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- W4200454311 abstract "Listeria monocytogenes is more heat-resistant than most other non-spore-forming foodborne pathogens, posing a severe threat to food safety and human health, particularly during chilled food processing. The DegU orphan response regulator is known to control heat resistance in L. monocytogenes ; however, the underlying regulatory mechanism is poorly understood. Here, we show that DegU contributes to L. monocytogenes exponential growth under mild heat-shock stress. We further demonstrate that DegU directly senses heat stress through autoregulation and upregulates the hrcA-grpE-dnaK-dnaJ operon, leading to increased production of heat-shock proteins. We also show that DegU can directly regulate the expression of the hrcA-grpE-dnaK-dnaJ operon. In conclusion, our results shed light on the regulatory mechanisms underlying how DegU directly activates the hrcA-grpE-dnaK-dnaJ operon, thereby regulating heat resistance in L. monocytogenes ." @default.
- W4200454311 created "2021-12-31" @default.
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- W4200454311 date "2021-12-13" @default.
- W4200454311 modified "2023-10-12" @default.
- W4200454311 title "The DegU Orphan Response Regulator Contributes to Heat Stress Resistance in Listeria monocytogenes" @default.
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- W4200454311 doi "https://doi.org/10.3389/fcimb.2021.761335" @default.
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