FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200461195> ?p ?o ?g. }

• W4200461195 endingPage "108489" @default.
• W4200461195 startingPage "108489" @default.
• W4200461195 abstract "Resveratrol has shown pleiotropic effects against inflammation and oxidative response. The present study aimed to investigate the effects and mechanisms of resveratrol on fungus-induced allergic airway inflammation.Female BALB/c mice were injected intraperitoneally with Aspergillus fumigatus (Af) extract emulsified with aluminum on day 0 and 7 and intranasally challenged with Af extracts on day 14 and 15. Resveratrol or dexamethasone or a vehicle was injected intraperitoneally 1 h before each challenge. Mice were sacrificed for serum, bronchoalveolar lavage fluid (BALF), and lungs 24 h after the last challenge. The control group was administered with saline. BEAS-2B was used for the experiments in vitro that Af-exposed airway epithelial cells.Resveratrol and dexamethasone attenuated the airway inflammation and eosinophilia, and reduced not only the production of IL-4, IL-5, and IL-13 in the BALF and lung tissues but also the mRNA levels of lung IL-6, TNF-α, and TGF-β induced by Af challenge (P < 0.05). Furthermore, Af-induced lung endoplasmic reticulum (ER) stress-related proteins PERK, CHOP, and GRP78 and the apoptosis markers including cleaved caspase-3 and cleaved caspase-7 were both suppressed significantly by resveratrol (P < 0.05). In vitro, activation of ER stress and the Akt/mTOR pathway in Af-exposed BEAS-2B cells were effectively ameliorated by resveratrol. Inhibition of the Akt/mTOR pathway using LY294002 suppressed the ER stress while ER stress inhibitor 4-PBA decreased the apoptosis in Af-exposed BEAS-2B cells.Our findings collectively revealed that resveratrol alleviated the Af-exposed allergic inflammation and apoptosis through inhibiting ER stress via Akt/mTOR pathway, exerting therapeutic effects on the fungus-induced allergic lung disorder." @default.
• W4200461195 created "2021-12-31" @default.
• W4200461195 creator A5006475724 @default.
• W4200461195 creator A5014105209 @default.
• W4200461195 creator A5023224774 @default.
• W4200461195 creator A5032018308 @default.
• W4200461195 creator A5040934834 @default.
• W4200461195 creator A5071672663 @default.
• W4200461195 creator A5078217728 @default.
• W4200461195 date "2022-02-01" @default.
• W4200461195 modified "2023-10-13" @default.
• W4200461195 title "Resveratrol attenuates inflammation and apoptosis through alleviating endoplasmic reticulum stress via Akt/mTOR pathway in fungus-induced allergic airways inflammation" @default.
• W4200461195 cites W1928868997 @default.
• W4200461195 cites W2042580565 @default.
• W4200461195 cites W2055869503 @default.
• W4200461195 cites W2096308348 @default.
• W4200461195 cites W2098248531 @default.
• W4200461195 cites W2103871132 @default.
• W4200461195 cites W2125121177 @default.
• W4200461195 cites W2132275674 @default.
• W4200461195 cites W2139627695 @default.
• W4200461195 cites W2162074188 @default.
• W4200461195 cites W2170607740 @default.
• W4200461195 cites W2209714275 @default.
• W4200461195 cites W2347117824 @default.
• W4200461195 cites W2526892675 @default.
• W4200461195 cites W2533000987 @default.
• W4200461195 cites W2568995659 @default.
• W4200461195 cites W2616166487 @default.
• W4200461195 cites W2616881825 @default.
• W4200461195 cites W2748221290 @default.
• W4200461195 cites W2765090935 @default.
• W4200461195 cites W2771823836 @default.
• W4200461195 cites W2787482595 @default.
• W4200461195 cites W2891824977 @default.
• W4200461195 cites W2897610004 @default.
• W4200461195 cites W2939247829 @default.
• W4200461195 cites W2969700754 @default.
• W4200461195 cites W2981669883 @default.
• W4200461195 cites W2993873342 @default.
• W4200461195 cites W3035742874 @default.
• W4200461195 cites W3047171548 @default.
• W4200461195 cites W3086085822 @default.
• W4200461195 cites W3092972404 @default.
• W4200461195 cites W3134107866 @default.
• W4200461195 doi "https://doi.org/10.1016/j.intimp.2021.108489" @default.
• W4200461195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34968999" @default.
• W4200461195 hasPublicationYear "2022" @default.
• W4200461195 type Work @default.
• W4200461195 citedByCount "6" @default.
• W4200461195 countsByYear W42004611952022 @default.
• W4200461195 countsByYear W42004611952023 @default.
• W4200461195 crossrefType "journal-article" @default.
• W4200461195 hasAuthorship W4200461195A5006475724 @default.
• W4200461195 hasAuthorship W4200461195A5014105209 @default.
• W4200461195 hasAuthorship W4200461195A5023224774 @default.
• W4200461195 hasAuthorship W4200461195A5032018308 @default.
• W4200461195 hasAuthorship W4200461195A5040934834 @default.
• W4200461195 hasAuthorship W4200461195A5071672663 @default.
• W4200461195 hasAuthorship W4200461195A5078217728 @default.
• W4200461195 hasConcept C126322002 @default.
• W4200461195 hasConcept C134018914 @default.
• W4200461195 hasConcept C139447449 @default.
• W4200461195 hasConcept C158617107 @default.
• W4200461195 hasConcept C185592680 @default.
• W4200461195 hasConcept C190283241 @default.
• W4200461195 hasConcept C203014093 @default.
• W4200461195 hasConcept C2776151105 @default.
• W4200461195 hasConcept C2776816829 @default.
• W4200461195 hasConcept C2776914184 @default.
• W4200461195 hasConcept C2776946954 @default.
• W4200461195 hasConcept C2777714996 @default.
• W4200461195 hasConcept C2777961210 @default.
• W4200461195 hasConcept C2780401358 @default.
• W4200461195 hasConcept C55493867 @default.
• W4200461195 hasConcept C71924100 @default.
• W4200461195 hasConcept C75217442 @default.
• W4200461195 hasConcept C86554907 @default.
• W4200461195 hasConcept C8891405 @default.
• W4200461195 hasConcept C98274493 @default.
• W4200461195 hasConceptScore W4200461195C126322002 @default.
• W4200461195 hasConceptScore W4200461195C134018914 @default.
• W4200461195 hasConceptScore W4200461195C139447449 @default.
• W4200461195 hasConceptScore W4200461195C158617107 @default.
• W4200461195 hasConceptScore W4200461195C185592680 @default.
• W4200461195 hasConceptScore W4200461195C190283241 @default.
• W4200461195 hasConceptScore W4200461195C203014093 @default.
• W4200461195 hasConceptScore W4200461195C2776151105 @default.
• W4200461195 hasConceptScore W4200461195C2776816829 @default.
• W4200461195 hasConceptScore W4200461195C2776914184 @default.
• W4200461195 hasConceptScore W4200461195C2776946954 @default.
• W4200461195 hasConceptScore W4200461195C2777714996 @default.
• W4200461195 hasConceptScore W4200461195C2777961210 @default.
• W4200461195 hasConceptScore W4200461195C2780401358 @default.
• W4200461195 hasConceptScore W4200461195C55493867 @default.
• W4200461195 hasConceptScore W4200461195C71924100 @default.
• W4200461195 hasConceptScore W4200461195C75217442 @default.
• W4200461195 hasConceptScore W4200461195C86554907 @default.

• next