Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200501674> ?p ?o ?g. }
- W4200501674 endingPage "13560" @default.
- W4200501674 startingPage "13560" @default.
- W4200501674 abstract "Membranous nephropathy (MN) is an important cause of nephrotic syndrome and chronic kidney disease (CKD) in adults. The pathogenic significance of B cells in MN is increasingly recognized, especially following the discovery of various autoantibodies that target specific podocytic antigens and the promising treatment responses seen with B cell depleting therapies. The presence of autoreactive B cells and autoantibodies that bind to antigens on podocyte surfaces are characteristic features of MN, and are the result of breaches in central and peripheral tolerance of B lymphocytes. These perturbations in B cell tolerance include altered B lymphocyte subsets, dysregulation of genes that govern immunoglobulin production, aberrant somatic hypermutation and co-stimulatory signalling, abnormal expression of B cell-related cytokines, and increased B cell infiltrates and organized tertiary lymphoid structures within the kidneys. An understanding of the role of B cell tolerance and homeostasis may have important implications for patient management in MN, as conventional immunosuppressive treatments and novel B cell-targeted therapies show distinct effects on proliferation, differentiation and reconstitution in different B cell subsets. Circulating B lymphocytes and related cytokines may serve as potential biomarkers for treatment selection, monitoring of therapeutic response and prediction of disease relapse. These recent advances in the understanding of B cell tolerance in MN have provided greater insight into its immunopathogenesis and potential novel strategies for disease monitoring and treatment." @default.
- W4200501674 created "2021-12-31" @default.
- W4200501674 creator A5039752296 @default.
- W4200501674 creator A5041775683 @default.
- W4200501674 creator A5065649607 @default.
- W4200501674 date "2021-12-17" @default.
- W4200501674 modified "2023-10-16" @default.
- W4200501674 title "B Cells in Primary Membranous Nephropathy: Escape from Immune Tolerance and Implications for Patient Management" @default.
- W4200501674 cites W1508120038 @default.
- W4200501674 cites W1516874144 @default.
- W4200501674 cites W1528700368 @default.
- W4200501674 cites W1538595011 @default.
- W4200501674 cites W1543903698 @default.
- W4200501674 cites W1551513387 @default.
- W4200501674 cites W1565220551 @default.
- W4200501674 cites W1576993812 @default.
- W4200501674 cites W1585544003 @default.
- W4200501674 cites W1600867898 @default.
- W4200501674 cites W1642392901 @default.
- W4200501674 cites W1696920490 @default.
- W4200501674 cites W1914343637 @default.
- W4200501674 cites W1964895771 @default.
- W4200501674 cites W1966460557 @default.
- W4200501674 cites W1966851529 @default.
- W4200501674 cites W1966949480 @default.
- W4200501674 cites W1972564604 @default.
- W4200501674 cites W1974709994 @default.
- W4200501674 cites W1978440559 @default.
- W4200501674 cites W1982924102 @default.
- W4200501674 cites W1986167294 @default.
- W4200501674 cites W1990393650 @default.
- W4200501674 cites W1993730263 @default.
- W4200501674 cites W2001562013 @default.
- W4200501674 cites W2004899866 @default.
- W4200501674 cites W2005862926 @default.
- W4200501674 cites W2005985173 @default.
- W4200501674 cites W2008977168 @default.
- W4200501674 cites W2009501393 @default.
- W4200501674 cites W2016208323 @default.
- W4200501674 cites W2016475082 @default.
- W4200501674 cites W2018459774 @default.
- W4200501674 cites W2019177796 @default.
- W4200501674 cites W2021096251 @default.
- W4200501674 cites W2026303060 @default.
- W4200501674 cites W2027135059 @default.
- W4200501674 cites W2030472916 @default.
- W4200501674 cites W2033023902 @default.
- W4200501674 cites W2034360108 @default.
- W4200501674 cites W2034585575 @default.
- W4200501674 cites W2038328728 @default.
- W4200501674 cites W2038390766 @default.
- W4200501674 cites W2040884296 @default.
- W4200501674 cites W2045555134 @default.
- W4200501674 cites W2047225646 @default.
- W4200501674 cites W2047553972 @default.
- W4200501674 cites W2050564543 @default.
- W4200501674 cites W2052438035 @default.
- W4200501674 cites W2058170201 @default.
- W4200501674 cites W2067632847 @default.
- W4200501674 cites W2069282346 @default.
- W4200501674 cites W2072320300 @default.
- W4200501674 cites W2076104117 @default.
- W4200501674 cites W2076198413 @default.
- W4200501674 cites W2077286174 @default.
- W4200501674 cites W2080515517 @default.
- W4200501674 cites W2081064697 @default.
- W4200501674 cites W2083760961 @default.
- W4200501674 cites W2086080135 @default.
- W4200501674 cites W2088328410 @default.
- W4200501674 cites W2089916413 @default.
- W4200501674 cites W2097302710 @default.
- W4200501674 cites W2098497060 @default.
- W4200501674 cites W2099390796 @default.
- W4200501674 cites W2100213817 @default.
- W4200501674 cites W2102771576 @default.
- W4200501674 cites W2104769463 @default.
- W4200501674 cites W2122581834 @default.
- W4200501674 cites W2124211877 @default.
- W4200501674 cites W2126790357 @default.
- W4200501674 cites W2127127482 @default.
- W4200501674 cites W2133344401 @default.
- W4200501674 cites W2133527269 @default.
- W4200501674 cites W2134544592 @default.
- W4200501674 cites W2137896826 @default.
- W4200501674 cites W2141812411 @default.
- W4200501674 cites W2157296439 @default.
- W4200501674 cites W2157717187 @default.
- W4200501674 cites W2158381180 @default.
- W4200501674 cites W2161537704 @default.
- W4200501674 cites W2161754737 @default.
- W4200501674 cites W2162337442 @default.
- W4200501674 cites W2165608602 @default.
- W4200501674 cites W2166822765 @default.
- W4200501674 cites W2168217071 @default.
- W4200501674 cites W2171113939 @default.
- W4200501674 cites W2211752697 @default.
- W4200501674 cites W2216117723 @default.
- W4200501674 cites W2264971900 @default.