Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200449351> ?p ?o ?g. }
- W4200449351 endingPage "286" @default.
- W4200449351 startingPage "280" @default.
- W4200449351 abstract "Carbonic anhydrase IX/XII (CA IX/XII), are cell-surface enzymes typically expressed by cancer cells as a form of adaptation to hypoxia and acidosis. It has been widely reported that these proteins play pivotal roles in cancer progression fostering cell migration, aggressiveness and resistance to first line chemo- and radiotherapies. CA IX has emerged as a promising target in cancer therapy and several approaches and families of compounds were characterised in the attempt to find optimal targeting by inhibiting of the high catalytic activity of the enzyme. In the present work, different cell lines representing glioblastoma, bladder and pancreatic cancer have been exploited to compare the inhibitory and antiproliferative effect of primary sulphonamide acetazolamide (AAZ), the Phase Ib/II clinical grade sulphonamide SLC-0111, and a membrane-impermeant positively charged, pyridinium-derivative (C18). New hints regarding the possibility to exploit CA inhibitors in these cancer types are proposed." @default.
- W4200449351 created "2021-12-31" @default.
- W4200449351 creator A5000915955 @default.
- W4200449351 creator A5000996859 @default.
- W4200449351 creator A5013367044 @default.
- W4200449351 creator A5018378636 @default.
- W4200449351 creator A5035013697 @default.
- W4200449351 creator A5080776751 @default.
- W4200449351 date "2021-12-11" @default.
- W4200449351 modified "2023-10-15" @default.
- W4200449351 title "Antiproliferative effects of sulphonamide carbonic anhydrase inhibitors C18, SLC-0111 and acetazolamide on bladder, glioblastoma and pancreatic cancer cell lines" @default.
- W4200449351 cites W1511344577 @default.
- W4200449351 cites W1573899446 @default.
- W4200449351 cites W1973469475 @default.
- W4200449351 cites W1999251458 @default.
- W4200449351 cites W2005277758 @default.
- W4200449351 cites W2034473811 @default.
- W4200449351 cites W2047178318 @default.
- W4200449351 cites W2064193977 @default.
- W4200449351 cites W2072458613 @default.
- W4200449351 cites W2090056732 @default.
- W4200449351 cites W2090559362 @default.
- W4200449351 cites W2133386306 @default.
- W4200449351 cites W2143349422 @default.
- W4200449351 cites W2156387230 @default.
- W4200449351 cites W2471456962 @default.
- W4200449351 cites W2793047804 @default.
- W4200449351 cites W2913679277 @default.
- W4200449351 cites W2914933414 @default.
- W4200449351 cites W2916667463 @default.
- W4200449351 cites W2944600762 @default.
- W4200449351 cites W2953322796 @default.
- W4200449351 cites W3001130933 @default.
- W4200449351 cites W3014500359 @default.
- W4200449351 cites W3024441676 @default.
- W4200449351 cites W3047040017 @default.
- W4200449351 cites W3092990449 @default.
- W4200449351 cites W3094513943 @default.
- W4200449351 cites W3112626892 @default.
- W4200449351 cites W3133227992 @default.
- W4200449351 cites W3135155063 @default.
- W4200449351 cites W3163437223 @default.
- W4200449351 cites W3195000164 @default.
- W4200449351 doi "https://doi.org/10.1080/14756366.2021.2004592" @default.
- W4200449351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34894950" @default.
- W4200449351 hasPublicationYear "2021" @default.
- W4200449351 type Work @default.
- W4200449351 citedByCount "18" @default.
- W4200449351 countsByYear W42004493512022 @default.
- W4200449351 countsByYear W42004493512023 @default.
- W4200449351 crossrefType "journal-article" @default.
- W4200449351 hasAuthorship W4200449351A5000915955 @default.
- W4200449351 hasAuthorship W4200449351A5000996859 @default.
- W4200449351 hasAuthorship W4200449351A5013367044 @default.
- W4200449351 hasAuthorship W4200449351A5018378636 @default.
- W4200449351 hasAuthorship W4200449351A5035013697 @default.
- W4200449351 hasAuthorship W4200449351A5080776751 @default.
- W4200449351 hasBestOaLocation W42004493511 @default.
- W4200449351 hasConcept C121608353 @default.
- W4200449351 hasConcept C126322002 @default.
- W4200449351 hasConcept C181199279 @default.
- W4200449351 hasConcept C185592680 @default.
- W4200449351 hasConcept C2775914622 @default.
- W4200449351 hasConcept C2777405951 @default.
- W4200449351 hasConcept C2780210213 @default.
- W4200449351 hasConcept C502942594 @default.
- W4200449351 hasConcept C54355233 @default.
- W4200449351 hasConcept C55493867 @default.
- W4200449351 hasConcept C71924100 @default.
- W4200449351 hasConcept C81885089 @default.
- W4200449351 hasConcept C86803240 @default.
- W4200449351 hasConcept C96232424 @default.
- W4200449351 hasConceptScore W4200449351C121608353 @default.
- W4200449351 hasConceptScore W4200449351C126322002 @default.
- W4200449351 hasConceptScore W4200449351C181199279 @default.
- W4200449351 hasConceptScore W4200449351C185592680 @default.
- W4200449351 hasConceptScore W4200449351C2775914622 @default.
- W4200449351 hasConceptScore W4200449351C2777405951 @default.
- W4200449351 hasConceptScore W4200449351C2780210213 @default.
- W4200449351 hasConceptScore W4200449351C502942594 @default.
- W4200449351 hasConceptScore W4200449351C54355233 @default.
- W4200449351 hasConceptScore W4200449351C55493867 @default.
- W4200449351 hasConceptScore W4200449351C71924100 @default.
- W4200449351 hasConceptScore W4200449351C81885089 @default.
- W4200449351 hasConceptScore W4200449351C86803240 @default.
- W4200449351 hasConceptScore W4200449351C96232424 @default.
- W4200449351 hasFunder F4320323054 @default.
- W4200449351 hasIssue "1" @default.
- W4200449351 hasLocation W42004493511 @default.
- W4200449351 hasLocation W42004493512 @default.
- W4200449351 hasLocation W42004493513 @default.
- W4200449351 hasLocation W42004493514 @default.
- W4200449351 hasLocation W42004493515 @default.
- W4200449351 hasOpenAccess W4200449351 @default.
- W4200449351 hasPrimaryLocation W42004493511 @default.
- W4200449351 hasRelatedWork W1969904143 @default.
- W4200449351 hasRelatedWork W1994421171 @default.
- W4200449351 hasRelatedWork W2015280585 @default.