Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200464422> ?p ?o ?g. }
- W4200464422 abstract "Summary Transcriptional bursting has been linked to the stochastic positioning of nucleosomes. However, how bursting is regulated by remodeling of promoter nucleosomes is unknown. Here, we use single-molecule live-cell imaging of GAL10 transcription in budding yeast to measure how transcriptional bursting changes upon single and double perturbations of chromatin remodeling factors, the transcription factor Gal4 and preinitiation complex (PIC) components. Using dynamic epistasis analysis, we reveal how remodeling of different nucleosomes regulates individual transcriptional bursting parameters. At the nucleosome covering the Gal4 binding sites, RSC acts synergistically with Gal4 binding to facilitate each burst. Conversely, nucleosome remodeling at the TATA box controls only the first burst upon galactose induction. In the absence of remodelers, nucleosomes at canonical TATA boxes are displaced by TBP binding to allow for transcription activation. Overall, our results reveal how promoter nucleosome remodeling, together with transcription factor and PIC binding regulates the kinetics of transcriptional bursting." @default.
- W4200464422 created "2021-12-31" @default.
- W4200464422 creator A5033153166 @default.
- W4200464422 creator A5066332148 @default.
- W4200464422 creator A5066566000 @default.
- W4200464422 creator A5080020012 @default.
- W4200464422 date "2021-12-15" @default.
- W4200464422 modified "2023-10-02" @default.
- W4200464422 title "Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting" @default.
- W4200464422 cites W1966361889 @default.
- W4200464422 cites W1974595249 @default.
- W4200464422 cites W1987900665 @default.
- W4200464422 cites W2017886758 @default.
- W4200464422 cites W2020541351 @default.
- W4200464422 cites W2029214081 @default.
- W4200464422 cites W2053161221 @default.
- W4200464422 cites W2054147565 @default.
- W4200464422 cites W2097096882 @default.
- W4200464422 cites W2098745106 @default.
- W4200464422 cites W2102221598 @default.
- W4200464422 cites W2102499347 @default.
- W4200464422 cites W2105522597 @default.
- W4200464422 cites W2115998813 @default.
- W4200464422 cites W2125039755 @default.
- W4200464422 cites W2127013070 @default.
- W4200464422 cites W2136257210 @default.
- W4200464422 cites W2137753785 @default.
- W4200464422 cites W2140162352 @default.
- W4200464422 cites W2148078988 @default.
- W4200464422 cites W2151294425 @default.
- W4200464422 cites W2154963196 @default.
- W4200464422 cites W2155277330 @default.
- W4200464422 cites W2162598202 @default.
- W4200464422 cites W2163189084 @default.
- W4200464422 cites W2167840211 @default.
- W4200464422 cites W2170551349 @default.
- W4200464422 cites W2171327609 @default.
- W4200464422 cites W2171432823 @default.
- W4200464422 cites W2288271511 @default.
- W4200464422 cites W2411956266 @default.
- W4200464422 cites W2520113997 @default.
- W4200464422 cites W2562186464 @default.
- W4200464422 cites W2623255489 @default.
- W4200464422 cites W2742732223 @default.
- W4200464422 cites W2804628600 @default.
- W4200464422 cites W2831181062 @default.
- W4200464422 cites W2889139968 @default.
- W4200464422 cites W2896658465 @default.
- W4200464422 cites W2896975129 @default.
- W4200464422 cites W2904555596 @default.
- W4200464422 cites W2904827199 @default.
- W4200464422 cites W2907318477 @default.
- W4200464422 cites W2911100033 @default.
- W4200464422 cites W2950346133 @default.
- W4200464422 cites W2950681580 @default.
- W4200464422 cites W2951091094 @default.
- W4200464422 cites W2966463765 @default.
- W4200464422 cites W2990228889 @default.
- W4200464422 cites W3000377151 @default.
- W4200464422 cites W3002383894 @default.
- W4200464422 cites W3005287223 @default.
- W4200464422 cites W3092923348 @default.
- W4200464422 cites W3121036262 @default.
- W4200464422 cites W3121168794 @default.
- W4200464422 cites W3178634072 @default.
- W4200464422 cites W3183548352 @default.
- W4200464422 cites W3189598002 @default.
- W4200464422 doi "https://doi.org/10.1101/2021.12.15.472793" @default.
- W4200464422 hasPublicationYear "2021" @default.
- W4200464422 type Work @default.
- W4200464422 citedByCount "1" @default.
- W4200464422 countsByYear W42004644222023 @default.
- W4200464422 crossrefType "posted-content" @default.
- W4200464422 hasAuthorship W4200464422A5033153166 @default.
- W4200464422 hasAuthorship W4200464422A5066332148 @default.
- W4200464422 hasAuthorship W4200464422A5066566000 @default.
- W4200464422 hasAuthorship W4200464422A5080020012 @default.
- W4200464422 hasBestOaLocation W42004644221 @default.
- W4200464422 hasConcept C104317684 @default.
- W4200464422 hasConcept C138885662 @default.
- W4200464422 hasConcept C167227067 @default.
- W4200464422 hasConcept C169760540 @default.
- W4200464422 hasConcept C179926584 @default.
- W4200464422 hasConcept C195221683 @default.
- W4200464422 hasConcept C27153228 @default.
- W4200464422 hasConcept C41895202 @default.
- W4200464422 hasConcept C54355233 @default.
- W4200464422 hasConcept C83640560 @default.
- W4200464422 hasConcept C84772758 @default.
- W4200464422 hasConcept C86339819 @default.
- W4200464422 hasConcept C86803240 @default.
- W4200464422 hasConcept C95444343 @default.
- W4200464422 hasConceptScore W4200464422C104317684 @default.
- W4200464422 hasConceptScore W4200464422C138885662 @default.
- W4200464422 hasConceptScore W4200464422C167227067 @default.
- W4200464422 hasConceptScore W4200464422C169760540 @default.
- W4200464422 hasConceptScore W4200464422C179926584 @default.
- W4200464422 hasConceptScore W4200464422C195221683 @default.
- W4200464422 hasConceptScore W4200464422C27153228 @default.
- W4200464422 hasConceptScore W4200464422C41895202 @default.