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- W4200503002 abstract "Neoantigens are tumor-specific proteins and peptides that can be highly immunogenic. Immune-mediated tumor rejection is strongly associated with cytotoxic responses to neoantigen-derived peptides in noncovalent association with self-HLA molecules. Neoantigen-based therapies, such as adoptive T cell transfer, have shown the potential to induce remission of treatment-resistant metastatic disease in select patients. Cancer vaccines are similarly designed to elicit or amplify antigen-specific T cell populations and stimulate directed antitumor immunity, but the selection and prioritization of the neoantigens remains a challenge. Bioinformatic algorithms can predict tumor neoantigens from somatic mutations, insertion-deletions, and other aberrant peptide products, but this often leads to hundreds of potential neoepitopes, all unique for that tumor. Selecting neoantigens for cancer vaccines is complicated by the technical challenges of neoepitope discovery, the diversity of HLA molecules, and intratumoral heterogeneity of passenger mutations leading to immune escape. Despite strong preclinical evidence, few neoantigen cancer vaccines tested in vivo have generated epitope-specific T cell populations, suggesting suboptimal immune system activation. In this chapter, we review factors affecting the prioritization and delivery of candidate neoantigens in the design of therapeutic and preventive cancer vaccines and consider synergism with standard chemotherapies." @default.
- W4200503002 created "2021-12-31" @default.
- W4200503002 creator A5033246326 @default.
- W4200503002 creator A5047921909 @default.
- W4200503002 date "2021-12-17" @default.
- W4200503002 modified "2023-09-26" @default.
- W4200503002 title "Beyond Sequencing: Prioritizing and Delivering Neoantigens for Cancer Vaccines" @default.
- W4200503002 cites W1519576779 @default.
- W4200503002 cites W1580205301 @default.
- W4200503002 cites W1688526230 @default.
- W4200503002 cites W1990338386 @default.
- W4200503002 cites W1994993231 @default.
- W4200503002 cites W2002623789 @default.
- W4200503002 cites W2006759360 @default.
- W4200503002 cites W2007026865 @default.
- W4200503002 cites W2011076638 @default.
- W4200503002 cites W2011458181 @default.
- W4200503002 cites W2021472146 @default.
- W4200503002 cites W2039551908 @default.
- W4200503002 cites W2049553585 @default.
- W4200503002 cites W2050407789 @default.
- W4200503002 cites W2076096828 @default.
- W4200503002 cites W2076956606 @default.
- W4200503002 cites W2079315541 @default.
- W4200503002 cites W2079696222 @default.
- W4200503002 cites W2104885590 @default.
- W4200503002 cites W2108371618 @default.
- W4200503002 cites W2112752664 @default.
- W4200503002 cites W2113000254 @default.
- W4200503002 cites W2120183880 @default.
- W4200503002 cites W2125258954 @default.
- W4200503002 cites W2131989349 @default.
- W4200503002 cites W2137158234 @default.
- W4200503002 cites W2140235037 @default.
- W4200503002 cites W2145932544 @default.
- W4200503002 cites W2149848966 @default.
- W4200503002 cites W2154974159 @default.
- W4200503002 cites W2156748975 @default.
- W4200503002 cites W2159059319 @default.
- W4200503002 cites W2166810745 @default.
- W4200503002 cites W2204416339 @default.
- W4200503002 cites W2210453860 @default.
- W4200503002 cites W2214699570 @default.
- W4200503002 cites W2239878160 @default.
- W4200503002 cites W2270152626 @default.
- W4200503002 cites W2291298003 @default.
- W4200503002 cites W2340563390 @default.
- W4200503002 cites W2345765068 @default.
- W4200503002 cites W2404396229 @default.
- W4200503002 cites W2412158473 @default.
- W4200503002 cites W2412171122 @default.
- W4200503002 cites W2521176812 @default.
- W4200503002 cites W2521503673 @default.
- W4200503002 cites W2531246324 @default.
- W4200503002 cites W2534772180 @default.
- W4200503002 cites W2536906012 @default.
- W4200503002 cites W2558035065 @default.
- W4200503002 cites W2559953355 @default.
- W4200503002 cites W2560367415 @default.
- W4200503002 cites W2560839368 @default.
- W4200503002 cites W2561499686 @default.
- W4200503002 cites W2564809671 @default.
- W4200503002 cites W2578528809 @default.
- W4200503002 cites W2586368282 @default.
- W4200503002 cites W2586629973 @default.
- W4200503002 cites W2587048937 @default.
- W4200503002 cites W2587111948 @default.
- W4200503002 cites W2587486634 @default.
- W4200503002 cites W2588307902 @default.
- W4200503002 cites W2589139221 @default.
- W4200503002 cites W2590497374 @default.
- W4200503002 cites W2594226172 @default.
- W4200503002 cites W2599766179 @default.
- W4200503002 cites W2611086965 @default.
- W4200503002 cites W2612650744 @default.
- W4200503002 cites W2616983963 @default.
- W4200503002 cites W2630192492 @default.
- W4200503002 cites W2724264513 @default.
- W4200503002 cites W2725858612 @default.
- W4200503002 cites W2728365508 @default.
- W4200503002 cites W2729722235 @default.
- W4200503002 cites W2750497670 @default.
- W4200503002 cites W2752085764 @default.
- W4200503002 cites W2754562068 @default.
- W4200503002 cites W2766209631 @default.
- W4200503002 cites W2767699537 @default.
- W4200503002 cites W2769390339 @default.
- W4200503002 cites W2769985437 @default.
- W4200503002 cites W2771148323 @default.
- W4200503002 cites W2773406691 @default.
- W4200503002 cites W2774113098 @default.
- W4200503002 cites W2774585454 @default.
- W4200503002 cites W2774712455 @default.
- W4200503002 cites W2779337961 @default.
- W4200503002 cites W2782708334 @default.
- W4200503002 cites W2786003901 @default.
- W4200503002 cites W2789167832 @default.
- W4200503002 cites W2791512052 @default.