Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200489459> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4200489459 endingPage "S29" @default.
- W4200489459 startingPage "S29" @default.
- W4200489459 abstract "Valproate has been used for over 30 years as a first-line treatment for epilepsy. In recent years, prenatal exposure to valproate has been associated with teratogenic effects, limiting its use in women that are pregnant or of childbearing age. However, despite its potential detrimental effects on development, valproate continues to be prescribed at high rates in pediatric populations in some countries. Animal models allow us to test hypotheses regarding the potential effects of postnatal valproate exposure on neurobehavioral development, as well as identify potential mechanisms mediating observed effects. Here, we tested the effect of early postnatal (P4–P11) valproate exposure (100 mg/kg and 200 mg/kg) on motor and affective development in two strains of mice, SVE129 and C57Bl/6N. We also assessed the effect of early valproate exposure on regional BDNF protein levels, a potential target of valproate, and mediator of neurodevelopmental outcomes. We found that early life valproate exposure led to significant motor impairments in both SVE129 and C57Bl/6N mice. Both lines of mice showed significant delays in weight gain, as well as impairments in the righting reflex (P7–8), wire hang (P17), open field (P12 and P21), and rotarod (P25 and P45) tasks. Interestingly, some of the early locomotor effects were strain- and dose-dependent. We observed no effects of valproate on early markers of anxiety-like behavior. Importantly, early life valproate exposure had significant effects on regional BDNF expression, leading to a near 50% decrease in BDNF levels in the cerebellum of both strains of mice, while not impacting hippocampal BDNF protein levels. These observations indicate that postnatal exposure to valproate may have significant, and region-specific effects, on neural and behavioral development, with specific consequences for cerebellar development and motor function." @default.
- W4200489459 created "2021-12-31" @default.
- W4200489459 creator A5004220508 @default.
- W4200489459 creator A5023157764 @default.
- W4200489459 creator A5040608206 @default.
- W4200489459 creator A5058708756 @default.
- W4200489459 creator A5065175074 @default.
- W4200489459 creator A5074270488 @default.
- W4200489459 date "2021-12-01" @default.
- W4200489459 modified "2023-10-06" @default.
- W4200489459 title "P.0039 Gender-related differences in the social behavior of Wistar rats after chronic postnatal administration of valproic acid" @default.
- W4200489459 cites W1966452992 @default.
- W4200489459 cites W2810453228 @default.
- W4200489459 doi "https://doi.org/10.1016/j.euroneuro.2021.10.044" @default.
- W4200489459 hasPublicationYear "2021" @default.
- W4200489459 type Work @default.
- W4200489459 citedByCount "0" @default.
- W4200489459 crossrefType "journal-article" @default.
- W4200489459 hasAuthorship W4200489459A5004220508 @default.
- W4200489459 hasAuthorship W4200489459A5023157764 @default.
- W4200489459 hasAuthorship W4200489459A5040608206 @default.
- W4200489459 hasAuthorship W4200489459A5058708756 @default.
- W4200489459 hasAuthorship W4200489459A5065175074 @default.
- W4200489459 hasAuthorship W4200489459A5074270488 @default.
- W4200489459 hasConcept C112672928 @default.
- W4200489459 hasConcept C113062710 @default.
- W4200489459 hasConcept C118552586 @default.
- W4200489459 hasConcept C126322002 @default.
- W4200489459 hasConcept C131783052 @default.
- W4200489459 hasConcept C134018914 @default.
- W4200489459 hasConcept C15744967 @default.
- W4200489459 hasConcept C2777172819 @default.
- W4200489459 hasConcept C2778186239 @default.
- W4200489459 hasConcept C2779085643 @default.
- W4200489459 hasConcept C2779234561 @default.
- W4200489459 hasConcept C42407357 @default.
- W4200489459 hasConcept C54355233 @default.
- W4200489459 hasConcept C71924100 @default.
- W4200489459 hasConcept C83974742 @default.
- W4200489459 hasConcept C86803240 @default.
- W4200489459 hasConceptScore W4200489459C112672928 @default.
- W4200489459 hasConceptScore W4200489459C113062710 @default.
- W4200489459 hasConceptScore W4200489459C118552586 @default.
- W4200489459 hasConceptScore W4200489459C126322002 @default.
- W4200489459 hasConceptScore W4200489459C131783052 @default.
- W4200489459 hasConceptScore W4200489459C134018914 @default.
- W4200489459 hasConceptScore W4200489459C15744967 @default.
- W4200489459 hasConceptScore W4200489459C2777172819 @default.
- W4200489459 hasConceptScore W4200489459C2778186239 @default.
- W4200489459 hasConceptScore W4200489459C2779085643 @default.
- W4200489459 hasConceptScore W4200489459C2779234561 @default.
- W4200489459 hasConceptScore W4200489459C42407357 @default.
- W4200489459 hasConceptScore W4200489459C54355233 @default.
- W4200489459 hasConceptScore W4200489459C71924100 @default.
- W4200489459 hasConceptScore W4200489459C83974742 @default.
- W4200489459 hasConceptScore W4200489459C86803240 @default.
- W4200489459 hasFunder F4320321079 @default.
- W4200489459 hasLocation W42004894591 @default.
- W4200489459 hasOpenAccess W4200489459 @default.
- W4200489459 hasPrimaryLocation W42004894591 @default.
- W4200489459 hasRelatedWork W1591616590 @default.
- W4200489459 hasRelatedWork W1994020831 @default.
- W4200489459 hasRelatedWork W2009428258 @default.
- W4200489459 hasRelatedWork W2047787624 @default.
- W4200489459 hasRelatedWork W2064652474 @default.
- W4200489459 hasRelatedWork W2110681150 @default.
- W4200489459 hasRelatedWork W2127828366 @default.
- W4200489459 hasRelatedWork W2748952813 @default.
- W4200489459 hasRelatedWork W3160140598 @default.
- W4200489459 hasRelatedWork W4243955373 @default.
- W4200489459 hasVolume "53" @default.
- W4200489459 isParatext "false" @default.
- W4200489459 isRetracted "false" @default.
- W4200489459 workType "article" @default.