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- W4200480901 abstract "We analyze a mathematical model for the combination of chemotherapy with antiangiogenic treatment as a multi‐input optimal control problem. Assuming that the total amounts of both agents to be given have been determined a priori based on a medical assessment of side effects, we consider the problem to minimize a weighted average of tumor volume and the carrying capacity of the tumor vasculature. For medically realistic initial conditions and data, based on a thorough theoretical analysis of the necessary conditions for optimality given by the Pontryagin maximum principle, in this paper, the optimal administration regimen for the antiangiogenic agent is determined." @default.
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- W4200480901 date "2021-12-16" @default.
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- W4200480901 title "Combination of antiangiogenic treatment with chemotherapy as a multi‐input optimal control problem" @default.
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- W4200480901 doi "https://doi.org/10.1002/mma.7977" @default.
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