Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200470931> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4200470931 abstract "Abstract Bacteria can bypass the blood-brain barrier (BBB) transcellularly, paracellularly and/or in infected phagocytes, suggesting the possibility of employment of bacteria for combating central nervous system (CNS) diseases. However, the bacteria-based drug delivery vehicle crossing the BBB is still vacant up to present. Herein, we develop an innovative bacteria-based drug delivery system (dubbed Trojan bacteria) for glioblastoma (GBM) photothermal immunotherapy. Typically, Trojan bacteria are made of therapeutics internalized into bacteria (e.g., attenuated Salmonella typhimurium , Escherichia coli ). The therapeutics are composed of glucose polymer (GP) (e.g., poly[4-O-(α-D-glucopyranosyl)-D-glucopyranose] )-conjugated and indocyanine green (ICG)-loaded silicon nanoparticles (GP-ICG-SiNPs). The GP-ICG-SiNPs can be selectively and robustly internalized into the bacterial intracellular volume through the bacteria-specific ATP-binding cassette (ABC) transporter. In an orthotopic GBM mouse model, we demonstrate that the intravenously injected Trojan bacteria could take therapeutics together not only to bypass the BBB, but also to target and penetrate GBM tissues. Under 808 nm-laser irradiation, the photothermal effects (PTT) produced by ICG allow the destruction of Trojan bacterial cells and the adjacent tumour cells. Furthermore, the bacterial debris as well as the tumour-associated antigens would promote antitumor immune responses that prolong the survival of GBM-bearing mice. Moreover, we demonstrate the residual Trojan bacteria could be effectively eliminated from the body due to the distinct photothermal effects. We anticipate the proposed Trojan bacteria system would catalyze innovative therapies for various CNS diseases." @default.
- W4200470931 created "2021-12-31" @default.
- W4200470931 creator A5000385201 @default.
- W4200470931 creator A5002058602 @default.
- W4200470931 creator A5006119430 @default.
- W4200470931 creator A5033893564 @default.
- W4200470931 creator A5044689993 @default.
- W4200470931 creator A5047504094 @default.
- W4200470931 creator A5047591121 @default.
- W4200470931 creator A5051062987 @default.
- W4200470931 date "2021-12-10" @default.
- W4200470931 modified "2023-09-26" @default.
- W4200470931 title "Trojan bacteria cross blood-brain barrier for glioblastoma photothermal immunotherapy" @default.
- W4200470931 doi "https://doi.org/10.21203/rs.3.rs-1114519/v1" @default.
- W4200470931 hasPublicationYear "2021" @default.
- W4200470931 type Work @default.
- W4200470931 citedByCount "0" @default.
- W4200470931 crossrefType "posted-content" @default.
- W4200470931 hasAuthorship W4200470931A5000385201 @default.
- W4200470931 hasAuthorship W4200470931A5002058602 @default.
- W4200470931 hasAuthorship W4200470931A5006119430 @default.
- W4200470931 hasAuthorship W4200470931A5033893564 @default.
- W4200470931 hasAuthorship W4200470931A5044689993 @default.
- W4200470931 hasAuthorship W4200470931A5047504094 @default.
- W4200470931 hasAuthorship W4200470931A5047591121 @default.
- W4200470931 hasAuthorship W4200470931A5051062987 @default.
- W4200470931 hasBestOaLocation W42004709311 @default.
- W4200470931 hasConcept C169760540 @default.
- W4200470931 hasConcept C171250308 @default.
- W4200470931 hasConcept C174333608 @default.
- W4200470931 hasConcept C178790620 @default.
- W4200470931 hasConcept C182606246 @default.
- W4200470931 hasConcept C185592680 @default.
- W4200470931 hasConcept C192562407 @default.
- W4200470931 hasConcept C203014093 @default.
- W4200470931 hasConcept C2777701055 @default.
- W4200470931 hasConcept C2778227246 @default.
- W4200470931 hasConcept C2778402981 @default.
- W4200470931 hasConcept C2779820397 @default.
- W4200470931 hasConcept C38652104 @default.
- W4200470931 hasConcept C41008148 @default.
- W4200470931 hasConcept C502942594 @default.
- W4200470931 hasConcept C523546767 @default.
- W4200470931 hasConcept C529278444 @default.
- W4200470931 hasConcept C54355233 @default.
- W4200470931 hasConcept C86803240 @default.
- W4200470931 hasConcept C8891405 @default.
- W4200470931 hasConcept C89423630 @default.
- W4200470931 hasConceptScore W4200470931C169760540 @default.
- W4200470931 hasConceptScore W4200470931C171250308 @default.
- W4200470931 hasConceptScore W4200470931C174333608 @default.
- W4200470931 hasConceptScore W4200470931C178790620 @default.
- W4200470931 hasConceptScore W4200470931C182606246 @default.
- W4200470931 hasConceptScore W4200470931C185592680 @default.
- W4200470931 hasConceptScore W4200470931C192562407 @default.
- W4200470931 hasConceptScore W4200470931C203014093 @default.
- W4200470931 hasConceptScore W4200470931C2777701055 @default.
- W4200470931 hasConceptScore W4200470931C2778227246 @default.
- W4200470931 hasConceptScore W4200470931C2778402981 @default.
- W4200470931 hasConceptScore W4200470931C2779820397 @default.
- W4200470931 hasConceptScore W4200470931C38652104 @default.
- W4200470931 hasConceptScore W4200470931C41008148 @default.
- W4200470931 hasConceptScore W4200470931C502942594 @default.
- W4200470931 hasConceptScore W4200470931C523546767 @default.
- W4200470931 hasConceptScore W4200470931C529278444 @default.
- W4200470931 hasConceptScore W4200470931C54355233 @default.
- W4200470931 hasConceptScore W4200470931C86803240 @default.
- W4200470931 hasConceptScore W4200470931C8891405 @default.
- W4200470931 hasConceptScore W4200470931C89423630 @default.
- W4200470931 hasLocation W42004709311 @default.
- W4200470931 hasOpenAccess W4200470931 @default.
- W4200470931 hasPrimaryLocation W42004709311 @default.
- W4200470931 hasRelatedWork W2073541380 @default.
- W4200470931 hasRelatedWork W3030414481 @default.
- W4200470931 hasRelatedWork W3168722526 @default.
- W4200470931 hasRelatedWork W3177607563 @default.
- W4200470931 hasRelatedWork W3178384268 @default.
- W4200470931 hasRelatedWork W4210825082 @default.
- W4200470931 hasRelatedWork W4210855089 @default.
- W4200470931 hasRelatedWork W4225273109 @default.
- W4200470931 hasRelatedWork W4285804056 @default.
- W4200470931 hasRelatedWork W50954628 @default.
- W4200470931 isParatext "false" @default.
- W4200470931 isRetracted "false" @default.
- W4200470931 workType "article" @default.