Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200489171> ?p ?o ?g. }
- W4200489171 endingPage "403" @default.
- W4200489171 startingPage "390" @default.
- W4200489171 abstract "Pre-mRNA processing factor 19 (PRP19) is elevated in hepatocellular carcinoma (HCC); however, little is known about its function in DNA damage repair in HCC. In this study, analysis of The Cancer Genome Atlas data and our tumor models after ionizing radiation (IR) treatment indicated that increased expression of PRP19 was positively correlated with DNA damage repair. Gain of PRP19 expression induced by plasmids resulted in decreases in apoptosis and double-strand breaks (DSBs), and an increase in cell survival after IR. Loss of PRP19 expression induced by small interfering RNAs resulted in the accumulation of apoptosis and DSBs, and a decrease in cell survival. Mechanistically, the effect of PRP19 on DNA damage repair was mediated by the modulation of cyclin D1 expression in HCC. PRP19 controlled the translation of cyclin D1 by modulating eukaryotic initiation factor 4E. PRP19 affected the DNA damage repair ability of cyclin D1 by interacting with the WD40 domain. The combination of PRP19 and cyclin D1 was more valuable than each single marker for predicting the prognosis of patients. Taken together, the present results demonstrate that PRP19 promotes DNA damage repair by modulating cyclin D1 expression and function, thereby contributing to the radioresistance in HCC." @default.
- W4200489171 created "2021-12-31" @default.
- W4200489171 creator A5006869577 @default.
- W4200489171 creator A5013019322 @default.
- W4200489171 creator A5024243296 @default.
- W4200489171 creator A5024981671 @default.
- W4200489171 creator A5026672123 @default.
- W4200489171 creator A5027537295 @default.
- W4200489171 creator A5045539030 @default.
- W4200489171 creator A5061943067 @default.
- W4200489171 creator A5077934665 @default.
- W4200489171 date "2022-03-01" @default.
- W4200489171 modified "2023-10-09" @default.
- W4200489171 title "Pre-mRNA processing factor 19 functions in DNA damage repair and radioresistance by modulating cyclin D1 in hepatocellular carcinoma" @default.
- W4200489171 cites W127046385 @default.
- W4200489171 cites W1964675052 @default.
- W4200489171 cites W1974717425 @default.
- W4200489171 cites W1977107145 @default.
- W4200489171 cites W1981650365 @default.
- W4200489171 cites W1988043615 @default.
- W4200489171 cites W2002790336 @default.
- W4200489171 cites W2014231271 @default.
- W4200489171 cites W2018979721 @default.
- W4200489171 cites W2027078925 @default.
- W4200489171 cites W2028818944 @default.
- W4200489171 cites W2030800943 @default.
- W4200489171 cites W2033204767 @default.
- W4200489171 cites W2038154009 @default.
- W4200489171 cites W2049494471 @default.
- W4200489171 cites W2050234011 @default.
- W4200489171 cites W2058354053 @default.
- W4200489171 cites W2120633040 @default.
- W4200489171 cites W2132396299 @default.
- W4200489171 cites W2151252396 @default.
- W4200489171 cites W2169024046 @default.
- W4200489171 cites W2170040956 @default.
- W4200489171 cites W2176840914 @default.
- W4200489171 cites W2222797022 @default.
- W4200489171 cites W2236127431 @default.
- W4200489171 cites W2281629727 @default.
- W4200489171 cites W2302060882 @default.
- W4200489171 cites W2527438532 @default.
- W4200489171 cites W2554016416 @default.
- W4200489171 cites W2604434335 @default.
- W4200489171 cites W2610280068 @default.
- W4200489171 cites W2626897616 @default.
- W4200489171 cites W2750728167 @default.
- W4200489171 cites W2783863967 @default.
- W4200489171 cites W2809156896 @default.
- W4200489171 cites W2889646458 @default.
- W4200489171 cites W2918252715 @default.
- W4200489171 cites W2926997511 @default.
- W4200489171 cites W2979871383 @default.
- W4200489171 cites W2988943665 @default.
- W4200489171 cites W3003445183 @default.
- W4200489171 cites W3012034503 @default.
- W4200489171 cites W3012868447 @default.
- W4200489171 cites W3016248999 @default.
- W4200489171 cites W3085552444 @default.
- W4200489171 cites W3090809699 @default.
- W4200489171 cites W3108592360 @default.
- W4200489171 cites W4210955410 @default.
- W4200489171 doi "https://doi.org/10.1016/j.omtn.2021.12.002" @default.
- W4200489171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35036052" @default.
- W4200489171 hasPublicationYear "2022" @default.
- W4200489171 type Work @default.
- W4200489171 citedByCount "6" @default.
- W4200489171 countsByYear W42004891712022 @default.
- W4200489171 countsByYear W42004891712023 @default.
- W4200489171 crossrefType "journal-article" @default.
- W4200489171 hasAuthorship W4200489171A5006869577 @default.
- W4200489171 hasAuthorship W4200489171A5013019322 @default.
- W4200489171 hasAuthorship W4200489171A5024243296 @default.
- W4200489171 hasAuthorship W4200489171A5024981671 @default.
- W4200489171 hasAuthorship W4200489171A5026672123 @default.
- W4200489171 hasAuthorship W4200489171A5027537295 @default.
- W4200489171 hasAuthorship W4200489171A5045539030 @default.
- W4200489171 hasAuthorship W4200489171A5061943067 @default.
- W4200489171 hasAuthorship W4200489171A5077934665 @default.
- W4200489171 hasBestOaLocation W42004891711 @default.
- W4200489171 hasConcept C134935766 @default.
- W4200489171 hasConcept C143425029 @default.
- W4200489171 hasConcept C190283241 @default.
- W4200489171 hasConcept C199835354 @default.
- W4200489171 hasConcept C29537977 @default.
- W4200489171 hasConcept C502942594 @default.
- W4200489171 hasConcept C54355233 @default.
- W4200489171 hasConcept C552990157 @default.
- W4200489171 hasConcept C58962609 @default.
- W4200489171 hasConcept C81885089 @default.
- W4200489171 hasConcept C86803240 @default.
- W4200489171 hasConcept C95444343 @default.
- W4200489171 hasConceptScore W4200489171C134935766 @default.
- W4200489171 hasConceptScore W4200489171C143425029 @default.
- W4200489171 hasConceptScore W4200489171C190283241 @default.
- W4200489171 hasConceptScore W4200489171C199835354 @default.
- W4200489171 hasConceptScore W4200489171C29537977 @default.
- W4200489171 hasConceptScore W4200489171C502942594 @default.