Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200491303> ?p ?o ?g. }
- W4200491303 endingPage "e1009708" @default.
- W4200491303 startingPage "e1009708" @default.
- W4200491303 abstract "Many enzymes in one-carbon metabolism (OCM) are up- or down-regulated by the sex hormones which vary diurnally and throughout the menstrual cycle. During pregnancy, estradiol and progesterone levels increase tremendously to modulate physiological changes in the reproductive system. In this work, we extend and improve an existing mathematical model of hepatic OCM to understand the dynamic metabolic changes that happen during the menstrual cycle and pregnancy due to estradiol variation. In particular, we add the polyamine drain on S-adenosyl methionine and the direct effects of estradiol on the enzymes cystathionine β-synthase (CBS), thymidylate synthase (TS), and dihydrofolate reductase (DHFR). We show that the homocysteine concentration varies inversely with estradiol concentration, discuss the fluctuations in 14 other one-carbon metabolites and velocities throughout the menstrual cycle, and draw comparisons with the literature. We then use the model to study the effects of vitamin B12, vitamin B6, and folate deficiencies and explain why homocysteine is not a good biomarker for vitamin deficiencies. Additionally, we compute homocysteine throughout pregnancy, and compare the results with experimental data. Our mathematical model explains how numerous homeostatic mechanisms in OCM function and provides new insights into how homocysteine and its deleterious effects are influenced by estradiol. The mathematical model can be used by others for further in silico experiments on changes in one-carbon metabolism during the menstrual cycle and pregnancy." @default.
- W4200491303 created "2021-12-31" @default.
- W4200491303 creator A5004407209 @default.
- W4200491303 creator A5009627001 @default.
- W4200491303 creator A5047159374 @default.
- W4200491303 date "2021-12-16" @default.
- W4200491303 modified "2023-10-01" @default.
- W4200491303 title "One-carbon metabolism during the menstrual cycle and pregnancy" @default.
- W4200491303 cites W1422828073 @default.
- W4200491303 cites W1521598897 @default.
- W4200491303 cites W1534159769 @default.
- W4200491303 cites W1537972189 @default.
- W4200491303 cites W1564357961 @default.
- W4200491303 cites W1668732801 @default.
- W4200491303 cites W1727895137 @default.
- W4200491303 cites W1891967301 @default.
- W4200491303 cites W1909488426 @default.
- W4200491303 cites W1965581424 @default.
- W4200491303 cites W1965729439 @default.
- W4200491303 cites W1967204337 @default.
- W4200491303 cites W1969636015 @default.
- W4200491303 cites W1975357252 @default.
- W4200491303 cites W1985753645 @default.
- W4200491303 cites W1986192026 @default.
- W4200491303 cites W1990324969 @default.
- W4200491303 cites W2013034393 @default.
- W4200491303 cites W2016670894 @default.
- W4200491303 cites W2023526793 @default.
- W4200491303 cites W2024070669 @default.
- W4200491303 cites W2028294233 @default.
- W4200491303 cites W2030963729 @default.
- W4200491303 cites W2043295519 @default.
- W4200491303 cites W2050826226 @default.
- W4200491303 cites W2051136548 @default.
- W4200491303 cites W2054292719 @default.
- W4200491303 cites W2057354497 @default.
- W4200491303 cites W2069132215 @default.
- W4200491303 cites W2072831812 @default.
- W4200491303 cites W2084211762 @default.
- W4200491303 cites W2084715871 @default.
- W4200491303 cites W2091403555 @default.
- W4200491303 cites W2098171025 @default.
- W4200491303 cites W2108484297 @default.
- W4200491303 cites W2111696544 @default.
- W4200491303 cites W2116143765 @default.
- W4200491303 cites W2119262508 @default.
- W4200491303 cites W2126312158 @default.
- W4200491303 cites W2135055848 @default.
- W4200491303 cites W2144886407 @default.
- W4200491303 cites W2149886788 @default.
- W4200491303 cites W2150848628 @default.
- W4200491303 cites W2155145341 @default.
- W4200491303 cites W2155870343 @default.
- W4200491303 cites W2161299653 @default.
- W4200491303 cites W2165905870 @default.
- W4200491303 cites W2403198051 @default.
- W4200491303 cites W2590927447 @default.
- W4200491303 cites W2618323132 @default.
- W4200491303 cites W2640267936 @default.
- W4200491303 cites W2738206265 @default.
- W4200491303 cites W2793361286 @default.
- W4200491303 cites W2893363828 @default.
- W4200491303 cites W2896658827 @default.
- W4200491303 cites W2898409819 @default.
- W4200491303 cites W3034451780 @default.
- W4200491303 cites W3215299411 @default.
- W4200491303 cites W4210987687 @default.
- W4200491303 doi "https://doi.org/10.1371/journal.pcbi.1009708" @default.
- W4200491303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34914693" @default.
- W4200491303 hasPublicationYear "2021" @default.
- W4200491303 type Work @default.
- W4200491303 citedByCount "1" @default.
- W4200491303 countsByYear W42004913032023 @default.
- W4200491303 crossrefType "journal-article" @default.
- W4200491303 hasAuthorship W4200491303A5004407209 @default.
- W4200491303 hasAuthorship W4200491303A5009627001 @default.
- W4200491303 hasAuthorship W4200491303A5047159374 @default.
- W4200491303 hasBestOaLocation W42004913031 @default.
- W4200491303 hasConcept C104317684 @default.
- W4200491303 hasConcept C126322002 @default.
- W4200491303 hasConcept C134018914 @default.
- W4200491303 hasConcept C135763542 @default.
- W4200491303 hasConcept C16525657 @default.
- W4200491303 hasConcept C2777090595 @default.
- W4200491303 hasConcept C2778087339 @default.
- W4200491303 hasConcept C2779058012 @default.
- W4200491303 hasConcept C2779234561 @default.
- W4200491303 hasConcept C2780912031 @default.
- W4200491303 hasConcept C43563269 @default.
- W4200491303 hasConcept C515207424 @default.
- W4200491303 hasConcept C54355233 @default.
- W4200491303 hasConcept C55493867 @default.
- W4200491303 hasConcept C62231903 @default.
- W4200491303 hasConcept C71315377 @default.
- W4200491303 hasConcept C71924100 @default.
- W4200491303 hasConcept C80315684 @default.
- W4200491303 hasConcept C86803240 @default.
- W4200491303 hasConceptScore W4200491303C104317684 @default.