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- W4200505320 endingPage "365" @default.
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- W4200505320 abstract "Tumor-associated neutrophils appear to be a crucial element of the tumor microenvironment that actively participates in the development and progression of cancerous diseases. The increased lifespan, plasticity in changing of phenotype, and functions of neutrophils influence the course of the disease and may significantly affect survival. In patients with chronic lymphocytic leukemia (CLL), disturbances in neutrophils functions impede the effective immune defense against pathogens. Therefore, understanding the mechanism underlying such a phenomenon in CLL seems to be of great importance. Here we discuss the recent reports analyzing the phenotype and functions of neutrophils in CLL, the most common leukemia in adults. We summarize the data concerning both the phenotype and the mechanisms by which neutrophils directly support the proliferation and survival of malignant B cells." @default.
- W4200505320 created "2021-12-31" @default.
- W4200505320 creator A5005291173 @default.
- W4200505320 creator A5070670456 @default.
- W4200505320 creator A5091565086 @default.
- W4200505320 date "2021-12-29" @default.
- W4200505320 modified "2023-10-10" @default.
- W4200505320 title "The Role of Neutrophils in the Pathogenesis of Chronic Lymphocytic Leukemia" @default.
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- W4200505320 doi "https://doi.org/10.3390/ijms23010365" @default.
- W4200505320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35008790" @default.
- W4200505320 hasPublicationYear "2021" @default.
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