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- W4200496989 endingPage "1916" @default.
- W4200496989 startingPage "1916" @default.
- W4200496989 abstract "Although strong connections exist between the carcinogenesis of gastric cancer and chronic inflammation, gastric cancer is unique in that the chronic gastritis which frequently precedes carcinogenesis is strongly associated with H. pylori infection. The interplay between H. pylori virulence factors and host immune cells is complex but culminates in the activation of inflammatory pathways and transcription factors such as NF-κB, STAT3, and AP-1, all of which upregulate cytokine production. Due to the key role of cytokines in modulating the immune response against tumour cells as well as possibly stimulating tumour growth and proliferation, different patterns of cytokine secretion may be associated with varying patient outcomes. In relation to gastric cancer, interleukin-6, 8, 10, 17A, TNF, and IFN-γ may have pro-tumour properties, although interleukin-10, TNF, and IFN-γ may have anti-tumour effects. However, due to the lack of studies investigating patient outcomes, only a link between higher interleukin-6 levels and poorer prognosis has been demonstrated. Further investigations which link peripheral cytokine levels to patient prognosis may elucidate important pathological mechanisms in gastric cancer which adversely impact patient survival and allow treatments targeting these processes to be developed." @default.
- W4200496989 created "2021-12-31" @default.
- W4200496989 creator A5025720772 @default.
- W4200496989 creator A5056733821 @default.
- W4200496989 creator A5071226647 @default.
- W4200496989 creator A5077730283 @default.
- W4200496989 date "2021-12-14" @default.
- W4200496989 modified "2023-09-26" @default.
- W4200496989 title "Peripheral Cytokine Levels as a Prognostic Indicator in Gastric Cancer: A Review of Existing Literature" @default.
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