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- W4200492043 abstract "Abstract Purpose: The goal of this study was to investigate the effect of orphan G Protein-Coupled Receptor 50 (GPR50) receptor on inflammation and insulin signaling in 3T3-L1 preadipocyte. Subjects and Methods: A high-fat diet (HFD)-induced obesity-T2DM (Type 2 Diabetes Mellitus) mouse model was used in this research, and high expression of GPR50 in mouse adipose tissue was screened by microarray technology. Expression of GPR50 in 3T3-L1 cell line and obesity-T2DM mouse adipose tissue was confirmed. To gain more insight into the potential role of this new target in obesity-associated IR development, a GPR50 knockout cell line was constructed in 3T3-L1 cell line. Inflammatory cytokine levels and insulin signaling pathways in the GPR50 knockout 3T3-L1 cell line were determined by quantitative real-time polymerase chain reaction analysis and western blot. Results: GPR50 expression was significantly increased in adipose tissue of obesity-T2DM mice. GPR50 deficiency increased inflammation in 3T3-L1 cells. In addition, GPR50 deficiency induced the phosphorylation of AKT and insulin receptor substrate (IRS)1. Furthermore, GPR50 knockout 3T3-L1 cell line had suppressed PPAR-γ expression. Conclusions: These data demonstrated a novel target GPR50 can affect inflammation and insulin signaling in adipocytes. Furthermore, the effects are mediated through the regulation of insulin signaling and PPAR-γ expression." @default.
- W4200492043 created "2021-12-31" @default.
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- W4200492043 date "2021-12-03" @default.
- W4200492043 modified "2023-09-27" @default.
- W4200492043 title "Orphan Receptor GPR50 Improves Inflammation and Insulin Signaling in 3T3-L1 Preadipocyte" @default.
- W4200492043 doi "https://doi.org/10.21203/rs.3.rs-1117111/v1" @default.
- W4200492043 hasPublicationYear "2021" @default.
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