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- W4200506341 abstract "Abstract Background: Heterogeneity exists in the relationship of remnant cholesterol (RC) with cardiovascular disease. In this study, we examined the association between RC and ischemic cardiovascular disease (ICVD) risks and the RC-related risk beyond low-density lipoprotein cholesterol (LDL-C) among people in northern China. Methods: We determined the lipid profile among 65,236 people aged 35–75 years, enrolled between 2015 and 2017, who lived in Inner Mongolia for more than 6 months. Adjusted logistic regression models were used to assess the associations between RC concentration and ICVD risks. Results: In total, 2350 ICVD events were included in the study. RC was significantly associated with the risk of ICVD, CHD events, and ischemic stroke (IS) (ICVD odds ratio [OR] fourth quartile vs first quartile( Q4 vs Q1) 1.253, 95% confidence interval [CI] 1.104–1.421, P trend <0.001; CHD events OR Q4 vs Q1 1.222, 95% CI 1.018–1.466, P trend =0.034; IS OR Q4 vs Q1 1.288, 95% CI 1.090–1.522, P trend =0.001). This association remained significant after including LDL-C and high-density lipoprotein cholesterol (HDL-C). Moreover, the discordant high RC/low LDL-C groupwas associated with increased ICVD risk compared with the low RC/low LDL-C group (OR 1.174, 95% CI 1.029–1.339). Similar results were obtained when adjusting for traditional risk factors of ICVD. Conclusions: We found that RC was associated with an increased risk of ICVD independent of traditional risk factors, LDL-C, and HDL-C levels. The interaction of RC and LDL-C was associated with the risk of ICVD risks." @default.
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- W4200506341 date "2021-12-07" @default.
- W4200506341 modified "2023-09-26" @default.
- W4200506341 title "Remnant Cholesterol and Ischemic Cardiovascular Disease: A Cross-Sectional Study in Northern China" @default.
- W4200506341 doi "https://doi.org/10.21203/rs.3.rs-1140711/v1" @default.
- W4200506341 hasPublicationYear "2021" @default.
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