FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200460438> ?p ?o ?g. }

• W4200460438 abstract "Zika virus (ZIKV) is a flavivirus that is mainly transmitted by Aedes mosquitos and normally causes mild symptoms. During the outbreak in the Americas in 2015, it was associated with more severe implications, like microcephaly in newborns and the Guillain-Barré syndrome. The lack of specific vaccines and cures strengthens the need for a deeper understanding of the virus life cycle and virus-host interactions. The restriction factor tetherin (THN) is an interferon-inducible cellular protein with broad antiviral properties. It is known to inhibit the release of various enveloped viruses by tethering them to each other and the cell membrane, thereby preventing their further spread. On the other hand, different viruses have developed various escape strategies against THN. Analysis of the cross-talk between ZIKV and THN revealed that, despite a strong induction of THN mRNA expression in ZIKV-infected cells, this is not reflected by an elevated protein level of THN. Contrariwise, the THN protein level is decreased due to a reduced half-life. The increased degradation of THN in ZIKV infected cells involves the endo-lysosomal system but does not depend on the early steps of autophagy. Enrichment of THN by depletion of the ESCRT-0 protein HRS diminishes ZIKV release and spread, which points out the capacity of THN to restrict ZIKV and explains the enhanced THN degradation in infected cells as an effective viral escape strategy. IMPORTANCE Although tetherin expression is strongly induced by ZIKV infection there is a reduction in the amount of tetherin protein. This is due to enhanced lysosomal degradation. However, if the tetherin level is rescued then the release of ZIKV is impaired. This shows that tetherin is a restriction factor for ZIKV, and the induction of an efficient degradation represents a viral escape strategy. To our knowledge, this is the first study that describes and characterizes tetherin as a restriction factor for the ZIKV life cycle." @default.
• W4200460438 created "2021-12-31" @default.
• W4200460438 creator A5009104427 @default.
• W4200460438 creator A5019835719 @default.
• W4200460438 creator A5021809619 @default.
• W4200460438 creator A5041106782 @default.
• W4200460438 creator A5059826589 @default.
• W4200460438 creator A5066212310 @default.
• W4200460438 creator A5068272541 @default.
• W4200460438 creator A5070704801 @default.
• W4200460438 creator A5071659705 @default.
• W4200460438 creator A5080262638 @default.
• W4200460438 creator A5084718340 @default.
• W4200460438 date "2021-12-22" @default.
• W4200460438 modified "2023-09-26" @default.
• W4200460438 title "Catch me if you can – the crosstalk of ZIKV and the restriction factor Tetherin" @default.
• W4200460438 cites W1514154332 @default.
• W4200460438 cites W1857453373 @default.
• W4200460438 cites W1965157736 @default.
• W4200460438 cites W1973572007 @default.
• W4200460438 cites W1998079639 @default.
• W4200460438 cites W1998332200 @default.
• W4200460438 cites W2002472695 @default.
• W4200460438 cites W2010458160 @default.
• W4200460438 cites W2019725062 @default.
• W4200460438 cites W2024460705 @default.
• W4200460438 cites W2029282862 @default.
• W4200460438 cites W2036161664 @default.
• W4200460438 cites W2043591953 @default.
• W4200460438 cites W2043892409 @default.
• W4200460438 cites W2049018382 @default.
• W4200460438 cites W2062611394 @default.
• W4200460438 cites W2065276673 @default.
• W4200460438 cites W2076913288 @default.
• W4200460438 cites W2085335543 @default.
• W4200460438 cites W2095640275 @default.
• W4200460438 cites W2101352435 @default.
• W4200460438 cites W2104192104 @default.
• W4200460438 cites W2115079016 @default.
• W4200460438 cites W2116737541 @default.
• W4200460438 cites W2120231116 @default.
• W4200460438 cites W2164439474 @default.
• W4200460438 cites W2336892636 @default.
• W4200460438 cites W2496850373 @default.
• W4200460438 cites W2507412157 @default.
• W4200460438 cites W2525254279 @default.
• W4200460438 cites W2529794991 @default.
• W4200460438 cites W2592647402 @default.
• W4200460438 cites W2735680761 @default.
• W4200460438 cites W2766597872 @default.
• W4200460438 cites W2774432119 @default.
• W4200460438 cites W2786313719 @default.
• W4200460438 cites W2799769362 @default.
• W4200460438 cites W2805570396 @default.
• W4200460438 cites W2896398979 @default.
• W4200460438 cites W2907960228 @default.
• W4200460438 cites W2914814089 @default.
• W4200460438 cites W2915459788 @default.
• W4200460438 cites W2940184969 @default.
• W4200460438 cites W2946841087 @default.
• W4200460438 cites W2948077069 @default.
• W4200460438 cites W2967150134 @default.
• W4200460438 cites W2985816706 @default.
• W4200460438 cites W3004359313 @default.
• W4200460438 cites W3011730446 @default.
• W4200460438 cites W3015805258 @default.
• W4200460438 cites W3045645539 @default.
• W4200460438 cites W3096130367 @default.
• W4200460438 cites W3122933575 @default.
• W4200460438 cites W3188354136 @default.
• W4200460438 cites W4210471029 @default.
• W4200460438 cites W4210967474 @default.
• W4200460438 cites W4239275885 @default.
• W4200460438 doi "https://doi.org/10.1128/jvi.02117-21" @default.
• W4200460438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34935441" @default.
• W4200460438 hasPublicationYear "2021" @default.
• W4200460438 type Work @default.
• W4200460438 citedByCount "0" @default.
• W4200460438 crossrefType "journal-article" @default.
• W4200460438 hasAuthorship W4200460438A5009104427 @default.
• W4200460438 hasAuthorship W4200460438A5019835719 @default.
• W4200460438 hasAuthorship W4200460438A5021809619 @default.
• W4200460438 hasAuthorship W4200460438A5041106782 @default.
• W4200460438 hasAuthorship W4200460438A5059826589 @default.
• W4200460438 hasAuthorship W4200460438A5066212310 @default.
• W4200460438 hasAuthorship W4200460438A5068272541 @default.
• W4200460438 hasAuthorship W4200460438A5070704801 @default.
• W4200460438 hasAuthorship W4200460438A5071659705 @default.
• W4200460438 hasAuthorship W4200460438A5080262638 @default.
• W4200460438 hasAuthorship W4200460438A5084718340 @default.
• W4200460438 hasBestOaLocation W42004604382 @default.
• W4200460438 hasConcept C104317684 @default.
• W4200460438 hasConcept C156719811 @default.
• W4200460438 hasConcept C159047783 @default.
• W4200460438 hasConcept C190283241 @default.
• W4200460438 hasConcept C203522944 @default.
• W4200460438 hasConcept C2522874641 @default.
• W4200460438 hasConcept C2776315342 @default.
• W4200460438 hasConcept C2776855506 @default.
• W4200460438 hasConcept C2777053367 @default.

• next