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- W4200459954 endingPage "653" @default.
- W4200459954 startingPage "618" @default.
- W4200459954 abstract "Since nuclear factor of κ-light chain of enhancer-activated B cells (NF-κB) was discovered in 1986, extraordinary efforts have been made to understand the function and regulating mechanism of NF-κB for 35 years, which lead to significant progress. Meanwhile, the molecular mechanisms regulating NF-κB activation have also been illuminated, the cascades of signaling events leading to NF-κB activity and key components of the NF-κB pathway are also identified. It has been suggested NF-κB plays an important role in human diseases, especially inflammation-related diseases. These studies make the NF-κB an attractive target for disease treatment. This review aims to summarize the knowledge of the family members of NF-κB, as well as the basic mechanisms of NF-κB signaling pathway activation. We will also review the effects of dysregulated NF-κB on inflammation, tumorigenesis, and tumor microenvironment. The progression of the translational study and drug development targeting NF-κB for inflammatory diseases and cancer treatment and the potential obstacles will be discussed. Further investigations on the precise functions of NF-κB in the physiological and pathological settings and underlying mechanisms are in the urgent need to develop drugs targeting NF-κB for inflammatory diseases and cancer treatment, with minimal side effects." @default.
- W4200459954 created "2021-12-31" @default.
- W4200459954 creator A5001660190 @default.
- W4200459954 creator A5018805094 @default.
- W4200459954 creator A5057125192 @default.
- W4200459954 creator A5076655622 @default.
- W4200459954 creator A5087527641 @default.
- W4200459954 date "2021-12-01" @default.
- W4200459954 modified "2023-10-15" @default.
- W4200459954 title "NF‐κB signaling in inflammation and cancer" @default.
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