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• W4200499173 endingPage "103026" @default.
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• W4200499173 abstract "In the present study, the tannic acid-modified magnetic hydrotalcite-based MgAl nanoparticles ([email protected]@Fe3O4 NPs) were synthesized and assessed as a novel magnetic-targeted drug delivery system to the estrogen receptor (ER)-expressing colorectal cancer cells in vitro. In addition, FT-IR, EDS, DLS, and XRD measurements were employed for confirming the successful loading of doxorubicin (DOX), a widely-used chemotherapeutic agent, on the [email protected]@Fe3O4 NPs. The NPs exhibited a negative zeta potential value due to the presence of negatively charged molecules on their surface. The lading of DOX on the [email protected]@Fe3O4 NPs resulted in reducing their negative charge. TEM and FESEM images exhibited a layered HT structure with irregular edges and a mean size of 70 nm Fe3O4 NPs were visualized as small quasi-spherical particles with a uniform size of 12 nm. The [email protected]@Fe3O4 NPs had higher solubility at acidic pH than that at pH 7.4. Further, the entrapment efficiency of DOX in the [email protected]@Fe3O4 NPs was obtained about 51% at pH 7.4. The in vitro release of the DOX/[email protected]@Fe3O4 NPs indicated a pH-dependent biphasic and sustained release of DOX as an initial rapid release in the first 24 h, followed by a 120-h sustained release. Furthermore, the safety and biocompatibility of the [email protected]@Fe3O4 NPs were confirmed through using hemolysis and MTT assays. Based on the results of fluorescence microscopy and flow cytometry, a higher DOX cellular uptake was observed in the ER-positive HCT116 and LoVo cells treated with the DOX/[email protected]@Fe3O4 NPs compared to the ER-negative HEK293 ones. Treatment with the DOX/[email protected]@Fe3O4 NPs led to more cytotoxicity than free DOX did and enhanced the DOX-induced reactive oxygen species (ROS) generation and subsequent apoptosis in colorectal cancer cells. Finally, applying a 0.6 T static magnetic field resulted in improving the anti-proliferative activity of the DOX/[email protected]@Fe3O4 NPs in HCT116 cells in a time exposure-dependent manner and enhancing ROS production. In general, the prepared NPs can serve as a promising candidate for the pH-responsive and magnetic-targeted delivery to the ER-expressing cells." @default.
• W4200499173 created "2021-12-31" @default.
• W4200499173 creator A5006853048 @default.
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• W4200499173 date "2022-02-01" @default.
• W4200499173 modified "2023-10-07" @default.
• W4200499173 title "Tannic acid-modified magnetic hydrotalcite-based MgAl nanoparticles for the in vitro targeted delivery of doxorubicin to the estrogen receptor-overexpressing colorectal cancer cells" @default.
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• W4200499173 doi "https://doi.org/10.1016/j.jddst.2021.103026" @default.
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