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- W4200475644 abstract "Abstract Phototherapy-triggered immunogenic cell death (ICD) hardly elicit robust antitumor immune response partially due to low antigen exposure and inefficient antigen presentation. To address these issues, we developed a novel methylene blue loaded ovalbumin/ polypyrrole nanoparticles (MB@OVA/PPY NPs) via oxidative polymerization and π-π stacking reaction. The as-prepared MB@OVA/PPY NPs with outstanding photothermal conversion efficiency (38%) and photodynamic property could be readily internalized into cytoplasm and accumulated in lysosome and mitochondria. Upon 808 nm and 660 nm laser irradiation, the MB@OVA/PPY NPs not only ablated the tumor cells by inducing local hyperthermia, but also damaged residual tumor cells by generating a large amount of reactive oxygen species (ROS), finally triggered the release of large amount of damage associated molecular patterns (DAMPs). Moreover, the MB@OVA/PPY NPs synergized with DAMPs promoted thematuration and improved antigen presentation ability of DCs in virto and vivo. This work demonstrated that the MB@OVA/PPY NPs could be used as effective nanotherapeutic agents for eliminating the solid tumor and triggering powerful antitumor immune response." @default.
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- W4200475644 date "2021-12-22" @default.
- W4200475644 modified "2023-09-26" @default.
- W4200475644 title "Fabrication of Methylene Blue Loaded Ovalbumin/Polypyrrole Nanoparticles for Enhanced Phototherapy-Triggered Antitumor Immune Activation" @default.
- W4200475644 doi "https://doi.org/10.21203/rs.3.rs-1172153/v1" @default.
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