Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200468018> ?p ?o ?g. }
- W4200468018 abstract "Fungal infections impact over 25% of the global population. For the opportunistic fungal pathogen, Cryptococcus neoformans, infection leads to cryptococcosis. In the presence of the host, disease is enabled by elaboration of sophisticated virulence determinants, including polysaccharide capsule, melanin, thermotolerance, and extracellular enzymes. Conversely, the host protects itself from fungal invasion by regulating and sequestering transition metals (e.g., iron, zinc, copper) important for microbial growth and survival.Here, we explore the intricate relationship between zinc availability and fungal virulence via mass spectrometry-based quantitative proteomics. We observe a core proteome along with a distinct zinc-regulated protein-level signature demonstrating a shift away from transport and ion binding under zinc-replete conditions towards transcription and metal acquisition under zinc-limited conditions. In addition, we revealed a novel connection among zinc availability, thermotolerance, as well as capsule and melanin production through the detection of a Wos2 ortholog in the secretome under replete conditions.Overall, we provide new biological insight into cellular remodeling at the protein level of C. neoformans under regulated zinc conditions and uncover a novel connection between zinc homeostasis and fungal virulence determinants." @default.
- W4200468018 created "2021-12-31" @default.
- W4200468018 creator A5007442171 @default.
- W4200468018 creator A5011110554 @default.
- W4200468018 creator A5020482224 @default.
- W4200468018 creator A5024952937 @default.
- W4200468018 creator A5026472200 @default.
- W4200468018 creator A5027363001 @default.
- W4200468018 creator A5031154781 @default.
- W4200468018 creator A5041464594 @default.
- W4200468018 creator A5051103883 @default.
- W4200468018 creator A5068625922 @default.
- W4200468018 creator A5072224048 @default.
- W4200468018 creator A5080182722 @default.
- W4200468018 creator A5090295118 @default.
- W4200468018 date "2021-12-13" @default.
- W4200468018 modified "2023-10-10" @default.
- W4200468018 title "Proteome and secretome profiling of zinc availability in Cryptococcus neoformans identifies Wos2 as a subtle influencer of fungal virulence determinants" @default.
- W4200468018 cites W1427182169 @default.
- W4200468018 cites W1882262859 @default.
- W4200468018 cites W1941267787 @default.
- W4200468018 cites W1964339096 @default.
- W4200468018 cites W1972120846 @default.
- W4200468018 cites W1978958732 @default.
- W4200468018 cites W1981341936 @default.
- W4200468018 cites W1983882206 @default.
- W4200468018 cites W1986656413 @default.
- W4200468018 cites W1991330646 @default.
- W4200468018 cites W2002155770 @default.
- W4200468018 cites W2025868705 @default.
- W4200468018 cites W2036321220 @default.
- W4200468018 cites W2038931212 @default.
- W4200468018 cites W2039859631 @default.
- W4200468018 cites W2046164813 @default.
- W4200468018 cites W2047880857 @default.
- W4200468018 cites W2051765741 @default.
- W4200468018 cites W2056573634 @default.
- W4200468018 cites W2060976020 @default.
- W4200468018 cites W2062406170 @default.
- W4200468018 cites W2070085194 @default.
- W4200468018 cites W2080752012 @default.
- W4200468018 cites W2089269684 @default.
- W4200468018 cites W2093734206 @default.
- W4200468018 cites W2095601290 @default.
- W4200468018 cites W2096375646 @default.
- W4200468018 cites W2099224272 @default.
- W4200468018 cites W2100992169 @default.
- W4200468018 cites W2105738527 @default.
- W4200468018 cites W2107794472 @default.
- W4200468018 cites W2112310296 @default.
- W4200468018 cites W2113115576 @default.
- W4200468018 cites W2114908128 @default.
- W4200468018 cites W2124091237 @default.
- W4200468018 cites W2125636530 @default.
- W4200468018 cites W2126942327 @default.
- W4200468018 cites W2128702173 @default.
- W4200468018 cites W2128880918 @default.
- W4200468018 cites W2129431352 @default.
- W4200468018 cites W2147431408 @default.
- W4200468018 cites W2157045527 @default.
- W4200468018 cites W2157127548 @default.
- W4200468018 cites W2166710421 @default.
- W4200468018 cites W2170776626 @default.
- W4200468018 cites W2343776672 @default.
- W4200468018 cites W2438964511 @default.
- W4200468018 cites W2463195069 @default.
- W4200468018 cites W2511161664 @default.
- W4200468018 cites W2589036275 @default.
- W4200468018 cites W2611697423 @default.
- W4200468018 cites W2612278270 @default.
- W4200468018 cites W2755163126 @default.
- W4200468018 cites W2765281411 @default.
- W4200468018 cites W2767031614 @default.
- W4200468018 cites W2799487950 @default.
- W4200468018 cites W2804198042 @default.
- W4200468018 cites W2883231595 @default.
- W4200468018 cites W2900569176 @default.
- W4200468018 cites W2915517175 @default.
- W4200468018 cites W2944715677 @default.
- W4200468018 cites W2945540290 @default.
- W4200468018 cites W2947221844 @default.
- W4200468018 cites W2953080604 @default.
- W4200468018 cites W2955486497 @default.
- W4200468018 cites W2990816241 @default.
- W4200468018 cites W2993763753 @default.
- W4200468018 cites W3015272365 @default.
- W4200468018 cites W3042540390 @default.
- W4200468018 cites W3044730196 @default.
- W4200468018 cites W3092448836 @default.
- W4200468018 doi "https://doi.org/10.1186/s12866-021-02410-z" @default.
- W4200468018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34903172" @default.
- W4200468018 hasPublicationYear "2021" @default.
- W4200468018 type Work @default.
- W4200468018 citedByCount "6" @default.
- W4200468018 countsByYear W42004680182021 @default.
- W4200468018 countsByYear W42004680182022 @default.
- W4200468018 countsByYear W42004680182023 @default.
- W4200468018 crossrefType "journal-article" @default.
- W4200468018 hasAuthorship W4200468018A5007442171 @default.
- W4200468018 hasAuthorship W4200468018A5011110554 @default.