FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200489013> ?p ?o ?g. }

• W4200489013 endingPage "86" @default.
• W4200489013 startingPage "83" @default.
• W4200489013 abstract "To evaluate the real-world impact of using a commercially available combinatorial pharmacogenomic (CPGx) test on medication management and clinical outcomes in children and adolescents treated at a tertiary care psychiatry practice.A retrospective cohort study using our prospectively maintained database of patients undergoing CPGx testing was performed. Only patients with clinical data at the time of ordering CPGx test (pre-baseline), potential medication change visit (baseline) and 8-weeks follow-up (post-baseline) visit were included. Clinical Global Impression (CGI) scores for each visit were calculated. Appropriate statistical analysis, including one-sample t-test, paired t-test and Chi-square test was performed.Based on the inclusion criteria, 281 (75.9%) of the 370 patients with CPGx testing were included. Their mean age was 15.8 ± 4.5 years (111 females; 39.5%). The average number of medications significantly increased to 2.4 ± 1.2 on the post-baseline visit [t(280) = 8.34, p < 0.001). Medications were added in 123 (43.7%), replaced in 92 (32.7%) patients and remained unchanged in rest. There was no significant association between medication-related adverse effects and psychotropic medication change group (p = 0.27). The study population showed a significant improvement (p < 0.001) in the CGI severity, efficacy, and global improvement indices.In our experience of using CPGx test in a large cohort of children and adolescents during routine clinical practice, three-quarter of them underwent medication change. Additionally, we noted an improvement in clinical outcomes without impacting adverse effects. While the role of clinical judgement in medication changes in our cohort is likely, CPGx may supplement clinical decision making. However, the best use and benefit of CPGx in routine clinical practice needs further investigation." @default.
• W4200489013 created "2021-12-31" @default.
• W4200489013 creator A5018130061 @default.
• W4200489013 creator A5021499104 @default.
• W4200489013 creator A5026428934 @default.
• W4200489013 creator A5047262113 @default.
• W4200489013 creator A5050382772 @default.
• W4200489013 creator A5053230942 @default.
• W4200489013 creator A5066114879 @default.
• W4200489013 creator A5088231471 @default.
• W4200489013 date "2022-02-01" @default.
• W4200489013 modified "2023-10-05" @default.
• W4200489013 title "Real-world experience of using combinatorial pharmacogenomic test in children and adolescents with depression and anxiety" @default.
• W4200489013 cites W1723350759 @default.
• W4200489013 cites W1975609229 @default.
• W4200489013 cites W2002319839 @default.
• W4200489013 cites W2003385727 @default.
• W4200489013 cites W2013357899 @default.
• W4200489013 cites W2030226551 @default.
• W4200489013 cites W2065844121 @default.
• W4200489013 cites W2161620765 @default.
• W4200489013 cites W2590397033 @default.
• W4200489013 cites W2614101904 @default.
• W4200489013 cites W2791570487 @default.
• W4200489013 cites W2795465735 @default.
• W4200489013 cites W2805675485 @default.
• W4200489013 cites W2893252546 @default.
• W4200489013 cites W2908242089 @default.
• W4200489013 cites W3011626907 @default.
• W4200489013 cites W3016606559 @default.
• W4200489013 cites W3025281002 @default.
• W4200489013 cites W3111048839 @default.
• W4200489013 doi "https://doi.org/10.1016/j.jpsychires.2021.12.037" @default.
• W4200489013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34959162" @default.
• W4200489013 hasPublicationYear "2022" @default.
• W4200489013 type Work @default.
• W4200489013 citedByCount "3" @default.
• W4200489013 countsByYear W42004890132022 @default.
• W4200489013 countsByYear W42004890132023 @default.
• W4200489013 crossrefType "journal-article" @default.
• W4200489013 hasAuthorship W4200489013A5018130061 @default.
• W4200489013 hasAuthorship W4200489013A5021499104 @default.
• W4200489013 hasAuthorship W4200489013A5026428934 @default.
• W4200489013 hasAuthorship W4200489013A5047262113 @default.
• W4200489013 hasAuthorship W4200489013A5050382772 @default.
• W4200489013 hasAuthorship W4200489013A5053230942 @default.
• W4200489013 hasAuthorship W4200489013A5066114879 @default.
• W4200489013 hasAuthorship W4200489013A5088231471 @default.
• W4200489013 hasConcept C118552586 @default.
• W4200489013 hasConcept C126322002 @default.
• W4200489013 hasConcept C139719470 @default.
• W4200489013 hasConcept C142724271 @default.
• W4200489013 hasConcept C162324750 @default.
• W4200489013 hasConcept C167135981 @default.
• W4200489013 hasConcept C1862650 @default.
• W4200489013 hasConcept C197934379 @default.
• W4200489013 hasConcept C201903717 @default.
• W4200489013 hasConcept C204787440 @default.
• W4200489013 hasConcept C27081682 @default.
• W4200489013 hasConcept C2776000289 @default.
• W4200489013 hasConcept C2776867660 @default.
• W4200489013 hasConcept C2908647359 @default.
• W4200489013 hasConcept C535046627 @default.
• W4200489013 hasConcept C558461103 @default.
• W4200489013 hasConcept C71924100 @default.
• W4200489013 hasConcept C72563966 @default.
• W4200489013 hasConcept C99454951 @default.
• W4200489013 hasConceptScore W4200489013C118552586 @default.
• W4200489013 hasConceptScore W4200489013C126322002 @default.
• W4200489013 hasConceptScore W4200489013C139719470 @default.
• W4200489013 hasConceptScore W4200489013C142724271 @default.
• W4200489013 hasConceptScore W4200489013C162324750 @default.
• W4200489013 hasConceptScore W4200489013C167135981 @default.
• W4200489013 hasConceptScore W4200489013C1862650 @default.
• W4200489013 hasConceptScore W4200489013C197934379 @default.
• W4200489013 hasConceptScore W4200489013C201903717 @default.
• W4200489013 hasConceptScore W4200489013C204787440 @default.
• W4200489013 hasConceptScore W4200489013C27081682 @default.
• W4200489013 hasConceptScore W4200489013C2776000289 @default.
• W4200489013 hasConceptScore W4200489013C2776867660 @default.
• W4200489013 hasConceptScore W4200489013C2908647359 @default.
• W4200489013 hasConceptScore W4200489013C535046627 @default.
• W4200489013 hasConceptScore W4200489013C558461103 @default.
• W4200489013 hasConceptScore W4200489013C71924100 @default.
• W4200489013 hasConceptScore W4200489013C72563966 @default.
• W4200489013 hasConceptScore W4200489013C99454951 @default.
• W4200489013 hasLocation W42004890131 @default.
• W4200489013 hasLocation W42004890132 @default.
• W4200489013 hasOpenAccess W4200489013 @default.
• W4200489013 hasPrimaryLocation W42004890131 @default.
• W4200489013 hasRelatedWork W2318499231 @default.
• W4200489013 hasRelatedWork W2342034961 @default.
• W4200489013 hasRelatedWork W2727005442 @default.
• W4200489013 hasRelatedWork W3002203907 @default.
• W4200489013 hasRelatedWork W4281392583 @default.
• W4200489013 hasRelatedWork W4313537896 @default.
• W4200489013 hasRelatedWork W4315641902 @default.
• W4200489013 hasRelatedWork W4318960897 @default.

• next