Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200507911> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W4200507911 abstract "Adalimumab is an immunosuppressive drug that neutralizes the membrane and soluble form of tumor necrosis factor alpha (TNF-α). As a representative of anti-TNF-α inhibitors, it is used in the treatment of articular psoriasis, rheumatoid arthritis, and Crohn's disease. The aim of the study was to evaluate changes in the expression of genes encoding HRH1-4 receptors in human skin keratinocytes (HaCaT line) treated with bacterial lipopolysaccharide followed by adalimumab compared to the control culture. HaCaT was exposed to 1 ng / ml LPS for 8 hours and then to 8 µg / ml adalimumab for 2, 8 and 24 hours compared to the control culture. Molecular analysis included the determination of the microarray expression profile of the assessed genes, which was then validated with the quantitative real-time polymerase chain reaction preceded by reverse transcription (RTqPCR) method. Under conditions of induced inflammation -LPS, the concentration of HRH1-3 is significantly lower compared to control and increases with the addition of the drug (p <0.05). The highest concentration of HRH1 and HRH3 in keratinocyte cultures exposed to adalimumab was observed after 8 hours of incubation. HRH2 expression is also highest under the influence of adalimumab (p<0.05). We have shown that adalimumab influences the activity of the histaminergic system in skin keratinocytes in vitro. The complex nature of the histaminergic system was confirmed." @default.
- W4200507911 created "2021-12-31" @default.
- W4200507911 creator A5012979695 @default.
- W4200507911 creator A5033816741 @default.
- W4200507911 creator A5059528565 @default.
- W4200507911 creator A5088556624 @default.
- W4200507911 creator A5088917390 @default.
- W4200507911 date "2021-11-02" @default.
- W4200507911 modified "2023-09-26" @default.
- W4200507911 title "Effect of adalimumab on the expression profile of genes encoding histamine receptors in keratinocyte" @default.
- W4200507911 doi "https://doi.org/10.3390/ecmc2021-11418" @default.
- W4200507911 hasPublicationYear "2021" @default.
- W4200507911 type Work @default.
- W4200507911 citedByCount "0" @default.
- W4200507911 crossrefType "proceedings-article" @default.
- W4200507911 hasAuthorship W4200507911A5012979695 @default.
- W4200507911 hasAuthorship W4200507911A5033816741 @default.
- W4200507911 hasAuthorship W4200507911A5059528565 @default.
- W4200507911 hasAuthorship W4200507911A5088556624 @default.
- W4200507911 hasAuthorship W4200507911A5088917390 @default.
- W4200507911 hasBestOaLocation W42005079111 @default.
- W4200507911 hasConcept C1122143 @default.
- W4200507911 hasConcept C118995209 @default.
- W4200507911 hasConcept C153911025 @default.
- W4200507911 hasConcept C159545944 @default.
- W4200507911 hasConcept C170493617 @default.
- W4200507911 hasConcept C17991360 @default.
- W4200507911 hasConcept C185592680 @default.
- W4200507911 hasConcept C202751555 @default.
- W4200507911 hasConcept C203014093 @default.
- W4200507911 hasConcept C2776885963 @default.
- W4200507911 hasConcept C2777074287 @default.
- W4200507911 hasConcept C2778501154 @default.
- W4200507911 hasConcept C2778754761 @default.
- W4200507911 hasConcept C2780132546 @default.
- W4200507911 hasConcept C2780564577 @default.
- W4200507911 hasConcept C55493867 @default.
- W4200507911 hasConcept C71924100 @default.
- W4200507911 hasConcept C86803240 @default.
- W4200507911 hasConcept C98274493 @default.
- W4200507911 hasConceptScore W4200507911C1122143 @default.
- W4200507911 hasConceptScore W4200507911C118995209 @default.
- W4200507911 hasConceptScore W4200507911C153911025 @default.
- W4200507911 hasConceptScore W4200507911C159545944 @default.
- W4200507911 hasConceptScore W4200507911C170493617 @default.
- W4200507911 hasConceptScore W4200507911C17991360 @default.
- W4200507911 hasConceptScore W4200507911C185592680 @default.
- W4200507911 hasConceptScore W4200507911C202751555 @default.
- W4200507911 hasConceptScore W4200507911C203014093 @default.
- W4200507911 hasConceptScore W4200507911C2776885963 @default.
- W4200507911 hasConceptScore W4200507911C2777074287 @default.
- W4200507911 hasConceptScore W4200507911C2778501154 @default.
- W4200507911 hasConceptScore W4200507911C2778754761 @default.
- W4200507911 hasConceptScore W4200507911C2780132546 @default.
- W4200507911 hasConceptScore W4200507911C2780564577 @default.
- W4200507911 hasConceptScore W4200507911C55493867 @default.
- W4200507911 hasConceptScore W4200507911C71924100 @default.
- W4200507911 hasConceptScore W4200507911C86803240 @default.
- W4200507911 hasConceptScore W4200507911C98274493 @default.
- W4200507911 hasLocation W42005079111 @default.
- W4200507911 hasOpenAccess W4200507911 @default.
- W4200507911 hasPrimaryLocation W42005079111 @default.
- W4200507911 hasRelatedWork W1989170543 @default.
- W4200507911 hasRelatedWork W2013236714 @default.
- W4200507911 hasRelatedWork W2033021959 @default.
- W4200507911 hasRelatedWork W2123104302 @default.
- W4200507911 hasRelatedWork W2160673212 @default.
- W4200507911 hasRelatedWork W2165082357 @default.
- W4200507911 hasRelatedWork W2394511156 @default.
- W4200507911 hasRelatedWork W4200507911 @default.
- W4200507911 hasRelatedWork W4379054595 @default.
- W4200507911 hasRelatedWork W2482235299 @default.
- W4200507911 isParatext "false" @default.
- W4200507911 isRetracted "false" @default.
- W4200507911 workType "article" @default.