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• W4200475751 abstract "MS is a powerful methodology for chemical screening to directly quantify substrates and products of enzymes, but its low throughput has been an issue. Recently, an acoustic liquid-handling apparatus (Echo®) used for rapid nano-dispensing has been coupled to a high-sensitivity mass spectrometer to create the Echo® MS system, and we applied this system to screening of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3CL protease inhibitors. Primary screening of 32033 chemical samples was completed in 12 h. Among the hits showing selective, dose-dependent 3CL-inhibitory activity, 8 compounds showed antiviral activity in cell-based assay." @default.
• W4200475751 created "2021-12-31" @default.
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• W4200475751 date "2022-03-01" @default.
• W4200475751 modified "2023-10-14" @default.
• W4200475751 title "Application of Acoustic Ejection MS System to High-Throughput Screening for SARS-CoV-2 3CL Protease Inhibitors" @default.
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• W4200475751 doi "https://doi.org/10.1248/cpb.c21-01003" @default.
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