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- W4200500971 abstract "Treatment of hypertension-mediated cardiac damage with left ventricular (LV) hypertrophy (LVH) and heart failure remains challenging. To identify novel targets, we performed comparative transcriptome analysis between genetic models derived from stroke-prone spontaneously hypertensive rats (SHRSP). Here, we identified carboxypeptidase X 2 (Cpxm2) as a genetic locus affecting LV mass. Analysis of isolated rat cardiomyocytes and cardiofibroblasts indicated Cpxm2 expression and intrinsic upregulation in genetic hypertension. Immunostaining indicated that CPXM2 associates with the t-tubule network of cardiomyocytes. The functional role of Cpxm2 was further investigated in Cpxm2-deficient (KO) and wild-type (WT) mice exposed to deoxycorticosterone acetate (DOCA). WT and KO animals developed severe and similar systolic hypertension in response to DOCA. WT mice developed severe LV damage, including increases in LV masses and diameters, impairment of LV systolic and diastolic function and reduced ejection fraction. These changes were significantly ameliorated or even normalized (i.e., ejection fraction) in KO-DOCA animals. LV transcriptome analysis showed a molecular cardiac hypertrophy/remodeling signature in WT but not KO mice with significant upregulation of 1234 transcripts, including Cpxm2, in response to DOCA. Analysis of endomyocardial biopsies from patients with cardiac hypertrophy indicated significant upregulation of CPXM2 expression. These data support further translational investigation of CPXM2." @default.
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- W4200500971 date "2021-12-16" @default.
- W4200500971 modified "2023-10-10" @default.
- W4200500971 title "Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension" @default.
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- W4200500971 cites W1966736466 @default.
- W4200500971 cites W1975421091 @default.
- W4200500971 cites W1983857788 @default.
- W4200500971 cites W2000299239 @default.
- W4200500971 cites W2008074040 @default.
- W4200500971 cites W2008485307 @default.
- W4200500971 cites W2009745446 @default.
- W4200500971 cites W2019721104 @default.
- W4200500971 cites W2021257277 @default.
- W4200500971 cites W2036889956 @default.
- W4200500971 cites W2041981225 @default.
- W4200500971 cites W2046974910 @default.
- W4200500971 cites W2052780003 @default.
- W4200500971 cites W2054947184 @default.
- W4200500971 cites W2066385204 @default.
- W4200500971 cites W2074844506 @default.
- W4200500971 cites W2089759938 @default.
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- W4200500971 cites W2136378096 @default.
- W4200500971 cites W2146512944 @default.
- W4200500971 cites W2153358095 @default.
- W4200500971 cites W2157998551 @default.
- W4200500971 cites W2158217645 @default.
- W4200500971 cites W2164944864 @default.
- W4200500971 cites W2165621526 @default.
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- W4200500971 cites W22927035 @default.
- W4200500971 cites W2307048283 @default.
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- W4200500971 cites W2461564820 @default.
- W4200500971 cites W2461646772 @default.
- W4200500971 cites W2461837903 @default.
- W4200500971 cites W2516797805 @default.
- W4200500971 cites W2581745547 @default.
- W4200500971 cites W2598403127 @default.
- W4200500971 cites W2746580249 @default.
- W4200500971 cites W2770837559 @default.
- W4200500971 cites W2803741566 @default.
- W4200500971 cites W2806524607 @default.
- W4200500971 cites W2807302479 @default.
- W4200500971 cites W2884555778 @default.
- W4200500971 cites W2890631785 @default.
- W4200500971 cites W2890858012 @default.
- W4200500971 cites W2894724600 @default.
- W4200500971 cites W2908569218 @default.
- W4200500971 cites W2913263558 @default.
- W4200500971 cites W2914487332 @default.
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- W4200500971 cites W2921336580 @default.
- W4200500971 cites W2944837282 @default.
- W4200500971 cites W2945334580 @default.
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- W4200500971 doi "https://doi.org/10.1038/s41440-021-00826-8" @default.
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