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- W4200466900 abstract "Gellan gum is an anionic, water-soluble, and exo–tetra-polysaccharide. Its noble properties like thermal stability, biocompatibility, nontoxicity, high transparency, acceptable taste, and excellent gelling ability convinced its approval as a natural food additive by food and drug regulatory authorities. It is pragmatic in the pharmaceutical and food industry as a stabilizing, thickening, emulsifying, binding, and gelling agent. Pharmaceutical grounds apply gellan gum and its composites in the formulation of floating/matrix tablets, hydrogels, microspheres, and nanodrug delivery. The double helical structure during cold, the random coiled structure while hot, and the formation of gels in the presence of cations promoting the aggregation site by binding between pairs of carboxylate groups on neighboring helixes make the gellan gum an exceptional candidate in the drug delivery applications. The composites formed by using natural and synthetic polymers like gelatin, polyvinyl alcohol, chitosan, etc. have added additional benefits to the properties of gellan gum, viz. enhanced mechanical properties and decreased degradation rates. For example, gellan gum hydrogel is less pH dependent in contrast to other polysaccharide hydrogels. The stability or mechanical properties are improved by the chemical modification with photosensitive groups such as methacrylates. Based on these exceptional physiognomies, gellan gum is proposed for numerous solicitations in the field of controlled drug delivery system, especially in nanomedicine. Hence, this chapter addresses the conduits and updates of the gellan gum-based nanodrug delivery system." @default.
- W4200466900 created "2021-12-31" @default.
- W4200466900 creator A5023095637 @default.
- W4200466900 creator A5031849740 @default.
- W4200466900 creator A5045387241 @default.
- W4200466900 creator A5053157724 @default.
- W4200466900 date "2021-12-10" @default.
- W4200466900 modified "2023-10-17" @default.
- W4200466900 title "Biopolymer‐Based Scaffolds for Bone and Tissue Engineering" @default.
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