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- W4200492094 abstract "Chromofungin (CHR: chromogranin-A 47-66) is a chromogranin-A derived peptide with anti-inflammatory and anti-microbial properties. Ulcerative colitis (UC) is characterized by a colonic decrease of CHR and a dysregulation of dendritic CD11c+ cells.To investigate the association between CHR treatment and dendritic cells (DCs)-related markers in different immune compartments in colitis.A model of acute UC-like colitis using dextran sulphate sodium (DSS) was used in addition to biopsies collected from UC patients.Intrarectal CHR treatment reduced the severity of DSS-induced colitis and was associated with a significant decrease in the expression of CD11c, CD40, CD80, CD86 and interleukin (IL)-12p40 in the inflamed colonic mucosa and CD11c, CD80, CD86 IL-6 and IL-12p40 within the mesenteric lymph nodes and the spleen. Furthermore, CHR treatment decreased CD80 and CD86 expression markers of splenic CD11c+ cells and decreased NF-κB expression in the colon and of splenic CD11c+ cells. In vitro, CHR decreased CD40, CD80, CD86 IL-6 and IL-12p40 expression in naïve bone marrow-derived CD11c+ DCs stimulated with lipopolysaccharide. Pharmacological studies demonstrated an impact of CHR on the NF-κB pathway. In patients with active UC, CHR level was reduced and showed a negative linear relationship with CD11c and CD86.CHR has protective properties against intestinal inflammation via the regulation of DC-related markers and CD11c+ cells. CHR could be a potential therapy of UC." @default.
- W4200492094 created "2021-12-31" @default.
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- W4200492094 date "2021-12-21" @default.
- W4200492094 modified "2023-10-17" @default.
- W4200492094 title "Impact of intrarectal chromofungin treatment on dendritic cells-related markers in different immune compartments in colonic inflammatory conditions" @default.
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- W4200492094 cites W1855226200 @default.
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- W4200492094 cites W1965627667 @default.
- W4200492094 cites W1966019227 @default.
- W4200492094 cites W1968574722 @default.
- W4200492094 cites W1970620760 @default.
- W4200492094 cites W1970841758 @default.
- W4200492094 cites W1971104055 @default.
- W4200492094 cites W1984387148 @default.
- W4200492094 cites W1988673661 @default.
- W4200492094 cites W1997708871 @default.
- W4200492094 cites W1999307846 @default.
- W4200492094 cites W1999855196 @default.
- W4200492094 cites W2003085334 @default.
- W4200492094 cites W2006776875 @default.
- W4200492094 cites W2010204828 @default.
- W4200492094 cites W2013021373 @default.
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- W4200492094 cites W2028310975 @default.
- W4200492094 cites W2038122919 @default.
- W4200492094 cites W2047208232 @default.
- W4200492094 cites W2048434238 @default.
- W4200492094 cites W2058178626 @default.
- W4200492094 cites W2071327437 @default.
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- W4200492094 cites W2235521759 @default.
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- W4200492094 cites W2340097563 @default.
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- W4200492094 doi "https://doi.org/10.3748/wjg.v27.i47.8138" @default.
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