FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200475265> ?p ?o ?g. }

• W4200475265 endingPage "118831" @default.
• W4200475265 startingPage "118831" @default.
• W4200475265 abstract "Transmembrane water exchange is a potential biomarker in the diagnosis and understanding of cancers, brain disorders, and other diseases. Filter-exchange imaging (FEXI), a special case of diffusion exchange spectroscopy adapted for clinical applications, has the potential to reveal different physiological water exchange processes. However, it is still controversial whether modulating the diffusion encoding gradient direction can affect the apparent exchange rate (AXR) measurements of FEXI in white matter (WM) where water diffusion shows strong anisotropy. In this study, we explored the diffusion-encoding direction dependence of FEXI in human brain white matter by performing FEXI with 20 diffusion-encoding directions on a clinical 3T scanner in-vivo. The results show that the AXR values measured when the gradients are perpendicular to the fiber orientation (0.77 ± 0.13 s - 1, mean ± standard deviation of all the subjects) are significantly larger than the AXR estimates when the gradients are parallel to the fiber orientation (0.33 ± 0.14 s - 1, p < 0.001) in WM voxels with coherently-orientated fibers. In addition, no significant correlation is found between AXRs measured along these two directions, indicating that they are measuring different water exchange processes. What's more, only the perpendicular AXR rather than the parallel AXR shows dependence on axonal diameter, indicating that the perpendicular AXR might reflect transmembrane water exchange between intra-axonal and extra-cellular spaces. Further finite difference (FD) simulations having three water compartments (intra-axonal, intra-glial, and extra-cellular spaces) to mimic WM micro-environments also suggest that the perpendicular AXR is more sensitive to the axonal water transmembrane exchange than parallel AXR. Taken together, our results show that AXR measured along different directions could be utilized to probe different water exchange processes in WM." @default.
• W4200475265 created "2021-12-31" @default.
• W4200475265 creator A5018376509 @default.
• W4200475265 creator A5026251625 @default.
• W4200475265 creator A5039283857 @default.
• W4200475265 creator A5040724695 @default.
• W4200475265 creator A5054971100 @default.
• W4200475265 creator A5075009651 @default.
• W4200475265 creator A5078890425 @default.
• W4200475265 date "2022-02-01" @default.
• W4200475265 modified "2023-10-16" @default.
• W4200475265 title "The direction-dependence of apparent water exchange rate in human white matter" @default.
• W4200475265 cites W1483617892 @default.
• W4200475265 cites W1506280935 @default.
• W4200475265 cites W1570874492 @default.
• W4200475265 cites W1957911374 @default.
• W4200475265 cites W1967396591 @default.
• W4200475265 cites W1971125401 @default.
• W4200475265 cites W1992778295 @default.
• W4200475265 cites W1993399316 @default.
• W4200475265 cites W2005538210 @default.
• W4200475265 cites W2042870963 @default.
• W4200475265 cites W2046363286 @default.
• W4200475265 cites W2046529900 @default.
• W4200475265 cites W2046972731 @default.
• W4200475265 cites W2054245229 @default.
• W4200475265 cites W2062289627 @default.
• W4200475265 cites W2066807438 @default.
• W4200475265 cites W2068550627 @default.
• W4200475265 cites W2074888367 @default.
• W4200475265 cites W2082182286 @default.
• W4200475265 cites W2082825242 @default.
• W4200475265 cites W2084494338 @default.
• W4200475265 cites W2087860953 @default.
• W4200475265 cites W2089942843 @default.
• W4200475265 cites W2102520467 @default.
• W4200475265 cites W2114272337 @default.
• W4200475265 cites W2117480798 @default.
• W4200475265 cites W2128625692 @default.
• W4200475265 cites W2133612938 @default.
• W4200475265 cites W2142018683 @default.
• W4200475265 cites W2144725709 @default.
• W4200475265 cites W2148726987 @default.
• W4200475265 cites W2168667711 @default.
• W4200475265 cites W2288766392 @default.
• W4200475265 cites W2294354247 @default.
• W4200475265 cites W2337141133 @default.
• W4200475265 cites W2410473226 @default.
• W4200475265 cites W2535049226 @default.
• W4200475265 cites W2571518912 @default.
• W4200475265 cites W2605471729 @default.
• W4200475265 cites W2755595323 @default.
• W4200475265 cites W2767996512 @default.
• W4200475265 cites W2769820041 @default.
• W4200475265 cites W2790015453 @default.
• W4200475265 cites W2797728878 @default.
• W4200475265 cites W2798885694 @default.
• W4200475265 cites W2800459707 @default.
• W4200475265 cites W2809088789 @default.
• W4200475265 cites W2889674782 @default.
• W4200475265 cites W2897413527 @default.
• W4200475265 cites W2919011512 @default.
• W4200475265 cites W2919964601 @default.
• W4200475265 cites W2943617674 @default.
• W4200475265 cites W2963156163 @default.
• W4200475265 cites W3002055189 @default.
• W4200475265 cites W3035265421 @default.
• W4200475265 cites W3039068968 @default.
• W4200475265 cites W3092428922 @default.
• W4200475265 cites W329559779 @default.
• W4200475265 cites W4235770099 @default.
• W4200475265 doi "https://doi.org/10.1016/j.neuroimage.2021.118831" @default.
• W4200475265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34923129" @default.
• W4200475265 hasPublicationYear "2022" @default.
• W4200475265 type Work @default.
• W4200475265 citedByCount "3" @default.
• W4200475265 countsByYear W42004752652022 @default.
• W4200475265 countsByYear W42004752652023 @default.
• W4200475265 crossrefType "journal-article" @default.
• W4200475265 hasAuthorship W4200475265A5018376509 @default.
• W4200475265 hasAuthorship W4200475265A5026251625 @default.
• W4200475265 hasAuthorship W4200475265A5039283857 @default.
• W4200475265 hasAuthorship W4200475265A5040724695 @default.
• W4200475265 hasAuthorship W4200475265A5054971100 @default.
• W4200475265 hasAuthorship W4200475265A5075009651 @default.
• W4200475265 hasAuthorship W4200475265A5078890425 @default.
• W4200475265 hasBestOaLocation W42004752651 @default.
• W4200475265 hasConcept C120665830 @default.
• W4200475265 hasConcept C121332964 @default.
• W4200475265 hasConcept C126838900 @default.
• W4200475265 hasConcept C143409427 @default.
• W4200475265 hasConcept C149550507 @default.
• W4200475265 hasConcept C154945302 @default.
• W4200475265 hasConcept C16345878 @default.
• W4200475265 hasConcept C185592680 @default.
• W4200475265 hasConcept C199631012 @default.
• W4200475265 hasConcept C2524010 @default.
• W4200475265 hasConcept C2781192897 @default.

• next