Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200480324> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4200480324 abstract "Abstract Background: Alcohol dependence (AD) poses a serious medical problem and significant public health issue contributing to morbidity and mortality throughout the world. The aim of the study is to test the association of rs698 ( ADH1C ) and rs671 (ALDH2 ) with the risk of alcohol dependence and to further assess the influence of environmental factors on altering the genetic susceptibility to alcoholism in south Indian Tamilian population. Methods& Results: A total of 150 alcohol dependent cases aged between 18- and 65-years fulfilling DSM-V criteria were recruited from de addiction center. Subjects in control group (n=150) had history of alcohol intake with AUDIT score less than 8. The alleles were genotyped using TaqMan SNP genotyping assays by quantitative PCR. Association with alcohol dependence was evaluated with various genetic models using chi-square test. Multiple logistic regression analysis was performed to explore the effect of covariates. The dominant (OR=0.5811,95% CI: 0.372-0.9224, p<0.01) and allelic genetic model (OR=0.6228,95% CI: 0.4328-0.9009, p<0.01) of ALDH2 , rs671 between cases and controls showed a significant association of the genetic variant with AD. Multivariate logistic regression analysis revealed education level, family history, marital status were significantly associated with AD but there was no association between rs671 genotypes in the presence of these co-variates. Conclusions : Genetic factors play an important role in alcohol dependence. Combined analysis of functional genetic variants and environmental factors is warranted in future studies." @default.
- W4200480324 created "2021-12-31" @default.
- W4200480324 creator A5018204625 @default.
- W4200480324 creator A5054065174 @default.
- W4200480324 creator A5055508741 @default.
- W4200480324 creator A5058841570 @default.
- W4200480324 date "2021-11-11" @default.
- W4200480324 modified "2023-09-26" @default.
- W4200480324 title "Association between ALDH2 Variant and Alcohol Dependence in South Indian Population." @default.
- W4200480324 doi "https://doi.org/10.21203/rs.3.rs-1046349/v1" @default.
- W4200480324 hasPublicationYear "2021" @default.
- W4200480324 type Work @default.
- W4200480324 citedByCount "0" @default.
- W4200480324 crossrefType "posted-content" @default.
- W4200480324 hasAuthorship W4200480324A5018204625 @default.
- W4200480324 hasAuthorship W4200480324A5054065174 @default.
- W4200480324 hasAuthorship W4200480324A5055508741 @default.
- W4200480324 hasAuthorship W4200480324A5058841570 @default.
- W4200480324 hasBestOaLocation W42004803241 @default.
- W4200480324 hasConcept C104317684 @default.
- W4200480324 hasConcept C126322002 @default.
- W4200480324 hasConcept C135763542 @default.
- W4200480324 hasConcept C139275648 @default.
- W4200480324 hasConcept C144024400 @default.
- W4200480324 hasConcept C149923435 @default.
- W4200480324 hasConcept C151956035 @default.
- W4200480324 hasConcept C153209595 @default.
- W4200480324 hasConcept C180754005 @default.
- W4200480324 hasConcept C186413461 @default.
- W4200480324 hasConcept C2779436514 @default.
- W4200480324 hasConcept C2781066024 @default.
- W4200480324 hasConcept C2908647359 @default.
- W4200480324 hasConcept C2992519594 @default.
- W4200480324 hasConcept C31467283 @default.
- W4200480324 hasConcept C3175096 @default.
- W4200480324 hasConcept C54355233 @default.
- W4200480324 hasConcept C55493867 @default.
- W4200480324 hasConcept C71924100 @default.
- W4200480324 hasConcept C86803240 @default.
- W4200480324 hasConcept C99454951 @default.
- W4200480324 hasConceptScore W4200480324C104317684 @default.
- W4200480324 hasConceptScore W4200480324C126322002 @default.
- W4200480324 hasConceptScore W4200480324C135763542 @default.
- W4200480324 hasConceptScore W4200480324C139275648 @default.
- W4200480324 hasConceptScore W4200480324C144024400 @default.
- W4200480324 hasConceptScore W4200480324C149923435 @default.
- W4200480324 hasConceptScore W4200480324C151956035 @default.
- W4200480324 hasConceptScore W4200480324C153209595 @default.
- W4200480324 hasConceptScore W4200480324C180754005 @default.
- W4200480324 hasConceptScore W4200480324C186413461 @default.
- W4200480324 hasConceptScore W4200480324C2779436514 @default.
- W4200480324 hasConceptScore W4200480324C2781066024 @default.
- W4200480324 hasConceptScore W4200480324C2908647359 @default.
- W4200480324 hasConceptScore W4200480324C2992519594 @default.
- W4200480324 hasConceptScore W4200480324C31467283 @default.
- W4200480324 hasConceptScore W4200480324C3175096 @default.
- W4200480324 hasConceptScore W4200480324C54355233 @default.
- W4200480324 hasConceptScore W4200480324C55493867 @default.
- W4200480324 hasConceptScore W4200480324C71924100 @default.
- W4200480324 hasConceptScore W4200480324C86803240 @default.
- W4200480324 hasConceptScore W4200480324C99454951 @default.
- W4200480324 hasLocation W42004803241 @default.
- W4200480324 hasOpenAccess W4200480324 @default.
- W4200480324 hasPrimaryLocation W42004803241 @default.
- W4200480324 hasRelatedWork W121700474 @default.
- W4200480324 hasRelatedWork W1953649435 @default.
- W4200480324 hasRelatedWork W1970279749 @default.
- W4200480324 hasRelatedWork W1992647879 @default.
- W4200480324 hasRelatedWork W2002454583 @default.
- W4200480324 hasRelatedWork W2002717359 @default.
- W4200480324 hasRelatedWork W2029870992 @default.
- W4200480324 hasRelatedWork W3004847803 @default.
- W4200480324 hasRelatedWork W4200480324 @default.
- W4200480324 hasRelatedWork W4239379028 @default.
- W4200480324 isParatext "false" @default.
- W4200480324 isRetracted "false" @default.
- W4200480324 workType "article" @default.