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- W4200493036 abstract "Coxiella burnetii is a bacterial pathogen that replicates within host cells by establishing a membrane-bound niche called the Coxiella-containing vacuole. Biogenesis of this compartment requires effectors of its Dot/Icm type IV secretion system. A large cohort of such effectors has been identified, but the function of most of them remain elusive. Here, by a cell-based functional screening, we identified the effector Cbu0513 (designated as CinF) as an inhibitor of NF-κB signaling. CinF is highly similar to a fructose-1,6-bisphosphate (FBP) aldolase/phosphatase present in diverse bacteria. Further study reveals that unlike its ortholog from Sulfolobus tokodaii, CinF does not exhibit FBP phosphatase activity. Instead, it functions as a protein phosphatase that specifically dephosphorylates and stabilizes IκBα. The IκBα phosphatase activity is essential for the role of CinF in C. burnetii virulence. Our results establish that C. burnetii utilizes a protein adapted from sugar metabolism to subvert host immunity." @default.
- W4200493036 created "2021-12-31" @default.
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- W4200493036 date "2021-12-20" @default.
- W4200493036 modified "2023-10-11" @default.
- W4200493036 title "<i>Coxiella burnetii</i> inhibits host immunity by a protein phosphatase adapted from glycolysis" @default.
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- W4200493036 doi "https://doi.org/10.1073/pnas.2110877119" @default.
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