Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200475077> ?p ?o ?g. }
- W4200475077 endingPage "103014" @default.
- W4200475077 startingPage "103014" @default.
- W4200475077 abstract "Chronic kidney disease (CKD) is an increasing cause of morbidity and mortality worldwide. Besides the higher prevalence of diabetes, hypertension and aging worldwide, immune mediated disorders remain an important cause of kidney disease and are especially prevalent in young adults. Regardless of the initial insult, final pathway to CKD and kidney failure is always the loss of normal tissue and fibrosis development, in which the dynamic equilibrium between extracellular matrix synthesis and degradation is disturbed, leading to excessive production and accumulation. During fibrosis, a multitude of cell types intervene at different levels, but myofibroblasts and inflammatory cells are considered critical in the process. They exert their effects through different molecular pathways, of which transforming growth factor β (TGF-β) has demonstrated to be of particular importance. Additionally, CKD itself promotes fibrosis due to the accumulation of toxins and hormonal changes, and proteinuria is simultaneously a manifestation of CKD and a specific driver of renal fibrosis. Pathways involved in renal fibrosis and CKD are closely interrelated, and although important advances have been made in our knowledge of them, it is still necessary to translate them into clinical practice. Given the complexity of this process, it is highly likely that its treatment will require a multi-target strategy to control the origin of the damage but also the mechanisms that perpetuate it. Fortunately, rapid technology development over the last years and new available drugs in the nephrologist's armamentarium give reasons for optimism that more personalized assistance for CKD and renal fibrosis will appear in the future." @default.
- W4200475077 created "2021-12-31" @default.
- W4200475077 creator A5002609265 @default.
- W4200475077 creator A5025983976 @default.
- W4200475077 creator A5037201839 @default.
- W4200475077 creator A5039223320 @default.
- W4200475077 creator A5045230922 @default.
- W4200475077 creator A5054630818 @default.
- W4200475077 creator A5062944221 @default.
- W4200475077 creator A5072533061 @default.
- W4200475077 creator A5076168240 @default.
- W4200475077 date "2022-03-01" @default.
- W4200475077 modified "2023-10-07" @default.
- W4200475077 title "Assessing and counteracting fibrosis is a cornerstone of the treatment of CKD secondary to systemic and renal limited autoimmune disorders" @default.
- W4200475077 cites W1489467378 @default.
- W4200475077 cites W1512671868 @default.
- W4200475077 cites W1518095394 @default.
- W4200475077 cites W1555896011 @default.
- W4200475077 cites W1925591757 @default.
- W4200475077 cites W1965498876 @default.
- W4200475077 cites W1970024336 @default.
- W4200475077 cites W1973850434 @default.
- W4200475077 cites W1978127755 @default.
- W4200475077 cites W1978882265 @default.
- W4200475077 cites W1983083053 @default.
- W4200475077 cites W1984261234 @default.
- W4200475077 cites W1985000750 @default.
- W4200475077 cites W1987682402 @default.
- W4200475077 cites W1992118235 @default.
- W4200475077 cites W1994800928 @default.
- W4200475077 cites W1998138748 @default.
- W4200475077 cites W2002157461 @default.
- W4200475077 cites W2010121133 @default.
- W4200475077 cites W2014414419 @default.
- W4200475077 cites W2020044440 @default.
- W4200475077 cites W2020992600 @default.
- W4200475077 cites W2021017423 @default.
- W4200475077 cites W2023191091 @default.
- W4200475077 cites W2023848963 @default.
- W4200475077 cites W2039952205 @default.
- W4200475077 cites W2043788874 @default.
- W4200475077 cites W2047270953 @default.
- W4200475077 cites W2049542629 @default.
- W4200475077 cites W2056515654 @default.
- W4200475077 cites W2056976690 @default.
- W4200475077 cites W2057217551 @default.
- W4200475077 cites W2076054800 @default.
- W4200475077 cites W2093935755 @default.
- W4200475077 cites W2097466765 @default.
- W4200475077 cites W2097550696 @default.
- W4200475077 cites W2099515182 @default.
- W4200475077 cites W2101767471 @default.
- W4200475077 cites W2104274897 @default.
- W4200475077 cites W2108986117 @default.
- W4200475077 cites W2109312341 @default.
- W4200475077 cites W2118510193 @default.
- W4200475077 cites W2122194059 @default.
- W4200475077 cites W2130229338 @default.
- W4200475077 cites W2132123065 @default.
- W4200475077 cites W2134931198 @default.
- W4200475077 cites W2136953190 @default.
- W4200475077 cites W2138991213 @default.
- W4200475077 cites W2143633302 @default.
- W4200475077 cites W2144108073 @default.
- W4200475077 cites W2146239575 @default.
- W4200475077 cites W2148400642 @default.
- W4200475077 cites W2148969684 @default.
- W4200475077 cites W2151601135 @default.
- W4200475077 cites W2153381352 @default.
- W4200475077 cites W2155504581 @default.
- W4200475077 cites W2156935689 @default.
- W4200475077 cites W2157854594 @default.
- W4200475077 cites W2163505364 @default.
- W4200475077 cites W2166890244 @default.
- W4200475077 cites W2175773897 @default.
- W4200475077 cites W2177493335 @default.
- W4200475077 cites W2189664213 @default.
- W4200475077 cites W2195718607 @default.
- W4200475077 cites W2239926509 @default.
- W4200475077 cites W2286701144 @default.
- W4200475077 cites W2295191003 @default.
- W4200475077 cites W2332128473 @default.
- W4200475077 cites W2338110434 @default.
- W4200475077 cites W2342679639 @default.
- W4200475077 cites W2347012456 @default.
- W4200475077 cites W2471813995 @default.
- W4200475077 cites W2476927394 @default.
- W4200475077 cites W2492301722 @default.
- W4200475077 cites W2519369729 @default.
- W4200475077 cites W2546645949 @default.
- W4200475077 cites W2547300331 @default.
- W4200475077 cites W2547465391 @default.
- W4200475077 cites W2552360097 @default.
- W4200475077 cites W2555239285 @default.
- W4200475077 cites W2559257586 @default.
- W4200475077 cites W2561229677 @default.
- W4200475077 cites W2567216562 @default.
- W4200475077 cites W2570430303 @default.