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• W4200504014 abstract "Tangshen formula (TSF) is a traditional Chinese medicine composed of seven medicinal herbs including Astragalus membranaceus, Rehmannia glutinosa Libosch, Citrus aurantium L., etc. which is used to treat diabetic nephropathy III, IV qi and yin deficiency and stasis syndrome. Most of the studies on TSF are pharmacological and pharmacodynamic experiments. There are few basic studies on its chemical substances, and the effective constituents are not clear.To analyse the main chemical components of TSF and the absorbed components in rat plasma following oral administration based on liquid chromatography tandem mass spectrometry (LC-MS/MS). Moreover, providing a rapid and valid analytical strategy for simultaneous determination of six components in rat plasma and use it in pharmacokinetic studies.A total of 132 components were identified in TSF, and 44 components were identified in rat plasma after oral TSF, 35 of which were prototype components and nine were metabolic components. A sensitive and reliable LC-MS/MS method was developed for simultaneous determination of six components in rat plasma. The intra-day and inter-day precision relative standard deviation (RSD) was lower than 15%; the accuracy of low, medium and high concentrations ranged from 80% to 120%. The recovery met the requirements and the RSD of the recoveries was less than 15%.A total of 132 components were identified in TSF. The LC-MS/MS quantitative method for the simultaneous determination of morroniside, loganin, notoginsenoside R1 , ginsenoside Re, ginsenoside Rb1 and astragaloside IV in rat plasma was established for the first time. The pharmacokinetic parameters are clarified, which can guide the clinical medication of TSF." @default.
• W4200504014 created "2021-12-31" @default.
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• W4200504014 date "2021-12-14" @default.
• W4200504014 modified "2023-10-16" @default.
• W4200504014 title "UPLC–MS/MS method for the determination of the herb composition of Tangshen formula and the <i>in vivo</i> pharmacokinetics of its metabolites in rat plasma" @default.
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• W4200504014 cites W1986656652 @default.
• W4200504014 cites W1991727273 @default.
• W4200504014 cites W2029047460 @default.
• W4200504014 cites W2038877483 @default.
• W4200504014 cites W2053502622 @default.
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• W4200504014 cites W2071191475 @default.
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• W4200504014 cites W2123252205 @default.
• W4200504014 cites W2125759498 @default.
• W4200504014 cites W2151419412 @default.
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• W4200504014 cites W2200861441 @default.
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• W4200504014 cites W2791373185 @default.
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• W4200504014 doi "https://doi.org/10.1002/pca.3098" @default.
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