FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200494065> ?p ?o ?g. }

• W4200494065 abstract "Primordial germ cells (PGCs) are undifferentiated gametes with heterogeneity, an evolutionarily conserved characteristic across various organisms. Although dynamic selection at the level of early germ cell populations is an important biological feature linked to fertility, the heterogeneity of PGCs in avian species has not been characterized. In this study, we sought to evaluate PGC heterogeneity in zebra finch using a single-cell RNA sequencing (scRNA-seq) approach. Using scRNA-seq of embryonic gonadal cells from male and female zebra finches at Hamburger and Hamilton (HH) stage 28, we annotated nine cell types from 20 cell clusters. We found that PGCs previously considered a single population can be separated into three subtypes showing differences in apoptosis, proliferation, and other biological processes. The three PGC subtypes were specifically enriched for genes showing expression patterns related to germness or pluripotency, suggesting functional differences in PGCs according to the three subtypes. Additionally, we discovered a novel biomarker, SMC1B, for gonadal PGCs in zebra finch. The results provide the first evidence of substantial heterogeneity in PGCs previously considered a single population in birds. This discovery expands our understanding of PGCs to avian species, and provides a basis for further research." @default.
• W4200494065 created "2021-12-31" @default.
• W4200494065 creator A5047636711 @default.
• W4200494065 creator A5059304389 @default.
• W4200494065 creator A5074382424 @default.
• W4200494065 creator A5085409145 @default.
• W4200494065 creator A5091422877 @default.
• W4200494065 date "2021-12-09" @default.
• W4200494065 modified "2023-10-17" @default.
• W4200494065 title "Single-Cell RNA Sequencing Revealed the Heterogeneity of Gonadal Primordial Germ Cells in Zebra Finch (Taeniopygia guttata)" @default.
• W4200494065 cites W1847753680 @default.
• W4200494065 cites W1966758700 @default.
• W4200494065 cites W1968471467 @default.
• W4200494065 cites W1979426829 @default.
• W4200494065 cites W1983538883 @default.
• W4200494065 cites W1991890731 @default.
• W4200494065 cites W2015242108 @default.
• W4200494065 cites W2015284522 @default.
• W4200494065 cites W2024006846 @default.
• W4200494065 cites W2031502846 @default.
• W4200494065 cites W2032285280 @default.
• W4200494065 cites W2043396979 @default.
• W4200494065 cites W2044283072 @default.
• W4200494065 cites W2050793594 @default.
• W4200494065 cites W2060868229 @default.
• W4200494065 cites W2062853358 @default.
• W4200494065 cites W2084214967 @default.
• W4200494065 cites W2094892383 @default.
• W4200494065 cites W2110065044 @default.
• W4200494065 cites W2130614519 @default.
• W4200494065 cites W2140034535 @default.
• W4200494065 cites W2150014745 @default.
• W4200494065 cites W2160710558 @default.
• W4200494065 cites W2168502079 @default.
• W4200494065 cites W2238949050 @default.
• W4200494065 cites W2433553652 @default.
• W4200494065 cites W2463736608 @default.
• W4200494065 cites W2746479894 @default.
• W4200494065 cites W2782393234 @default.
• W4200494065 cites W2804747675 @default.
• W4200494065 cites W2884236132 @default.
• W4200494065 cites W2909269743 @default.
• W4200494065 cites W2929195263 @default.
• W4200494065 cites W2936052783 @default.
• W4200494065 cites W2945484030 @default.
• W4200494065 cites W2952630931 @default.
• W4200494065 cites W2953152325 @default.
• W4200494065 cites W2980081995 @default.
• W4200494065 cites W2991012148 @default.
• W4200494065 cites W3004127014 @default.
• W4200494065 cites W3015111697 @default.
• W4200494065 cites W3016430281 @default.
• W4200494065 cites W3021021855 @default.
• W4200494065 cites W3045396803 @default.
• W4200494065 cites W3125298061 @default.
• W4200494065 cites W3134675058 @default.
• W4200494065 cites W3136173882 @default.
• W4200494065 doi "https://doi.org/10.3389/fcell.2021.791335" @default.
• W4200494065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34957119" @default.
• W4200494065 hasPublicationYear "2021" @default.
• W4200494065 type Work @default.
• W4200494065 citedByCount "5" @default.
• W4200494065 countsByYear W42004940652022 @default.
• W4200494065 countsByYear W42004940652023 @default.
• W4200494065 crossrefType "journal-article" @default.
• W4200494065 hasAuthorship W4200494065A5047636711 @default.
• W4200494065 hasAuthorship W4200494065A5059304389 @default.
• W4200494065 hasAuthorship W4200494065A5074382424 @default.
• W4200494065 hasAuthorship W4200494065A5085409145 @default.
• W4200494065 hasAuthorship W4200494065A5091422877 @default.
• W4200494065 hasBestOaLocation W42004940651 @default.
• W4200494065 hasConcept C104317684 @default.
• W4200494065 hasConcept C144024400 @default.
• W4200494065 hasConcept C145103041 @default.
• W4200494065 hasConcept C149923435 @default.
• W4200494065 hasConcept C169760540 @default.
• W4200494065 hasConcept C196843134 @default.
• W4200494065 hasConcept C2778917935 @default.
• W4200494065 hasConcept C2779122487 @default.
• W4200494065 hasConcept C2908647359 @default.
• W4200494065 hasConcept C2992280869 @default.
• W4200494065 hasConcept C54355233 @default.
• W4200494065 hasConcept C86803240 @default.
• W4200494065 hasConceptScore W4200494065C104317684 @default.
• W4200494065 hasConceptScore W4200494065C144024400 @default.
• W4200494065 hasConceptScore W4200494065C145103041 @default.
• W4200494065 hasConceptScore W4200494065C149923435 @default.
• W4200494065 hasConceptScore W4200494065C169760540 @default.
• W4200494065 hasConceptScore W4200494065C196843134 @default.
• W4200494065 hasConceptScore W4200494065C2778917935 @default.
• W4200494065 hasConceptScore W4200494065C2779122487 @default.
• W4200494065 hasConceptScore W4200494065C2908647359 @default.
• W4200494065 hasConceptScore W4200494065C2992280869 @default.
• W4200494065 hasConceptScore W4200494065C54355233 @default.
• W4200494065 hasConceptScore W4200494065C86803240 @default.
• W4200494065 hasLocation W42004940651 @default.
• W4200494065 hasLocation W42004940652 @default.
• W4200494065 hasLocation W42004940653 @default.
• W4200494065 hasLocation W42004940654 @default.
• W4200494065 hasOpenAccess W4200494065 @default.

• next