Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200483069> ?p ?o ?g. }
- W4200483069 endingPage "573" @default.
- W4200483069 startingPage "558" @default.
- W4200483069 abstract "Background: Microcirculation is essential for skin homeostasis and repair. A variety of growth factors have been identified as important regulators of wound healing. However, direct observation and longitudinal monitoring of skin remodeling in an unperturbed in vivo environment remains challenging. Methods: We report on non-invasive longitudinal imaging of the wound healing process in transgenic mice overexpressing vascular endothelial growth factor A (VEGF-A) in keratinocytes by means of large-scale optoacoustic microscopy (LSOM). This rapid, label-free, high throughput intravital microscopy method averts the use of dorsal skin-fold chambers, allowing for fully non-invasive repeated imaging of intact wounds with capillary resolution over field-of-view spanning several centimeters. Results: We observed VEGF-driven enhancement of dermal vascularization in ears, dorsal skin and healing wounds and quantified the hemoglobin content, fill fraction, vessel diameter and tortuosity. The in vivo findings were further corroborated by detailed side-by-side classical histological whole-mount vascular stainings and pan-endothelial CD31 immunofluorescence. Conclusion: The new approach is suitable for supplementing or replacing the cumbersome histological procedures in a broad range of skin regeneration and tissue engineering applications." @default.
- W4200483069 created "2021-12-31" @default.
- W4200483069 creator A5007653586 @default.
- W4200483069 creator A5045984361 @default.
- W4200483069 creator A5060019261 @default.
- W4200483069 creator A5068712407 @default.
- W4200483069 creator A5072684314 @default.
- W4200483069 creator A5077079745 @default.
- W4200483069 creator A5082319905 @default.
- W4200483069 date "2022-01-01" @default.
- W4200483069 modified "2023-09-30" @default.
- W4200483069 title "Non-invasive longitudinal imaging of VEGF-induced microvascular alterations in skin wounds" @default.
- W4200483069 cites W1149291733 @default.
- W4200483069 cites W1613798522 @default.
- W4200483069 cites W1971248512 @default.
- W4200483069 cites W1981080687 @default.
- W4200483069 cites W1989483643 @default.
- W4200483069 cites W1999790410 @default.
- W4200483069 cites W2013538303 @default.
- W4200483069 cites W2020476250 @default.
- W4200483069 cites W2022022828 @default.
- W4200483069 cites W2022490022 @default.
- W4200483069 cites W2022655957 @default.
- W4200483069 cites W2033432515 @default.
- W4200483069 cites W2035286393 @default.
- W4200483069 cites W2035371785 @default.
- W4200483069 cites W2054499486 @default.
- W4200483069 cites W2059802118 @default.
- W4200483069 cites W2067117198 @default.
- W4200483069 cites W2074992632 @default.
- W4200483069 cites W2075097705 @default.
- W4200483069 cites W2106577067 @default.
- W4200483069 cites W2111587806 @default.
- W4200483069 cites W2121039615 @default.
- W4200483069 cites W2127903487 @default.
- W4200483069 cites W2135473957 @default.
- W4200483069 cites W2139837799 @default.
- W4200483069 cites W2156822877 @default.
- W4200483069 cites W2167279371 @default.
- W4200483069 cites W2169133530 @default.
- W4200483069 cites W2207453047 @default.
- W4200483069 cites W2506494295 @default.
- W4200483069 cites W2548186030 @default.
- W4200483069 cites W2615708404 @default.
- W4200483069 cites W2781767175 @default.
- W4200483069 cites W2792609028 @default.
- W4200483069 cites W2801399992 @default.
- W4200483069 cites W2815926600 @default.
- W4200483069 cites W2890388902 @default.
- W4200483069 cites W2903506831 @default.
- W4200483069 cites W2905586104 @default.
- W4200483069 cites W2969821467 @default.
- W4200483069 cites W2975440314 @default.
- W4200483069 cites W3002720628 @default.
- W4200483069 cites W3005566579 @default.
- W4200483069 cites W3011378399 @default.
- W4200483069 cites W3035660770 @default.
- W4200483069 cites W3082315064 @default.
- W4200483069 cites W3082840904 @default.
- W4200483069 cites W3159895826 @default.
- W4200483069 cites W3162626557 @default.
- W4200483069 doi "https://doi.org/10.7150/thno.65287" @default.
- W4200483069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34976201" @default.
- W4200483069 hasPublicationYear "2022" @default.
- W4200483069 type Work @default.
- W4200483069 citedByCount "13" @default.
- W4200483069 countsByYear W42004830692022 @default.
- W4200483069 countsByYear W42004830692023 @default.
- W4200483069 crossrefType "journal-article" @default.
- W4200483069 hasAuthorship W4200483069A5007653586 @default.
- W4200483069 hasAuthorship W4200483069A5045984361 @default.
- W4200483069 hasAuthorship W4200483069A5060019261 @default.
- W4200483069 hasAuthorship W4200483069A5068712407 @default.
- W4200483069 hasAuthorship W4200483069A5072684314 @default.
- W4200483069 hasAuthorship W4200483069A5077079745 @default.
- W4200483069 hasAuthorship W4200483069A5082319905 @default.
- W4200483069 hasBestOaLocation W42004830691 @default.
- W4200483069 hasConcept C105702510 @default.
- W4200483069 hasConcept C126838900 @default.
- W4200483069 hasConcept C12722491 @default.
- W4200483069 hasConcept C136229726 @default.
- W4200483069 hasConcept C140530291 @default.
- W4200483069 hasConcept C141071460 @default.
- W4200483069 hasConcept C142724271 @default.
- W4200483069 hasConcept C150903083 @default.
- W4200483069 hasConcept C167734588 @default.
- W4200483069 hasConcept C171056886 @default.
- W4200483069 hasConcept C190567982 @default.
- W4200483069 hasConcept C204232928 @default.
- W4200483069 hasConcept C207001950 @default.
- W4200483069 hasConcept C26291073 @default.
- W4200483069 hasConcept C2777025900 @default.
- W4200483069 hasConcept C2778271429 @default.
- W4200483069 hasConcept C2778939058 @default.
- W4200483069 hasConcept C2780269544 @default.
- W4200483069 hasConcept C2780394083 @default.
- W4200483069 hasConcept C2859252 @default.
- W4200483069 hasConcept C502942594 @default.