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- W4200462005 abstract "Alzheimer’s disease is a progressive neurodegenerative disorder affecting around 30 million patients worldwide. The predominant sporadic variant remains enigmatic as the underlying cause has still not been identified. Since efficient therapeutic treatments are still lacking, the microbiome and its manipulation have been considered as a new, innovative approach. 5xFAD Alzheimer’s disease model mice were subjected to one-time fecal material transfer after antibiotics-treatment using two types of inoculation: material derived from the caecum of age-matched (young) wild type mice or from middle aged, 1 year old (old) wild type mice. Mice were profiled after transfer for physiological parameters, microbiome, behavioral tasks, and amyloid deposition. A single time transfer of cecal material from the older donor group established an aged phenotype in the recipient animals as indicated by elevated cultivatable fecal Enterobacteriaceae and Lactobacillaceae representative bacteria, a decreased Firmicutes amount as assessed by qPCR, and by increased levels of serum LPS binding protein. While behavioral deficits were not accelerated, single brain regions (prefrontal cortex and dentate gyrus) showed higher plaque load after transfer of material from older animals. We could demonstrate that the age of the donor of cecal material might affect early pathological hallmarks of Alzheimer’s disease. This could be relevant when considering new microbiome-based therapies for this devastating disorder." @default.
- W4200462005 created "2021-12-31" @default.
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- W4200462005 date "2021-12-09" @default.
- W4200462005 modified "2023-09-26" @default.
- W4200462005 title "Impact of the Age of Cecal Material Transfer Donors on Alzheimer’s Disease Pathology in 5xFAD Mice" @default.
- W4200462005 cites W1785160854 @default.
- W4200462005 cites W1965930828 @default.
- W4200462005 cites W1967630676 @default.
- W4200462005 cites W1968551454 @default.
- W4200462005 cites W1970720793 @default.
- W4200462005 cites W1987809028 @default.
- W4200462005 cites W1990078328 @default.
- W4200462005 cites W1993571512 @default.
- W4200462005 cites W1995359262 @default.
- W4200462005 cites W1996191997 @default.
- W4200462005 cites W2002883084 @default.
- W4200462005 cites W2005258869 @default.
- W4200462005 cites W2010795621 @default.
- W4200462005 cites W2012279592 @default.
- W4200462005 cites W2015199723 @default.
- W4200462005 cites W2016044476 @default.
- W4200462005 cites W2019297242 @default.
- W4200462005 cites W2019428673 @default.
- W4200462005 cites W2026538105 @default.
- W4200462005 cites W2028731862 @default.
- W4200462005 cites W2030774611 @default.
- W4200462005 cites W2033345409 @default.
- W4200462005 cites W2034677420 @default.
- W4200462005 cites W2043335534 @default.
- W4200462005 cites W2045577016 @default.
- W4200462005 cites W2054543134 @default.
- W4200462005 cites W2064836594 @default.
- W4200462005 cites W2093346747 @default.
- W4200462005 cites W2093797646 @default.
- W4200462005 cites W2097808005 @default.
- W4200462005 cites W2101970362 @default.
- W4200462005 cites W2104037158 @default.
- W4200462005 cites W2106336538 @default.
- W4200462005 cites W2106990053 @default.
- W4200462005 cites W2127002737 @default.
- W4200462005 cites W2133519060 @default.
- W4200462005 cites W2142536690 @default.
- W4200462005 cites W2144079797 @default.
- W4200462005 cites W2151502463 @default.
- W4200462005 cites W2159851116 @default.
- W4200462005 cites W2163566242 @default.
- W4200462005 cites W2170644095 @default.
- W4200462005 cites W217216353 @default.
- W4200462005 cites W2189523996 @default.
- W4200462005 cites W2285618695 @default.
- W4200462005 cites W2327790265 @default.
- W4200462005 cites W2341006644 @default.
- W4200462005 cites W2401857311 @default.
- W4200462005 cites W2479642761 @default.
- W4200462005 cites W2508213551 @default.
- W4200462005 cites W2508939482 @default.
- W4200462005 cites W2521033443 @default.
- W4200462005 cites W2566271081 @default.
- W4200462005 cites W2587539025 @default.
- W4200462005 cites W2596902967 @default.
- W4200462005 cites W2607434574 @default.
- W4200462005 cites W2615460620 @default.
- W4200462005 cites W2695618445 @default.
- W4200462005 cites W2735259022 @default.
- W4200462005 cites W2750838281 @default.
- W4200462005 cites W2753802402 @default.
- W4200462005 cites W2761210275 @default.
- W4200462005 cites W2767190196 @default.
- W4200462005 cites W2770969221 @default.
- W4200462005 cites W2783453358 @default.
- W4200462005 cites W2801801043 @default.
- W4200462005 cites W2801921383 @default.
- W4200462005 cites W2804002517 @default.
- W4200462005 cites W2805633350 @default.
- W4200462005 cites W2807828439 @default.
- W4200462005 cites W2884737885 @default.
- W4200462005 cites W2890995777 @default.
- W4200462005 cites W2899391538 @default.
- W4200462005 cites W2907243563 @default.
- W4200462005 cites W2908750541 @default.
- W4200462005 cites W2925274661 @default.
- W4200462005 cites W2954935271 @default.
- W4200462005 cites W2964346365 @default.
- W4200462005 cites W2965398438 @default.
- W4200462005 cites W2970199590 @default.
- W4200462005 cites W2970936061 @default.
- W4200462005 cites W2980443155 @default.
- W4200462005 cites W2986577774 @default.
- W4200462005 cites W3008162495 @default.
- W4200462005 cites W3013060838 @default.
- W4200462005 cites W3023658275 @default.
- W4200462005 cites W3024596659 @default.