FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200501776> ?p ?o ?g. }

• W4200501776 abstract "Abdominal aortic aneurysm (AAA) is a common degenerative cardiovascular disease whose pathobiology is not clearly understood. The cellular heterogeneity and cell-type-specific gene regulation of vascular cells in human AAA have not been well-characterized. Here, we performed analysis of whole-genome sequencing data in AAA patients versus controls with the aim of detecting disease-associated variants that may affect gene regulation in human aortic smooth muscle cells (AoSMC) and human aortic endothelial cells (HAEC), two cell types of high relevance to AAA disease. To support this analysis, we generated H3K27ac HiChIP data for these cell types and inferred cell-type-specific gene regulatory networks. We observed that AAA-associated variants were most enriched in regulatory regions in AoSMC, compared with HAEC and CD4+ cells. The cell-type-specific regulation defined by this HiChIP data supported the importance of ERG and the KLF family of transcription factors in AAA disease. The analysis of regulatory elements that contain noncoding variants and also are differentially open between AAA patients and controls revealed the significance of the interleukin-6-mediated signaling pathway. This finding was further validated by including information from the deleteriousness effect of nonsynonymous single-nucleotide variants in AAA patients and additional control data from the Medical Genome Reference Bank dataset. These results shed important insights into AAA pathogenesis and provide a model for cell-type-specific analysis of disease-associated variants." @default.
• W4200501776 created "2021-12-31" @default.
• W4200501776 creator A5008171524 @default.
• W4200501776 creator A5015401462 @default.
• W4200501776 creator A5035361085 @default.
• W4200501776 creator A5058198453 @default.
• W4200501776 creator A5065819218 @default.
• W4200501776 date "2021-12-20" @default.
• W4200501776 modified "2023-09-28" @default.
• W4200501776 title "Leveraging cell-type-specific regulatory networks to interpret genetic variants in abdominal aortic aneurysm" @default.
• W4200501776 cites W1605145036 @default.
• W4200501776 cites W1732757562 @default.
• W4200501776 cites W1900984040 @default.
• W4200501776 cites W1919473389 @default.
• W4200501776 cites W1975311766 @default.
• W4200501776 cites W1984662275 @default.
• W4200501776 cites W2014677321 @default.
• W4200501776 cites W2040738170 @default.
• W4200501776 cites W2054702433 @default.
• W4200501776 cites W2078644058 @default.
• W4200501776 cites W2079975216 @default.
• W4200501776 cites W2084160423 @default.
• W4200501776 cites W2099085143 @default.
• W4200501776 cites W2100867326 @default.
• W4200501776 cites W2124649657 @default.
• W4200501776 cites W2129952088 @default.
• W4200501776 cites W2166004158 @default.
• W4200501776 cites W2185693210 @default.
• W4200501776 cites W2259938310 @default.
• W4200501776 cites W2295275561 @default.
• W4200501776 cites W2339719595 @default.
• W4200501776 cites W2467359821 @default.
• W4200501776 cites W2523285811 @default.
• W4200501776 cites W2535426958 @default.
• W4200501776 cites W2554555398 @default.
• W4200501776 cites W2557527880 @default.
• W4200501776 cites W2576745741 @default.
• W4200501776 cites W2580166653 @default.
• W4200501776 cites W2584394140 @default.
• W4200501776 cites W2612554572 @default.
• W4200501776 cites W2621109613 @default.
• W4200501776 cites W2789833802 @default.
• W4200501776 cites W2884651274 @default.
• W4200501776 cites W2889960200 @default.
• W4200501776 cites W2897314609 @default.
• W4200501776 cites W2923327939 @default.
• W4200501776 cites W2942073938 @default.
• W4200501776 cites W2952947531 @default.
• W4200501776 cites W2953072478 @default.
• W4200501776 cites W2973702082 @default.
• W4200501776 cites W2973992289 @default.
• W4200501776 cites W3002728042 @default.
• W4200501776 cites W3063428689 @default.
• W4200501776 cites W3088087046 @default.
• W4200501776 cites W3092353457 @default.
• W4200501776 cites W3151923718 @default.
• W4200501776 cites W3163316878 @default.
• W4200501776 cites W4210984075 @default.
• W4200501776 doi "https://doi.org/10.1073/pnas.2115601119" @default.
• W4200501776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34930827" @default.
• W4200501776 hasPublicationYear "2021" @default.
• W4200501776 type Work @default.
• W4200501776 citedByCount "6" @default.
• W4200501776 countsByYear W42005017762022 @default.
• W4200501776 countsByYear W42005017762023 @default.
• W4200501776 crossrefType "journal-article" @default.
• W4200501776 hasAuthorship W4200501776A5008171524 @default.
• W4200501776 hasAuthorship W4200501776A5015401462 @default.
• W4200501776 hasAuthorship W4200501776A5035361085 @default.
• W4200501776 hasAuthorship W4200501776A5058198453 @default.
• W4200501776 hasAuthorship W4200501776A5065819218 @default.
• W4200501776 hasBestOaLocation W42005017761 @default.
• W4200501776 hasConcept C104317684 @default.
• W4200501776 hasConcept C141071460 @default.
• W4200501776 hasConcept C142724271 @default.
• W4200501776 hasConcept C1491633281 @default.
• W4200501776 hasConcept C150194340 @default.
• W4200501776 hasConcept C189014844 @default.
• W4200501776 hasConcept C2776098176 @default.
• W4200501776 hasConcept C2779134260 @default.
• W4200501776 hasConcept C2779993416 @default.
• W4200501776 hasConcept C54355233 @default.
• W4200501776 hasConcept C67339327 @default.
• W4200501776 hasConcept C70721500 @default.
• W4200501776 hasConcept C71924100 @default.
• W4200501776 hasConcept C86803240 @default.
• W4200501776 hasConceptScore W4200501776C104317684 @default.
• W4200501776 hasConceptScore W4200501776C141071460 @default.
• W4200501776 hasConceptScore W4200501776C142724271 @default.
• W4200501776 hasConceptScore W4200501776C1491633281 @default.
• W4200501776 hasConceptScore W4200501776C150194340 @default.
• W4200501776 hasConceptScore W4200501776C189014844 @default.
• W4200501776 hasConceptScore W4200501776C2776098176 @default.
• W4200501776 hasConceptScore W4200501776C2779134260 @default.
• W4200501776 hasConceptScore W4200501776C2779993416 @default.
• W4200501776 hasConceptScore W4200501776C54355233 @default.
• W4200501776 hasConceptScore W4200501776C67339327 @default.
• W4200501776 hasConceptScore W4200501776C70721500 @default.
• W4200501776 hasConceptScore W4200501776C71924100 @default.
• W4200501776 hasConceptScore W4200501776C86803240 @default.

• next