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- W4200472895 abstract "Background Ki‐67 proliferation index (PI) is important for providing information on tumor behavior, treatment response, and prognosis. Integrated positron emission tomography/magnetic resonance (PET/MR) may have the potential to assess Ki‐67 PI in patients with lung adenocarcinoma. Purpose To explore the value of simultaneous 18 F‐fluorodeoxyglucose ( 18 F‐FDG) PET/MR‐derived parameters in assessing the proliferation status of lung adenocarcinoma and to determine the best combination of parameters. Study Type Prospective. Population Seventy‐eight patients with lung adenocarcinoma and with Ki‐67 PI. Field Strength/Sequence 3. 0 T , simultaneous PET / MRI including diffusion‐weighted imaging ( DWI ) and 18 F‐FDG PET . Assessment DWI‐derived parameters, namely, apparent diffusion coefficient (ADC), true diffusion coefficient ( D ), pseudo diffusion coefficient ( D *), perfusion fraction ( f ), diffusion heterogeneity index ( α ), and distributed diffusion coefficient (DDC); and PET‐derived parameters, namely, maximum standardized uptake value (SUV max ), metabolic tumor volume (MTV), and total lesion glycolytic volume (TLG), were calculated and compared between the high (>25%) and low (≤25%) Ki‐67 PI groups. The correlations between PET‐derived parameters and DWI‐derived parameters were analyzed. Statistical Tests Student's t ‐test, Mann–Whitney U test, chi‐square test, and receiver operating characteristic (ROC) curves. A P ‐value <0.05 was considered statistically significant. Results The SUV max , MTV, TLG, ADC, D , and DDC values were significantly different between the high ( N = 35) and low Ki‐67 PI groups ( N = 43). D , SUV max , and MTV independently predicted the Ki‐67 PI status. The combination of D , SUV max , and MTV had the largest area under the ROC curve (AUC = 0.900), which was significantly larger than the AUC alone of DDC (AUC = 0.725), SUV max (AUC = 0.815), MTV (AUC = 0.774), or TLG (AUC = 0.783). The perfusion fraction did not correlate with SUV max , MTV, or TLG ( r = −0.03, −0.11, and −0.04, respectively; P = 0.786, 0.348, and 0.733). Data Conclusion The combination of D , SUV max , and MTV may predict Ki‐67 PI status. No correlation was observed between perfusion parameters and metabolic parameters. Level of Evidence 1 Technical Efficacy Stage 2" @default.
- W4200472895 created "2021-12-31" @default.
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- W4200472895 date "2021-12-10" @default.
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- W4200472895 title "Application of Simultaneous <scp><sup>18</sup>F‐FDG PET</scp> With Monoexponential, Biexponential, and Stretched Exponential Model‐Based Diffusion‐Weighted <scp>MR</scp> Imaging in Assessing the Proliferation Status of Lung Adenocarcinoma" @default.
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- W4200472895 doi "https://doi.org/10.1002/jmri.28010" @default.
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