FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200460614> ?p ?o ?g. }

• W4200460614 endingPage "144" @default.
• W4200460614 startingPage "139" @default.
• W4200460614 abstract "In Brazil, the major vector of arboviruses is Aedes aegypti, which can transmit several alpha and flaviviruses. In this work, a pacifastin protease inhibitor library was constructed and used to select mutants for Ae. aegypti larvae digestive enzymes. The library contained a total of 3.25 × 105 cfu with random mutations in the reactive site (P2-P2'). The most successfully selected mutant, TiPI6, a versatile inhibitor, was able to inhibit all three Ae. aegypti larvae proteolytic activities, trypsin-like, chymotrypsin-like and elastase-like activities, with IC50 values of 0.212 nM, 0.107 nM and 0.109 nM, respectively. In conclusion, the TiPI mutated phage display library was shown to be a useful tool for the selection of an inhibitor of proteolytic activities combined in a mix. TiPI6 is capable of controlling all three digestive enzyme activities present in the larval midgut extract. To our knowledge, this is the first time that one inhibitor containing a Gln at the P1 position showed inhibitory activity against trypsin, chymotrypsin, and elastase-like activities. TiPI6 can be a candidate for further larvicidal studies." @default.
• W4200460614 created "2021-12-31" @default.
• W4200460614 creator A5024812878 @default.
• W4200460614 creator A5027516009 @default.
• W4200460614 creator A5054262322 @default.
• W4200460614 creator A5063834538 @default.
• W4200460614 creator A5071857385 @default.
• W4200460614 creator A5082887357 @default.
• W4200460614 date "2022-01-01" @default.
• W4200460614 modified "2023-10-17" @default.
• W4200460614 title "A versatile inhibitor of digestive enzymes in Aedes aegypti larvae selected from a pacifastin (TiPI) phage display library" @default.
• W4200460614 cites W1645592971 @default.
• W4200460614 cites W1923665401 @default.
• W4200460614 cites W1972107927 @default.
• W4200460614 cites W1985469117 @default.
• W4200460614 cites W1987120649 @default.
• W4200460614 cites W2023920013 @default.
• W4200460614 cites W2024097785 @default.
• W4200460614 cites W2062174388 @default.
• W4200460614 cites W2071421061 @default.
• W4200460614 cites W2072963615 @default.
• W4200460614 cites W2077451485 @default.
• W4200460614 cites W2079530113 @default.
• W4200460614 cites W2095574104 @default.
• W4200460614 cites W2159740972 @default.
• W4200460614 cites W2401913595 @default.
• W4200460614 cites W2568134545 @default.
• W4200460614 cites W2800611293 @default.
• W4200460614 cites W2805783242 @default.
• W4200460614 cites W2806217711 @default.
• W4200460614 cites W2808368862 @default.
• W4200460614 cites W2914077326 @default.
• W4200460614 cites W3028755523 @default.
• W4200460614 cites W4211045835 @default.
• W4200460614 doi "https://doi.org/10.1016/j.bbrc.2021.12.087" @default.
• W4200460614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34974302" @default.
• W4200460614 hasPublicationYear "2022" @default.
• W4200460614 type Work @default.
• W4200460614 citedByCount "1" @default.
• W4200460614 countsByYear W42004606142023 @default.
• W4200460614 crossrefType "journal-article" @default.
• W4200460614 hasAuthorship W4200460614A5024812878 @default.
• W4200460614 hasAuthorship W4200460614A5027516009 @default.
• W4200460614 hasAuthorship W4200460614A5054262322 @default.
• W4200460614 hasAuthorship W4200460614A5063834538 @default.
• W4200460614 hasAuthorship W4200460614A5071857385 @default.
• W4200460614 hasAuthorship W4200460614A5082887357 @default.
• W4200460614 hasConcept C104317684 @default.
• W4200460614 hasConcept C142462285 @default.
• W4200460614 hasConcept C143065580 @default.
• W4200460614 hasConcept C150149183 @default.
• W4200460614 hasConcept C153911025 @default.
• W4200460614 hasConcept C159047783 @default.
• W4200460614 hasConcept C173758957 @default.
• W4200460614 hasConcept C181199279 @default.
• W4200460614 hasConcept C186268636 @default.
• W4200460614 hasConcept C2522874641 @default.
• W4200460614 hasConcept C2776714187 @default.
• W4200460614 hasConcept C2777775583 @default.
• W4200460614 hasConcept C2777807008 @default.
• W4200460614 hasConcept C2778401398 @default.
• W4200460614 hasConcept C2779281246 @default.
• W4200460614 hasConcept C2780340462 @default.
• W4200460614 hasConcept C2781044401 @default.
• W4200460614 hasConcept C2781143361 @default.
• W4200460614 hasConcept C2993143319 @default.
• W4200460614 hasConcept C3019223276 @default.
• W4200460614 hasConcept C55493867 @default.
• W4200460614 hasConcept C59822182 @default.
• W4200460614 hasConcept C86803240 @default.
• W4200460614 hasConceptScore W4200460614C104317684 @default.
• W4200460614 hasConceptScore W4200460614C142462285 @default.
• W4200460614 hasConceptScore W4200460614C143065580 @default.
• W4200460614 hasConceptScore W4200460614C150149183 @default.
• W4200460614 hasConceptScore W4200460614C153911025 @default.
• W4200460614 hasConceptScore W4200460614C159047783 @default.
• W4200460614 hasConceptScore W4200460614C173758957 @default.
• W4200460614 hasConceptScore W4200460614C181199279 @default.
• W4200460614 hasConceptScore W4200460614C186268636 @default.
• W4200460614 hasConceptScore W4200460614C2522874641 @default.
• W4200460614 hasConceptScore W4200460614C2776714187 @default.
• W4200460614 hasConceptScore W4200460614C2777775583 @default.
• W4200460614 hasConceptScore W4200460614C2777807008 @default.
• W4200460614 hasConceptScore W4200460614C2778401398 @default.
• W4200460614 hasConceptScore W4200460614C2779281246 @default.
• W4200460614 hasConceptScore W4200460614C2780340462 @default.
• W4200460614 hasConceptScore W4200460614C2781044401 @default.
• W4200460614 hasConceptScore W4200460614C2781143361 @default.
• W4200460614 hasConceptScore W4200460614C2993143319 @default.
• W4200460614 hasConceptScore W4200460614C3019223276 @default.
• W4200460614 hasConceptScore W4200460614C55493867 @default.
• W4200460614 hasConceptScore W4200460614C59822182 @default.
• W4200460614 hasConceptScore W4200460614C86803240 @default.
• W4200460614 hasLocation W42004606141 @default.
• W4200460614 hasLocation W42004606142 @default.
• W4200460614 hasOpenAccess W4200460614 @default.
• W4200460614 hasPrimaryLocation W42004606141 @default.
• W4200460614 hasRelatedWork W1768478667 @default.

• next