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• W4200483408 abstract "Pinus roxburghii commonly known as “chir pine” belongs to the family Pinaceae and is one of the ornamental trees having tremendous medicinal values placed all over the temperate territory of the northern hemisphere including the Himalayas. There is a global interest in the scientific community to identify novel therapeutic agents that may fight against cancer. In the present study, ethyl acetate fractions (EAF) of green and fallen needles of Pinus roxburghii from the Himalayan region of Himachal Pradesh, India were investigated for immunostimulatory potential toward cancer reduction under both in vitro and in vivo conditions. The previous preliminary study is baselined for the novel idea of using ethyl acetate fractions of green and fallen needles of Pinus roxburghii to assess immunomodulation on Ehrlich ascites carcinoma (EAC) tumor model among six extracts and fractions. A 10 mg/kg body weight of EAF was injected intraperitoneally for 7 days for immunostimulation of mice prior to cancer induction and compared with standard immunostimulator levamisole. After 14 days of EAC inoculation, hematological, biochemical parameters and vital organs were analyzed. The in vitro data depicted that EAF of green and fallen needles of P. roxburghii possessed the highest immunoenhancing potential on human peripheral blood lymphocytes. Pre-treatment with EAF at 10 mg/kg of the body weight, enhanced the mean survival time to (% ILS=55) and (% ILS=58) respectively in percentage increased life span, whereas it was found to be (% ILS=78) for levamisole. Moreover, EAF of both needles indicated a reduction in tumor growth up to 70.3% while levamisole exhibited 85.4% compared to tumor control groups via immune boosting. Histological examinations revealed enhanced cell number and increased sizes of spleen and thymus indicating boosted immunological responses of EAFs. Hematological and biochemical parameters were recorded to be normal compared to tumor control. The study presented here proved that EAF of green and fallen needles of P. roxburghii have a novel, potential and rich source of immune-boosting phytochemicals for fighting tumor development. Therefore EAF of the needles may be used to develop novel alternative immune boosters which can fight against the development of various types of cancers." @default.
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• W4200483408 date "2022-09-01" @default.
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• W4200483408 title "Immunomodulatory potential of the ethyl acetate fraction of Pinus roxburghii from the Himalayan region of India towards Ehrlich ascites carcinoma" @default.
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• W4200483408 doi "https://doi.org/10.1016/j.sajb.2021.12.001" @default.
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