FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200470242> ?p ?o ?g. }

• W4200470242 endingPage "363" @default.
• W4200470242 startingPage "363" @default.
• W4200470242 abstract "Methamphetamine (METH) is a highly abused psychostimulant that is neurotoxic to dopaminergic (DAergic) nerve terminals in the striatum and increases the risk of developing Parkinson's disease (PD). In vivo, METH-mediated DA release, followed by DA-mediated oxidative stress and mitochondrial dysfunction in pre- and postsynaptic neurons, mediates METH neurotoxicity. METH-triggered oxidative stress damages parkin, a neuroprotective protein involved in PD etiology via its involvement in the maintenance of mitochondria. It is not known whether METH itself contributes to mitochondrial dysfunction and whether parkin regulates complex I, an enzymatic complex downregulated in PD. To determine this, we separately assessed the effects of METH or DA alone on electron transport chain (ETC) complexes and the protein parkin in isolated striatal mitochondria. We show that METH decreases the levels of selected complex I, II, and III subunits (NDUFS3, SDHA, and UQCRC2, respectively), whereas DA decreases the levels only of the NDUFS3 subunit in our preparations. We also show that the selected subunits are not decreased in synaptosomal mitochondria under similar experimental conditions. Finally, we found that parkin overexpression does not influence the levels of the NDUFS3 subunit in rat striatum. The presented results indicate that METH itself is a factor promoting dysfunction of striatal mitochondria; therefore, it is a potential drug target against METH neurotoxicity. The observed decreases in ETC complex subunits suggest that DA and METH decrease activities of the ETC complexes via oxidative damage to their subunits and that synaptosomal mitochondria may be somewhat resistant to DA- and METH-induced disruption in mitochondrial ETC complexes than perikaryal mitochondria. The results also suggest that parkin does not regulate NDUFS3 turnover in rat striatum." @default.
• W4200470242 created "2021-12-31" @default.
• W4200470242 creator A5000792302 @default.
• W4200470242 creator A5003378130 @default.
• W4200470242 creator A5017767544 @default.
• W4200470242 creator A5021103203 @default.
• W4200470242 creator A5031359675 @default.
• W4200470242 date "2021-12-29" @default.
• W4200470242 modified "2023-10-11" @default.
• W4200470242 title "Dopamine and Methamphetamine Differentially Affect Electron Transport Chain Complexes and Parkin in Rat Striatum: New Insight into Methamphetamine Neurotoxicity" @default.
• W4200470242 cites W1491612122 @default.
• W4200470242 cites W150246076 @default.
• W4200470242 cites W1505565391 @default.
• W4200470242 cites W1507935478 @default.
• W4200470242 cites W1514765762 @default.
• W4200470242 cites W1530276807 @default.
• W4200470242 cites W1593555249 @default.
• W4200470242 cites W1601613466 @default.
• W4200470242 cites W1627935689 @default.
• W4200470242 cites W1783946558 @default.
• W4200470242 cites W1895466054 @default.
• W4200470242 cites W1909184393 @default.
• W4200470242 cites W1909937204 @default.
• W4200470242 cites W1926695909 @default.
• W4200470242 cites W1964741828 @default.
• W4200470242 cites W1965347832 @default.
• W4200470242 cites W1965877041 @default.
• W4200470242 cites W1967701574 @default.
• W4200470242 cites W1968031193 @default.
• W4200470242 cites W1968449546 @default.
• W4200470242 cites W1968753027 @default.
• W4200470242 cites W1972750524 @default.
• W4200470242 cites W1981705617 @default.
• W4200470242 cites W1984197213 @default.
• W4200470242 cites W1988720067 @default.
• W4200470242 cites W1991094289 @default.
• W4200470242 cites W1994177774 @default.
• W4200470242 cites W1997935297 @default.
• W4200470242 cites W1999098395 @default.
• W4200470242 cites W1999483432 @default.
• W4200470242 cites W1999766074 @default.
• W4200470242 cites W2005441809 @default.
• W4200470242 cites W2005594930 @default.
• W4200470242 cites W2005952891 @default.
• W4200470242 cites W2007550255 @default.
• W4200470242 cites W2008524165 @default.
• W4200470242 cites W2008560382 @default.
• W4200470242 cites W2008959316 @default.
• W4200470242 cites W2011124366 @default.
• W4200470242 cites W2011352058 @default.
• W4200470242 cites W2012848446 @default.
• W4200470242 cites W2016344599 @default.
• W4200470242 cites W2017621114 @default.
• W4200470242 cites W2022458326 @default.
• W4200470242 cites W2023811660 @default.
• W4200470242 cites W2025165424 @default.
• W4200470242 cites W2035503754 @default.
• W4200470242 cites W2035919788 @default.
• W4200470242 cites W2046319117 @default.
• W4200470242 cites W2046425161 @default.
• W4200470242 cites W2047730122 @default.
• W4200470242 cites W2047791683 @default.
• W4200470242 cites W2048020456 @default.
• W4200470242 cites W2048267543 @default.
• W4200470242 cites W2052630867 @default.
• W4200470242 cites W2052786394 @default.
• W4200470242 cites W2058645571 @default.
• W4200470242 cites W2061818264 @default.
• W4200470242 cites W2063302293 @default.
• W4200470242 cites W2068976528 @default.
• W4200470242 cites W2073173679 @default.
• W4200470242 cites W2076598575 @default.
• W4200470242 cites W2081595932 @default.
• W4200470242 cites W2081947637 @default.
• W4200470242 cites W2082425146 @default.
• W4200470242 cites W2083273040 @default.
• W4200470242 cites W2087693218 @default.
• W4200470242 cites W2091286093 @default.
• W4200470242 cites W2091380103 @default.
• W4200470242 cites W2092725897 @default.
• W4200470242 cites W2105754268 @default.
• W4200470242 cites W2113507118 @default.
• W4200470242 cites W2121532472 @default.
• W4200470242 cites W2131659232 @default.
• W4200470242 cites W2132084774 @default.
• W4200470242 cites W2134898475 @default.
• W4200470242 cites W2138563618 @default.
• W4200470242 cites W2139501951 @default.
• W4200470242 cites W2140337315 @default.
• W4200470242 cites W2140647923 @default.
• W4200470242 cites W2141712052 @default.
• W4200470242 cites W2142896446 @default.
• W4200470242 cites W2143005569 @default.
• W4200470242 cites W2153938792 @default.
• W4200470242 cites W2160193331 @default.
• W4200470242 cites W2164801924 @default.
• W4200470242 cites W2165834300 @default.
• W4200470242 cites W2211987820 @default.

• next