cites W2132281761 @default.