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- W4200474967 endingPage "13634" @default.
- W4200474967 startingPage "13634" @default.
- W4200474967 abstract "Hyperactivity of the immune system in the gastrointestinal tract leads to the development of chronic, inflammation-associated disorders. Such diseases, including inflammatory bowel disease, are not completely curable, but the specific line of treatment may reduce its symptoms. However, the response to treatment varies among patients, creating a necessity to uncover the pathophysiological basis of immune-mediated diseases and apply novel therapeutic strategies. The present study describes the anti-inflammatory properties of osthole during histamine-induced inflammation in the intestinal Caco-2 cell line. Osthole reduced the secretion of cytokines (CKs) and the expression level of inflammation-associated genes, which were increased after a histamine treatment. We have shown that the secretion of pro-inflammatory CKs (IL-1β, IL-6, IL-8, and TNF-α) during inflammation may be mediated by NFκB, and, after osthole treatment, this signaling pathway was disrupted. Our results suggest a possible role for osthole in the protection against inflammation in the gastrointestinal tract; thus, osthole may be considered as an anti-inflammatory modulator." @default.
- W4200474967 created "2021-12-31" @default.
- W4200474967 creator A5021086331 @default.
- W4200474967 creator A5028569410 @default.
- W4200474967 creator A5061311979 @default.
- W4200474967 creator A5067320780 @default.
- W4200474967 date "2021-12-20" @default.
- W4200474967 modified "2023-09-30" @default.
- W4200474967 title "Effects of Osthole on Inflammatory Gene Expression and Cytokine Secretion in Histamine-Induced Inflammation in the Caco-2 Cell Line" @default.
- W4200474967 cites W1258881425 @default.
- W4200474967 cites W1522773084 @default.
- W4200474967 cites W1591275796 @default.
- W4200474967 cites W1904678284 @default.
- W4200474967 cites W1938311064 @default.
- W4200474967 cites W1967253944 @default.
- W4200474967 cites W1971605286 @default.
- W4200474967 cites W1975007185 @default.
- W4200474967 cites W1980421164 @default.
- W4200474967 cites W1982036700 @default.
- W4200474967 cites W1982162410 @default.
- W4200474967 cites W1999325378 @default.
- W4200474967 cites W2002628549 @default.
- W4200474967 cites W2032786826 @default.
- W4200474967 cites W2038168052 @default.
- W4200474967 cites W2041454039 @default.
- W4200474967 cites W2046531794 @default.
- W4200474967 cites W2048368285 @default.
- W4200474967 cites W2055991864 @default.
- W4200474967 cites W2060373663 @default.
- W4200474967 cites W2071627259 @default.
- W4200474967 cites W2073601877 @default.
- W4200474967 cites W2088647063 @default.
- W4200474967 cites W2099803817 @default.
- W4200474967 cites W2108244474 @default.
- W4200474967 cites W2117052144 @default.
- W4200474967 cites W2127533867 @default.
- W4200474967 cites W2129242841 @default.
- W4200474967 cites W2131965272 @default.
- W4200474967 cites W2143587288 @default.
- W4200474967 cites W2149089744 @default.
- W4200474967 cites W2149122802 @default.
- W4200474967 cites W2152241963 @default.
- W4200474967 cites W2165907987 @default.
- W4200474967 cites W2179166498 @default.
- W4200474967 cites W2314874096 @default.
- W4200474967 cites W2317604451 @default.
- W4200474967 cites W2343783837 @default.
- W4200474967 cites W2396765489 @default.
- W4200474967 cites W2431987552 @default.
- W4200474967 cites W2538543301 @default.
- W4200474967 cites W2550707851 @default.
- W4200474967 cites W269537389 @default.
- W4200474967 cites W2785786024 @default.
- W4200474967 cites W2794851013 @default.
- W4200474967 cites W2809589307 @default.
- W4200474967 cites W2883166145 @default.
- W4200474967 cites W2907164510 @default.
- W4200474967 cites W2909059427 @default.
- W4200474967 cites W2915204262 @default.
- W4200474967 cites W2927718321 @default.
- W4200474967 cites W2930875443 @default.
- W4200474967 cites W2972957576 @default.
- W4200474967 cites W2982061867 @default.
- W4200474967 cites W3007908201 @default.
- W4200474967 cites W3036226369 @default.
- W4200474967 cites W3045062371 @default.
- W4200474967 cites W3081902840 @default.
- W4200474967 cites W3089255592 @default.
- W4200474967 cites W3091947140 @default.
- W4200474967 cites W3094728365 @default.
- W4200474967 cites W3096777956 @default.
- W4200474967 cites W3101453601 @default.
- W4200474967 cites W3105342217 @default.
- W4200474967 cites W3114884868 @default.
- W4200474967 cites W3121625136 @default.
- W4200474967 cites W3123071086 @default.
- W4200474967 cites W3124674374 @default.
- W4200474967 cites W313982879 @default.
- W4200474967 cites W3141974255 @default.
- W4200474967 cites W3158715409 @default.
- W4200474967 cites W3168469168 @default.
- W4200474967 cites W3187682326 @default.
- W4200474967 cites W3192315369 @default.
- W4200474967 cites W3195022138 @default.
- W4200474967 cites W3202549526 @default.
- W4200474967 cites W3203003754 @default.
- W4200474967 cites W3206231699 @default.
- W4200474967 cites W3211280960 @default.
- W4200474967 cites W4205389315 @default.
- W4200474967 cites W4211217520 @default.
- W4200474967 cites W4240753609 @default.
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- W4200474967 doi "https://doi.org/10.3390/ijms222413634" @default.
- W4200474967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34948440" @default.
- W4200474967 hasPublicationYear "2021" @default.
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